FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108210009> ?p ?o ?g. }

• W3108210009 endingPage "8" @default.
• W3108210009 startingPage "8" @default.
• W3108210009 abstract "Dietary restriction (DR) is a well-known intervention that increases lifespan and resistance to multiple forms of acute stress, including ischemia reperfusion injury. However, the effect of DR on neurological injury after cardiac arrest (CA) remains unknown.The effect of short-term DR (one week of 70% reduced daily diet) on neurological injury was investigated in rats using an asphyxial CA model. The survival curve was obtained using Kaplan-Meier survival analysis. Serum S-100β levels were detected by enzyme linked immunosorbent assay. Cellular apoptosis and neuronal damage were assessed by terminal deoxyribonucleotide transferase dUTP nick end labeling assay and Nissl staining. The oxidative stress was evaluated by immunohistochemical staining of 8-hydroxy-2'-deoxyguanosine (8-OHdG). Mitochondrial biogenesis was examined by electron microscopy and mitochondrial DNA copy number determination. The protein expression was detected by western blot. The reactive oxygen species (ROS) and metabolite levels were measured by corresponding test kits.Short-term DR significantly improved 3-day survival, neurologic deficit scores (NDS) and decreased serum S-100β levels after CA. Short-term DR also significantly attenuated cellular apoptosis, neuronal damage and oxidative stress in the brain after CA. In addition, short-term DR increased mitochondrial biogenesis as well as brain PGC-1α and SIRT1 protein expression after CA. Moreover, short-term DR increased adenosine triphosphate, β-hydroxybutyrate, acetyl-CoA levels and nicotinamide adenine dinucleotide (NAD+)/reduced form of NAD+ (NADH) ratios as well as decreased serum lactate levels.Reduction of oxidative stress, upregulation of mitochondrial biogenesis and increase of ketone body metabolism may play a crucial role in preserving neuronal function after CA under short-term DR." @default.
• W3108210009 created "2020-12-07" @default.
• W3108210009 creator A5001756048 @default.
• W3108210009 creator A5049078993 @default.
• W3108210009 creator A5050865078 @default.
• W3108210009 creator A5056241046 @default.
• W3108210009 creator A5066588572 @default.
• W3108210009 creator A5086857601 @default.
• W3108210009 creator A5089396709 @default.
• W3108210009 creator A5091516000 @default.
• W3108210009 date "2021-01-01" @default.
• W3108210009 modified "2023-10-16" @default.
• W3108210009 title "Short-term dietary restriction ameliorates brain injury after cardiac arrest by modulation of mitochondrial biogenesis and energy metabolism in rats" @default.
• W3108210009 cites W152129528 @default.
• W3108210009 cites W1525355751 @default.
• W3108210009 cites W1975625687 @default.
• W3108210009 cites W1975959567 @default.
• W3108210009 cites W1982794774 @default.
• W3108210009 cites W1984098639 @default.
• W3108210009 cites W1985579945 @default.
• W3108210009 cites W1987107881 @default.
• W3108210009 cites W2003814931 @default.
• W3108210009 cites W2012466232 @default.
• W3108210009 cites W2016566261 @default.
• W3108210009 cites W2018444039 @default.
• W3108210009 cites W2032785172 @default.
• W3108210009 cites W2033013746 @default.
• W3108210009 cites W2043401119 @default.
• W3108210009 cites W2056648984 @default.
• W3108210009 cites W2058567239 @default.
• W3108210009 cites W2058768220 @default.
• W3108210009 cites W2058912318 @default.
• W3108210009 cites W2060746511 @default.
• W3108210009 cites W2069405896 @default.
• W3108210009 cites W2078851955 @default.
• W3108210009 cites W2080160572 @default.
• W3108210009 cites W2084708023 @default.
• W3108210009 cites W2084861061 @default.
• W3108210009 cites W2095503394 @default.
• W3108210009 cites W2099270722 @default.
• W3108210009 cites W2104869294 @default.
• W3108210009 cites W2105404724 @default.
• W3108210009 cites W2119284900 @default.
• W3108210009 cites W2127926321 @default.
• W3108210009 cites W2128125964 @default.
• W3108210009 cites W2131193245 @default.
• W3108210009 cites W2144790537 @default.
• W3108210009 cites W2160949539 @default.
• W3108210009 cites W2170633523 @default.
• W3108210009 cites W2292666515 @default.
• W3108210009 cites W2370811705 @default.
• W3108210009 cites W2466124354 @default.
• W3108210009 cites W2512856026 @default.
• W3108210009 cites W2582043308 @default.
• W3108210009 cites W2610767688 @default.
• W3108210009 cites W2768289319 @default.
• W3108210009 cites W2783773694 @default.
• W3108210009 cites W2800606606 @default.
• W3108210009 cites W2885291567 @default.
• W3108210009 cites W2988208233 @default.
• W3108210009 doi "https://doi.org/10.21037/atm-20-3075" @default.
• W3108210009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7859767" @default.
• W3108210009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33553301" @default.
• W3108210009 hasPublicationYear "2021" @default.
• W3108210009 type Work @default.
• W3108210009 sameAs 3108210009 @default.
• W3108210009 citedByCount "1" @default.
• W3108210009 countsByYear W31082100092022 @default.
• W3108210009 crossrefType "journal-article" @default.
• W3108210009 hasAuthorship W3108210009A5001756048 @default.
• W3108210009 hasAuthorship W3108210009A5049078993 @default.
• W3108210009 hasAuthorship W3108210009A5050865078 @default.
• W3108210009 hasAuthorship W3108210009A5056241046 @default.
• W3108210009 hasAuthorship W3108210009A5066588572 @default.
• W3108210009 hasAuthorship W3108210009A5086857601 @default.
• W3108210009 hasAuthorship W3108210009A5089396709 @default.
• W3108210009 hasAuthorship W3108210009A5091516000 @default.
• W3108210009 hasBestOaLocation W31082100091 @default.
• W3108210009 hasConcept C126322002 @default.
• W3108210009 hasConcept C134018914 @default.
• W3108210009 hasConcept C185592680 @default.
• W3108210009 hasConcept C2776151105 @default.
• W3108210009 hasConcept C2777229759 @default.
• W3108210009 hasConcept C28859421 @default.
• W3108210009 hasConcept C37753355 @default.
• W3108210009 hasConcept C48349386 @default.
• W3108210009 hasConcept C54355233 @default.
• W3108210009 hasConcept C55493867 @default.
• W3108210009 hasConcept C71924100 @default.
• W3108210009 hasConcept C74864618 @default.
• W3108210009 hasConcept C86803240 @default.
• W3108210009 hasConceptScore W3108210009C126322002 @default.
• W3108210009 hasConceptScore W3108210009C134018914 @default.
• W3108210009 hasConceptScore W3108210009C185592680 @default.
• W3108210009 hasConceptScore W3108210009C2776151105 @default.
• W3108210009 hasConceptScore W3108210009C2777229759 @default.
• W3108210009 hasConceptScore W3108210009C28859421 @default.
• W3108210009 hasConceptScore W3108210009C37753355 @default.

• next