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- W3108221444 abstract "Abstract Using mass cytometry, we investigated the expression of 28 markers on CD8+ and CD4+ T cells from HIV-1 infected patients with a variable size of HIV-1 reservoir defined as high (HR) and low (LR) reservoir; we aimed at identifying phenotypic associations of T cells with size of HIV-1 reservoir. We showed that the frequency of CD45+ CD8+ and CD4+ T cells was directly proportional to the size of HIV-1 reservoir; HR patients had a significantly larger frequency of blood CD45 high T cells and higher CD45 expression on both CD8+ and CD4+ T cells. CD45 is a receptor-type protein tyrosine phosphatase essential in TCR signaling. Functional and phenotypical analysis of CD45 high cells revealed that they express activation and proliferation markers (CD38 + HLA-DR + and Ki-67) and produce cytokines upon in vitro activation. CD45 high T cells also expressed high levels of immune check-point PD-1. Our results link CD45 expression on T cells to HIV-1 reservoir; PD-1 expression on CD45 high T cells may contribute to their exhaustion." @default.
- W3108221444 created "2020-12-07" @default.
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- W3108221444 date "2020-11-24" @default.
- W3108221444 modified "2023-10-12" @default.
- W3108221444 title "High CD45 expression of CD8+ and CD4+ T cells correlates with the size of HIV-1 reservoir in blood" @default.
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- W3108221444 doi "https://doi.org/10.1038/s41598-020-77433-z" @default.
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