Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108288547> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3108288547 endingPage "1365" @default.
- W3108288547 startingPage "1354" @default.
- W3108288547 abstract "Background As the third most abundant element, aluminum is widespread in the environment. Previous studies have shown that aluminum has a neurotoxic effect and its exposure can impair neuronal development and cognitive function. Aim To study the effects of aluminum on epigenetic modification in neural stem cells and neurons. Methods Neural stem cells were isolated from the forebrain of adult mice. Neurons were isolated from the hippocampi tissues of embryonic day 16-18 mice. AlCl3 at 100 and 200 μmol/L was applied to stem cells and neurons. Results Aluminum altered the differentiation of adult neural stem cells and caused apoptosis of newborn neurons while having no significant effects on the proliferation of neural stem cells. Aluminum application also significantly inhibited the dendritic development of hippocampal neurons. Mechanistically, aluminum exposure significantly affected the levels of DNA 5-hydroxy-methylcytosine, 5-methylcytosine, and N6-methyladenine in stem cells and neurons. Conclusion Our findings indicate that aluminum may regulate neuronal development by modulating DNA modifications." @default.
- W3108288547 created "2020-12-07" @default.
- W3108288547 creator A5014942240 @default.
- W3108288547 creator A5015146142 @default.
- W3108288547 creator A5050209085 @default.
- W3108288547 creator A5055520219 @default.
- W3108288547 creator A5068646555 @default.
- W3108288547 creator A5072832452 @default.
- W3108288547 date "2020-11-26" @default.
- W3108288547 modified "2023-10-18" @default.
- W3108288547 title "AlCl<sub>3 </sub>exposure regulates neuronal development by modulating DNA modification" @default.
- W3108288547 cites W1836985274 @default.
- W3108288547 cites W1967064280 @default.
- W3108288547 cites W1983951313 @default.
- W3108288547 cites W2001036497 @default.
- W3108288547 cites W2018338317 @default.
- W3108288547 cites W2034969339 @default.
- W3108288547 cites W2038260031 @default.
- W3108288547 cites W2041028481 @default.
- W3108288547 cites W2064756496 @default.
- W3108288547 cites W2073902410 @default.
- W3108288547 cites W2073979766 @default.
- W3108288547 cites W2102535456 @default.
- W3108288547 cites W2108664872 @default.
- W3108288547 cites W2115818350 @default.
- W3108288547 cites W2118121677 @default.
- W3108288547 cites W2121417064 @default.
- W3108288547 cites W2121423419 @default.
- W3108288547 cites W2138370132 @default.
- W3108288547 cites W2141002059 @default.
- W3108288547 cites W2150828607 @default.
- W3108288547 cites W2152451432 @default.
- W3108288547 cites W2210274669 @default.
- W3108288547 cites W2345935812 @default.
- W3108288547 cites W2462857475 @default.
- W3108288547 cites W2587163533 @default.
- W3108288547 cites W2733626821 @default.
- W3108288547 cites W2767011547 @default.
- W3108288547 cites W2808531159 @default.
- W3108288547 cites W2902513420 @default.
- W3108288547 cites W2994762538 @default.
- W3108288547 cites W2999464699 @default.
- W3108288547 doi "https://doi.org/10.4252/wjsc.v12.i11.1354" @default.
- W3108288547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7705460" @default.
- W3108288547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33312403" @default.
- W3108288547 hasPublicationYear "2020" @default.
- W3108288547 type Work @default.
- W3108288547 sameAs 3108288547 @default.
- W3108288547 citedByCount "3" @default.
- W3108288547 countsByYear W31082885472021 @default.
- W3108288547 countsByYear W31082885472022 @default.
- W3108288547 crossrefType "journal-article" @default.
- W3108288547 hasAuthorship W3108288547A5014942240 @default.
- W3108288547 hasAuthorship W3108288547A5015146142 @default.
- W3108288547 hasAuthorship W3108288547A5050209085 @default.
- W3108288547 hasAuthorship W3108288547A5055520219 @default.
- W3108288547 hasAuthorship W3108288547A5068646555 @default.
- W3108288547 hasAuthorship W3108288547A5072832452 @default.
- W3108288547 hasBestOaLocation W31082885471 @default.
- W3108288547 hasConcept C169760540 @default.
- W3108288547 hasConcept C185592680 @default.
- W3108288547 hasConcept C552990157 @default.
- W3108288547 hasConcept C55493867 @default.
- W3108288547 hasConcept C86803240 @default.
- W3108288547 hasConcept C95444343 @default.
- W3108288547 hasConceptScore W3108288547C169760540 @default.
- W3108288547 hasConceptScore W3108288547C185592680 @default.
- W3108288547 hasConceptScore W3108288547C552990157 @default.
- W3108288547 hasConceptScore W3108288547C55493867 @default.
- W3108288547 hasConceptScore W3108288547C86803240 @default.
- W3108288547 hasConceptScore W3108288547C95444343 @default.
- W3108288547 hasIssue "11" @default.
- W3108288547 hasLocation W31082885471 @default.
- W3108288547 hasLocation W31082885472 @default.
- W3108288547 hasOpenAccess W3108288547 @default.
- W3108288547 hasPrimaryLocation W31082885471 @default.
- W3108288547 hasRelatedWork W1531601525 @default.
- W3108288547 hasRelatedWork W1990781990 @default.
- W3108288547 hasRelatedWork W2314643286 @default.
- W3108288547 hasRelatedWork W2606768298 @default.
- W3108288547 hasRelatedWork W2606769243 @default.
- W3108288547 hasRelatedWork W2606837276 @default.
- W3108288547 hasRelatedWork W2748952813 @default.
- W3108288547 hasRelatedWork W2899084033 @default.
- W3108288547 hasRelatedWork W2948807893 @default.
- W3108288547 hasRelatedWork W2778153218 @default.
- W3108288547 hasVolume "12" @default.
- W3108288547 isParatext "false" @default.
- W3108288547 isRetracted "false" @default.
- W3108288547 magId "3108288547" @default.
- W3108288547 workType "article" @default.