Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108087696> ?p ?o ?g. }
- W3108087696 endingPage "104591" @default.
- W3108087696 startingPage "104591" @default.
- W3108087696 abstract "Allergic rhinitis (AR) is tightly associated with type 2 inflammation. SFRP5 combined with WNT5A mainly inhibits chronic inflammatory response, atherosclerosis, and other metabolic disorders. However, the effect of SFRP5/WNT5A axis on recombinant human interleukin-13 (rhIL-13)-induced inflammation has not been studied. In this study, we aimed to investigate whether secreted frizzled-related protein 5 (SFRP5) could modulate the production of cytokines relevant to eosinophil infiltration and mucin secretion through blocking the activation of Wnt family 5A (WNT5A) signaling pathway. A mouse model of AR demonstrated low expression of SFRP5 and high expression of WNT5A, and indicated that the number of eosinophil and goblet cells was increased, concomitant with elevated IL-13, colony stimulating factor 2 (CSF2), chemokine ligand 11 (CCL11), Mucin 4, and Mucin 5AC levels. Furthermore, lentivirus-SFRP5 overexpression up-regulated the expression of SFRP5 but down-regulated WNT5A level, and inhibited the activation of JNK pathway via decreasing p-JNK1/2 (Thr183/Tyr185) and p-c-Jun (Ser73) protein expressions in rhIL-13-treated human nasal epithelial cells (HNEpCs). Noticeably, SFRP5 overexpression markedly reduced rhIL-13-induced inflammatory protein and mucin generation through lowered CSF2, CCL11, Mucin 4, as well as Mucin 5AC levels. Taken together, these findings confirmed the regulatory role of SFRP5/WNT5A axis in rhIL-13-mediated inflammatory response in HNEpCs." @default.
- W3108087696 created "2020-12-07" @default.
- W3108087696 creator A5032764121 @default.
- W3108087696 creator A5034654778 @default.
- W3108087696 creator A5043812611 @default.
- W3108087696 creator A5081595442 @default.
- W3108087696 creator A5084168931 @default.
- W3108087696 creator A5088539918 @default.
- W3108087696 date "2021-02-01" @default.
- W3108087696 modified "2023-10-18" @default.
- W3108087696 title "The regulatory role of SFRP5/WNT5A axis in allergic rhinitis through inhibiting JNK pathway activation and lowering mucin generation in human nasal epithelial cells" @default.
- W3108087696 cites W1540616277 @default.
- W3108087696 cites W1542023806 @default.
- W3108087696 cites W1558828517 @default.
- W3108087696 cites W1976871650 @default.
- W3108087696 cites W2002135161 @default.
- W3108087696 cites W2002280483 @default.
- W3108087696 cites W2026076920 @default.
- W3108087696 cites W2038514482 @default.
- W3108087696 cites W2045873742 @default.
- W3108087696 cites W2063885687 @default.
- W3108087696 cites W2071711382 @default.
- W3108087696 cites W2083239000 @default.
- W3108087696 cites W2089224232 @default.
- W3108087696 cites W2133010781 @default.
- W3108087696 cites W2157171881 @default.
- W3108087696 cites W2161099629 @default.
- W3108087696 cites W2171182079 @default.
- W3108087696 cites W2299931861 @default.
- W3108087696 cites W2523791674 @default.
- W3108087696 cites W2529144892 @default.
- W3108087696 cites W2593563271 @default.
- W3108087696 cites W2625761621 @default.
- W3108087696 cites W2724782993 @default.
- W3108087696 cites W2747646829 @default.
- W3108087696 cites W2793010530 @default.
- W3108087696 cites W2804522742 @default.
- W3108087696 cites W2883322907 @default.
- W3108087696 cites W2883349860 @default.
- W3108087696 cites W2888771508 @default.
- W3108087696 cites W2893169704 @default.
- W3108087696 cites W2898945841 @default.
- W3108087696 cites W2907270550 @default.
- W3108087696 cites W2923440734 @default.
- W3108087696 cites W2942005780 @default.
- W3108087696 cites W2946190857 @default.
- W3108087696 cites W2951414824 @default.
- W3108087696 cites W2956356077 @default.
- W3108087696 cites W2962796414 @default.
- W3108087696 cites W2972688956 @default.
- W3108087696 cites W2996653795 @default.
- W3108087696 cites W3002287744 @default.
- W3108087696 cites W3014808463 @default.
- W3108087696 doi "https://doi.org/10.1016/j.yexmp.2020.104591" @default.
- W3108087696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33285209" @default.
- W3108087696 hasPublicationYear "2021" @default.
- W3108087696 type Work @default.
- W3108087696 sameAs 3108087696 @default.
- W3108087696 citedByCount "8" @default.
- W3108087696 countsByYear W31080876962021 @default.
- W3108087696 countsByYear W31080876962022 @default.
- W3108087696 countsByYear W31080876962023 @default.
- W3108087696 crossrefType "journal-article" @default.
- W3108087696 hasAuthorship W3108087696A5032764121 @default.
- W3108087696 hasAuthorship W3108087696A5034654778 @default.
- W3108087696 hasAuthorship W3108087696A5043812611 @default.
- W3108087696 hasAuthorship W3108087696A5081595442 @default.
- W3108087696 hasAuthorship W3108087696A5084168931 @default.
- W3108087696 hasAuthorship W3108087696A5088539918 @default.
- W3108087696 hasConcept C101666144 @default.
- W3108087696 hasConcept C128240485 @default.
- W3108087696 hasConcept C13373296 @default.
- W3108087696 hasConcept C137620995 @default.
- W3108087696 hasConcept C164027704 @default.
- W3108087696 hasConcept C170493617 @default.
- W3108087696 hasConcept C179264091 @default.
- W3108087696 hasConcept C185592680 @default.
- W3108087696 hasConcept C203014093 @default.
- W3108087696 hasConcept C2776042228 @default.
- W3108087696 hasConcept C2776914184 @default.
- W3108087696 hasConcept C2777037409 @default.
- W3108087696 hasConcept C2780176071 @default.
- W3108087696 hasConcept C2780590879 @default.
- W3108087696 hasConcept C55493867 @default.
- W3108087696 hasConcept C62478195 @default.
- W3108087696 hasConcept C86803240 @default.
- W3108087696 hasConcept C95444343 @default.
- W3108087696 hasConceptScore W3108087696C101666144 @default.
- W3108087696 hasConceptScore W3108087696C128240485 @default.
- W3108087696 hasConceptScore W3108087696C13373296 @default.
- W3108087696 hasConceptScore W3108087696C137620995 @default.
- W3108087696 hasConceptScore W3108087696C164027704 @default.
- W3108087696 hasConceptScore W3108087696C170493617 @default.
- W3108087696 hasConceptScore W3108087696C179264091 @default.
- W3108087696 hasConceptScore W3108087696C185592680 @default.
- W3108087696 hasConceptScore W3108087696C203014093 @default.
- W3108087696 hasConceptScore W3108087696C2776042228 @default.
- W3108087696 hasConceptScore W3108087696C2776914184 @default.