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- W3108300012 abstract "Ghrelin has anti-inflammatory and immunomodulatory activities. Data about the role of ghrelin and ghrelin polymorphisms in the development of acne vulgaris in post-adolescent male patients are limited.To evaluate the role of serum androgens, insulin resistance, ghrelin and ghrelin polymorphisms in severe acne vulgaris.Thirty-five post-adolescent male patients with a mean age of 28.0 ±5.4 years and 33 age-and BMI-matched controls were enrolled. Serum androgens, lipids, insulin sensitivity parameters and ghrelin levels were determined. The PCR method was used for GHRL polymorphisms (rs27647, rs696217 and rs34911341 genotypes).Patients had similar anthropometric measures to controls, except a significantly higher WHR in patients (0.92 ±0.06 vs. 0.86 ±0.08, p < 0.05). Also, FPG, HOMA-IR values, lipid profile and serum androgen levels were similar. Interestingly, patients had significantly lower ghrelin levels than controls (4.5 ±5.8 vs. 101.2 ±86.5 pg/ml, p < 0.001). The frequencies of rs696217 and rs34911341 genotypes were similar whereas the distribution of rs27647 alleles was significantly different between the groups (p < 0.05). GA and GG genotypes of GHRL rs27647 polymorphism indicated an increased risk of developing acne vulgaris (OR = 11.156, 95% CI: 2.864-43.464, OR = 5.312, 95% CI: 1.269-22.244, respectively; p < 0.05). Patients with rs27647-AA polymorphism had significantly lower GAGS scores than other groups (AA genotype 6.7 ±14.1 vs. GA genotype 24.6 ±15.7 and GG genotype 19.4 ±17.9, p < 0.001). None of the polymorphisms had a significant effect on metabolic parameters, insulin sensitivity and serum ghrelin levels.Decreased ghrelin levels and GA and GG genotypes of GHRL gene rs27647 polymorphism may have a role in the pathogenesis of acne vulgaris." @default.
- W3108300012 created "2020-12-07" @default.
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- W3108300012 date "2020-01-01" @default.
- W3108300012 modified "2023-10-16" @default.
- W3108300012 title "The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris" @default.
- W3108300012 cites W1211819828 @default.
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- W3108300012 cites W1794483082 @default.
- W3108300012 cites W1913360749 @default.
- W3108300012 cites W1970700403 @default.
- W3108300012 cites W1971883262 @default.
- W3108300012 cites W1977127668 @default.
- W3108300012 cites W1985328809 @default.
- W3108300012 cites W1991333659 @default.
- W3108300012 cites W1995994732 @default.
- W3108300012 cites W2006243205 @default.
- W3108300012 cites W2009545513 @default.
- W3108300012 cites W2014621916 @default.
- W3108300012 cites W2017602185 @default.
- W3108300012 cites W2018608147 @default.
- W3108300012 cites W2038757738 @default.
- W3108300012 cites W2040820188 @default.
- W3108300012 cites W2049055024 @default.
- W3108300012 cites W2051197176 @default.
- W3108300012 cites W2054146977 @default.
- W3108300012 cites W2062145032 @default.
- W3108300012 cites W2064499497 @default.
- W3108300012 cites W2074216525 @default.
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- W3108300012 cites W2116404316 @default.
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- W3108300012 doi "https://doi.org/10.5114/ada.2020.100492" @default.
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