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- W3108152844 abstract "The biophysical and biochemical properties of live tissues are important in the context of development and disease. Methods for evaluating these properties typically involve destroying the tissue or require specialized technology and complicated analyses. Here, we present a novel, noninvasive methodology for determining the spatial distribution of tissue features within embryos, making use of nondirectionally migrating cells and software we termed Landscape, which performs automatized high-throughput three-dimensional image registration. Using the live migrating cells as bioprobes, we identified structures within the zebrafish embryo that affect the distribution of the cells and studied one such structure constituting a physical barrier, which, in turn, influences amoeboid cell polarity. Overall, this work provides a unique approach for detecting tissue properties without interfering with animal's development. In addition, Landscape allows for integrating data from multiple samples, providing detailed and reliable quantitative evaluation of variable biological phenotypes in different organisms." @default.
- W3108152844 created "2020-12-07" @default.
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- W3108152844 date "2020-12-04" @default.
- W3108152844 modified "2023-09-23" @default.
- W3108152844 title "Using migrating cells as probes to illuminate features in live embryonic tissues" @default.
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- W3108152844 doi "https://doi.org/10.1126/sciadv.abc5546" @default.
- W3108152844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7821905" @default.
- W3108152844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33277250" @default.
- W3108152844 hasPublicationYear "2020" @default.
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