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- W3108132312 abstract "Abstract Norepinephrine adjusts sensory processing in cortical networks and gates plasticity enabling adaptive behavior. The actions of norepinephrine are profoundly altered by recreational drugs like ethanol, but the consequences of these changes on distinct targets such as astrocytes, which exhibit norepinephrine-dependent Ca 2+ elevations during vigilance, are not well understood. Using in vivo two-photon imaging, we show that locomotion-induced Ca 2+ elevations in mouse astroglia are profoundly inhibited by ethanol, an effect that can be reversed by enhancing norepinephrine release. Vigilance-dependent astroglial activation is abolished by deletion of α 1A -adrenergic receptor from astroglia, indicating that norepinephrine acts directly on these ubiquitous glial cells. Ethanol reduces vigilance-dependent Ca 2+ transients in noradrenergic terminals, but has little effect on astroglial responsiveness to norepinephrine, suggesting that ethanol suppresses their activation by inhibiting norepinephrine release. Since abolition of astroglia Ca 2+ activation does not affect motor coordination, global suppression of astroglial networks may contribute to the cognitive effects of alcohol intoxication." @default.
- W3108132312 created "2020-12-07" @default.
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- W3108132312 date "2020-12-02" @default.
- W3108132312 modified "2023-10-12" @default.
- W3108132312 title "Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release" @default.
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- W3108132312 doi "https://doi.org/10.1038/s41467-020-19475-5" @default.
- W3108132312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7710743" @default.
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- W3108132312 hasPublicationYear "2020" @default.
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