Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108315119> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W3108315119 abstract "Abstract Background Little is known about the prevalence and consequences of cognitive impairment in patients with heart failure and preserved ejection fraction (HFpEF). Purpose To describe the prevalence of cognitive impairment in HFpEF and the association between cognitive function and outcomes in patients with HFpEF. Methods In the Prospective Comparison of ARNI With ARB Global Outcomes in Heart Failure With Preserved Ejection Fraction trial (PARAGON-HF), cognitive function was tested in a subgroup of patients at baseline and during follow-up, using the Mini-Mental State Examination [MMSE] which has a maximum score of 30, with a higher score reflecting better cognitive function. Patients were divided into 3 groups according to baseline score: ≤24 representing cognitive impairment, 25–27 reflecting borderline cognitive impairment and ≥28 normal cognition. The primary endpoint used in this analysis was a composite of first heart failure hospitalization (HFH) or cardiovascular death (CVD). We examined the relationship between baseline MMSE score and this outcome, its components and all-cause mortality. We adjusted for other standard prognostic variables, including NT-proBNP (see Table footnote). Results Among the 2895 patients (60% of total) in PARAGON-HF with a baseline MMSE measurement, 415 (14.3%) had a score ≤24, 671 (23.2%) a score 25–27 and 1809 (62.5%) a score ≥28. Over a median follow-up of 35 (IQR 30–41) months, the unadjusted and adjusted risks of the primary composite (Table), its components and all-cause death (Figure) were higher in patients with lower baseline MMSE scores. Conclusions Even mild cognitive impairment, as measured by the MMSE, is predictive of adverse outcomes in HFpEF Funding Acknowledgement Type of funding source: Private company. Main funding source(s): PARAGON-HF was funded by Novartis Pharma" @default.
- W3108315119 created "2020-12-07" @default.
- W3108315119 creator A5005215114 @default.
- W3108315119 creator A5007353842 @default.
- W3108315119 creator A5009905903 @default.
- W3108315119 creator A5018432247 @default.
- W3108315119 creator A5036821495 @default.
- W3108315119 creator A5039300626 @default.
- W3108315119 creator A5039492344 @default.
- W3108315119 creator A5044740469 @default.
- W3108315119 creator A5047833899 @default.
- W3108315119 creator A5054830306 @default.
- W3108315119 creator A5057204808 @default.
- W3108315119 creator A5069496306 @default.
- W3108315119 creator A5079993448 @default.
- W3108315119 date "2020-11-01" @default.
- W3108315119 modified "2023-10-08" @default.
- W3108315119 title "Reduced cognitive function is associated with poor outcomes in HFpEF: a post hoc analysis from PARAGON-HF" @default.
- W3108315119 doi "https://doi.org/10.1093/ehjci/ehaa946.0867" @default.
- W3108315119 hasPublicationYear "2020" @default.
- W3108315119 type Work @default.
- W3108315119 sameAs 3108315119 @default.
- W3108315119 citedByCount "0" @default.
- W3108315119 crossrefType "journal-article" @default.
- W3108315119 hasAuthorship W3108315119A5005215114 @default.
- W3108315119 hasAuthorship W3108315119A5007353842 @default.
- W3108315119 hasAuthorship W3108315119A5009905903 @default.
- W3108315119 hasAuthorship W3108315119A5018432247 @default.
- W3108315119 hasAuthorship W3108315119A5036821495 @default.
- W3108315119 hasAuthorship W3108315119A5039300626 @default.
- W3108315119 hasAuthorship W3108315119A5039492344 @default.
- W3108315119 hasAuthorship W3108315119A5044740469 @default.
- W3108315119 hasAuthorship W3108315119A5047833899 @default.
- W3108315119 hasAuthorship W3108315119A5054830306 @default.
- W3108315119 hasAuthorship W3108315119A5057204808 @default.
- W3108315119 hasAuthorship W3108315119A5069496306 @default.
- W3108315119 hasAuthorship W3108315119A5079993448 @default.
- W3108315119 hasConcept C118552586 @default.
- W3108315119 hasConcept C126322002 @default.
- W3108315119 hasConcept C164705383 @default.
- W3108315119 hasConcept C169900460 @default.
- W3108315119 hasConcept C2777099384 @default.
- W3108315119 hasConcept C2778198053 @default.
- W3108315119 hasConcept C6057870 @default.
- W3108315119 hasConcept C67761136 @default.
- W3108315119 hasConcept C71924100 @default.
- W3108315119 hasConcept C78085059 @default.
- W3108315119 hasConceptScore W3108315119C118552586 @default.
- W3108315119 hasConceptScore W3108315119C126322002 @default.
- W3108315119 hasConceptScore W3108315119C164705383 @default.
- W3108315119 hasConceptScore W3108315119C169900460 @default.
- W3108315119 hasConceptScore W3108315119C2777099384 @default.
- W3108315119 hasConceptScore W3108315119C2778198053 @default.
- W3108315119 hasConceptScore W3108315119C6057870 @default.
- W3108315119 hasConceptScore W3108315119C67761136 @default.
- W3108315119 hasConceptScore W3108315119C71924100 @default.
- W3108315119 hasConceptScore W3108315119C78085059 @default.
- W3108315119 hasLocation W31083151191 @default.
- W3108315119 hasOpenAccess W3108315119 @default.
- W3108315119 hasPrimaryLocation W31083151191 @default.
- W3108315119 hasRelatedWork W10412033 @default.
- W3108315119 hasRelatedWork W17943206 @default.
- W3108315119 hasRelatedWork W19784077 @default.
- W3108315119 hasRelatedWork W6531563 @default.
- W3108315119 hasRelatedWork W7415202 @default.
- W3108315119 hasRelatedWork W7999385 @default.
- W3108315119 hasRelatedWork W8133324 @default.
- W3108315119 hasRelatedWork W20222777 @default.
- W3108315119 hasRelatedWork W4802238 @default.
- W3108315119 hasRelatedWork W5473191 @default.
- W3108315119 isParatext "false" @default.
- W3108315119 isRetracted "false" @default.
- W3108315119 magId "3108315119" @default.
- W3108315119 workType "article" @default.