Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108256620> ?p ?o ?g. }
- W3108256620 endingPage "8948" @default.
- W3108256620 startingPage "8948" @default.
- W3108256620 abstract "Tauopathies are neurodegenerative diseases characterized by the pathological accumulation of microtubule-associated protein tau (MAPT) in the form of neurofibrillary tangles and paired helical filaments in neurons and glia, leading to brain cell death. These diseases include frontotemporal dementia (FTD) and Alzheimer’s disease (AD) and can be sporadic or inherited when caused by mutations in the MAPT gene. Despite an incredibly high socio-economic burden worldwide, there are still no effective disease-modifying therapies, and few tau-focused experimental drugs have reached clinical trials. One major hindrance for therapeutic development is the knowledge gap in molecular mechanisms of tau-mediated neuronal toxicity and death. For the promise of precision medicine for brain disorders to be fulfilled, it is necessary to integrate known genetic causes of disease, i.e., MAPT mutations, with an understanding of the dysregulated molecular pathways that constitute potential therapeutic targets. Here, the growing understanding of known and proposed mechanisms of disease etiology will be reviewed, together with promising experimental tau-directed therapeutics, such as recently developed tau degraders. Current challenges faced by the fields of tau research and drug discovery will also be addressed." @default.
- W3108256620 created "2020-12-07" @default.
- W3108256620 creator A5014618536 @default.
- W3108256620 creator A5091133537 @default.
- W3108256620 date "2020-11-25" @default.
- W3108256620 modified "2023-10-13" @default.
- W3108256620 title "Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies" @default.
- W3108256620 cites W1432500024 @default.
- W3108256620 cites W1482973910 @default.
- W3108256620 cites W1483889845 @default.
- W3108256620 cites W1512690422 @default.
- W3108256620 cites W1522284801 @default.
- W3108256620 cites W1538925586 @default.
- W3108256620 cites W1544371346 @default.
- W3108256620 cites W1565351177 @default.
- W3108256620 cites W1585083630 @default.
- W3108256620 cites W1587655960 @default.
- W3108256620 cites W1590553747 @default.
- W3108256620 cites W1593967831 @default.
- W3108256620 cites W1601066682 @default.
- W3108256620 cites W1604079405 @default.
- W3108256620 cites W1608504671 @default.
- W3108256620 cites W1725757145 @default.
- W3108256620 cites W1759290616 @default.
- W3108256620 cites W1767023496 @default.
- W3108256620 cites W1954244449 @default.
- W3108256620 cites W1965049154 @default.
- W3108256620 cites W1965402821 @default.
- W3108256620 cites W1965832173 @default.
- W3108256620 cites W1966155352 @default.
- W3108256620 cites W1968276382 @default.
- W3108256620 cites W1968553823 @default.
- W3108256620 cites W1969483518 @default.
- W3108256620 cites W1970606114 @default.
- W3108256620 cites W1971010506 @default.
- W3108256620 cites W1971032265 @default.
- W3108256620 cites W1973921769 @default.
- W3108256620 cites W1975321314 @default.
- W3108256620 cites W1979617336 @default.
- W3108256620 cites W1980768099 @default.
- W3108256620 cites W1981662243 @default.
- W3108256620 cites W1982373527 @default.
- W3108256620 cites W1983119108 @default.
- W3108256620 cites W1983523416 @default.
- W3108256620 cites W1983611639 @default.
- W3108256620 cites W1985581648 @default.
- W3108256620 cites W1985681646 @default.
- W3108256620 cites W1986413832 @default.
- W3108256620 cites W1987927755 @default.
- W3108256620 cites W1989130535 @default.
- W3108256620 cites W1989208474 @default.
- W3108256620 cites W1989369404 @default.
- W3108256620 cites W1989723790 @default.
- W3108256620 cites W1990586782 @default.
- W3108256620 cites W1991185361 @default.
- W3108256620 cites W1994823455 @default.
- W3108256620 cites W1995042437 @default.
- W3108256620 cites W1995139137 @default.
- W3108256620 cites W1998042659 @default.
- W3108256620 cites W1998163143 @default.
- W3108256620 cites W1998344552 @default.
- W3108256620 cites W2001295612 @default.
- W3108256620 cites W2001752726 @default.
- W3108256620 cites W2002659179 @default.
- W3108256620 cites W2004410209 @default.
- W3108256620 cites W2004879508 @default.
- W3108256620 cites W2005483591 @default.
- W3108256620 cites W2005740454 @default.
- W3108256620 cites W2005759199 @default.
- W3108256620 cites W2006345162 @default.
- W3108256620 cites W2006955217 @default.
- W3108256620 cites W2008675281 @default.
- W3108256620 cites W2009033812 @default.
- W3108256620 cites W2009401461 @default.
- W3108256620 cites W2011134915 @default.
- W3108256620 cites W2011634611 @default.
- W3108256620 cites W2012296420 @default.
- W3108256620 cites W2012781495 @default.
- W3108256620 cites W2013339424 @default.
- W3108256620 cites W2015345028 @default.
- W3108256620 cites W2016745163 @default.
- W3108256620 cites W2018908557 @default.
- W3108256620 cites W2020970511 @default.
- W3108256620 cites W2025714022 @default.
- W3108256620 cites W2026263038 @default.
- W3108256620 cites W2026823930 @default.
- W3108256620 cites W2026892692 @default.
- W3108256620 cites W2027619670 @default.
- W3108256620 cites W2027652753 @default.
- W3108256620 cites W2027811359 @default.
- W3108256620 cites W2028383367 @default.
- W3108256620 cites W2030291942 @default.
- W3108256620 cites W2030720587 @default.
- W3108256620 cites W2031259748 @default.
- W3108256620 cites W2032355167 @default.
- W3108256620 cites W2032665165 @default.
- W3108256620 cites W2033349504 @default.
- W3108256620 cites W2034031817 @default.