Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108231556> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W3108231556 endingPage "28" @default.
- W3108231556 startingPage "22" @default.
- W3108231556 abstract "Aim. To describe the CNA (Copy Number Aberration) landscape of luminal B breast tumor before treatment. Materials and methods. The study included 100 patients with breast cancer (BC) of luminal B subtype for which a biopsy of the tumor material was performed prior to neoadjuvant chemotherapy (NAC). The tumor DNA was examined using a CytoScan HD Array microarray (Affymetrix, USA). The obtained microarray data were correlated with NAC efficacy. Results. The study showed that loci 1q32.1-32.3, 1q41-42.2, and 8q24.21 had the highest frequency of amplifications (in more than 65% of patients). The highest deletion frequency (in more than 60% of patients) was found in loci 16q21, 16q22.1, 16q23.1-24.1, 17p13.1, and 17p12. Trisomy was most often observed in chromosomes 7, 8, 12, and 17, and monosomy in chromosomes 3, 4, 9, 11, 18, and X-chromosomes. The CNA landscape of luminal B subtype breast tumors is different from triple-negative breast cancer. The largest difference in the frequency of amplifications between patients with an objective response to NAC and patients with no response to NAC was shown in 1q24.2-42.2 loci (46%), and the largest difference in the frequency of deletions (more than 30%) between groups was in regions 6q16. 3, 11p15.4, 11q23.1, and 16q22.2-22.3. These loci can be considered potential predictive markers. Conclusion. The research determined loci with the highest amplification and deletion frequencies for luminal B breast cancer. Potential predictive markers for the given molecular subtype were identified." @default.
- W3108231556 created "2020-12-07" @default.
- W3108231556 creator A5017325034 @default.
- W3108231556 creator A5047964551 @default.
- W3108231556 creator A5083040518 @default.
- W3108231556 creator A5090965653 @default.
- W3108231556 date "2020-10-07" @default.
- W3108231556 modified "2023-10-10" @default.
- W3108231556 title "Aberrations of the number of copies (CNA) in the genome of luminal B breast tumor" @default.
- W3108231556 cites W2000934726 @default.
- W3108231556 cites W2031167624 @default.
- W3108231556 cites W2114505219 @default.
- W3108231556 cites W2168303063 @default.
- W3108231556 cites W2277335334 @default.
- W3108231556 cites W2515472395 @default.
- W3108231556 cites W2525297053 @default.
- W3108231556 cites W2556570155 @default.
- W3108231556 cites W2735540980 @default.
- W3108231556 cites W2758252083 @default.
- W3108231556 doi "https://doi.org/10.20538/1682-0363-2020-3-22-28" @default.
- W3108231556 hasPublicationYear "2020" @default.
- W3108231556 type Work @default.
- W3108231556 sameAs 3108231556 @default.
- W3108231556 citedByCount "2" @default.
- W3108231556 countsByYear W31082315562022 @default.
- W3108231556 countsByYear W31082315562023 @default.
- W3108231556 crossrefType "journal-article" @default.
- W3108231556 hasAuthorship W3108231556A5017325034 @default.
- W3108231556 hasAuthorship W3108231556A5047964551 @default.
- W3108231556 hasAuthorship W3108231556A5083040518 @default.
- W3108231556 hasAuthorship W3108231556A5090965653 @default.
- W3108231556 hasBestOaLocation W31082315561 @default.
- W3108231556 hasConcept C104317684 @default.
- W3108231556 hasConcept C121608353 @default.
- W3108231556 hasConcept C126322002 @default.
- W3108231556 hasConcept C142724271 @default.
- W3108231556 hasConcept C143998085 @default.
- W3108231556 hasConcept C150194340 @default.
- W3108231556 hasConcept C153911025 @default.
- W3108231556 hasConcept C186836561 @default.
- W3108231556 hasConcept C2775934546 @default.
- W3108231556 hasConcept C2776229224 @default.
- W3108231556 hasConcept C2779142324 @default.
- W3108231556 hasConcept C30481170 @default.
- W3108231556 hasConcept C502942594 @default.
- W3108231556 hasConcept C530470458 @default.
- W3108231556 hasConcept C53226629 @default.
- W3108231556 hasConcept C54355233 @default.
- W3108231556 hasConcept C71924100 @default.
- W3108231556 hasConcept C8415881 @default.
- W3108231556 hasConcept C86803240 @default.
- W3108231556 hasConceptScore W3108231556C104317684 @default.
- W3108231556 hasConceptScore W3108231556C121608353 @default.
- W3108231556 hasConceptScore W3108231556C126322002 @default.
- W3108231556 hasConceptScore W3108231556C142724271 @default.
- W3108231556 hasConceptScore W3108231556C143998085 @default.
- W3108231556 hasConceptScore W3108231556C150194340 @default.
- W3108231556 hasConceptScore W3108231556C153911025 @default.
- W3108231556 hasConceptScore W3108231556C186836561 @default.
- W3108231556 hasConceptScore W3108231556C2775934546 @default.
- W3108231556 hasConceptScore W3108231556C2776229224 @default.
- W3108231556 hasConceptScore W3108231556C2779142324 @default.
- W3108231556 hasConceptScore W3108231556C30481170 @default.
- W3108231556 hasConceptScore W3108231556C502942594 @default.
- W3108231556 hasConceptScore W3108231556C530470458 @default.
- W3108231556 hasConceptScore W3108231556C53226629 @default.
- W3108231556 hasConceptScore W3108231556C54355233 @default.
- W3108231556 hasConceptScore W3108231556C71924100 @default.
- W3108231556 hasConceptScore W3108231556C8415881 @default.
- W3108231556 hasConceptScore W3108231556C86803240 @default.
- W3108231556 hasIssue "3" @default.
- W3108231556 hasLocation W31082315561 @default.
- W3108231556 hasOpenAccess W3108231556 @default.
- W3108231556 hasPrimaryLocation W31082315561 @default.
- W3108231556 hasRelatedWork W1911264072 @default.
- W3108231556 hasRelatedWork W1983994322 @default.
- W3108231556 hasRelatedWork W2031181019 @default.
- W3108231556 hasRelatedWork W2031436818 @default.
- W3108231556 hasRelatedWork W2119103177 @default.
- W3108231556 hasRelatedWork W2415824212 @default.
- W3108231556 hasRelatedWork W2550361263 @default.
- W3108231556 hasRelatedWork W2999154782 @default.
- W3108231556 hasRelatedWork W3169740991 @default.
- W3108231556 hasRelatedWork W4232956059 @default.
- W3108231556 hasVolume "19" @default.
- W3108231556 isParatext "false" @default.
- W3108231556 isRetracted "false" @default.
- W3108231556 magId "3108231556" @default.
- W3108231556 workType "article" @default.