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• W3108352528 endingPage "20" @default.
• W3108352528 startingPage "1" @default.
• W3108352528 abstract "Lipopolysaccharides (LPSs or endotoxins) from Gram-negative bacteria represent pathogen-associated molecular patterns (PAMPs) that are recognized by CD14 and Toll-like receptor 4 (TLR4). Lipopolysaccharides prime polymorphonuclear leukocytes (PMNs) for substantial production of reactive oxygen species (ROS) during its response to secondary stimuli such as chemoattractants or pathogens. The excessive ROS production can damage surrounding host tissues, thereby amplifying the inflammatory reaction caused by pathogens. Today, specific antibodies against CD14, TLR4, and CD11b are being used as the essential tools to elucidate the role of these receptors in acute inflammation and some of these antibodies have advised as therapeutic agents for clinical use. Because each antibody has two antigen-binding arms [F(ab <math xmlns=http://www.w3.org/1998/Math/MathML id=M1><msup><mrow /><mrow><mo>′</mo></mrow></msup></math> )2] and one Fc arm, its effect on cellular response is much more complicated rather than simple blockage of target receptor. In fact, IgG antibody, once bound to target receptor, engages Fc receptors γ (FcγRs) and thereby is able to activate the adaptive immune system. The consequences of antibody-dependent binary heterotypic association of CD14, TLR4, or CD11b with FcγRs as well as homotypic one on ROS production are not well elucidated. Moreover, the consequences of antigenic recognition of CD14, TLR4, or CD11b by specific F(ab <math xmlns=http://www.w3.org/1998/Math/MathML id=M2><msup><mrow /><mrow><mo>′</mo></mrow></msup></math> )2 fragments are not always investigated. In this review, we will discuss known mechanisms underlying the therapeutic efficiency of CD14, TLR4, and CD11b/CD18 antibodies with a focus on LPS-dependent ROS or cytokine production by PMNs or monocytes. The impacts of F(ab <math xmlns=http://www.w3.org/1998/Math/MathML id=M3><msup><mrow /><mrow><mo>′</mo></mrow></msup></math> )2 as well as antibody IgG subclasses (isotypes) in therapeutic efficiency or agonistic potency of known antibodies against abovementioned receptors are presented. We also pay attention to how the efficiency of different IgG antibody subclasses is modulated during LPS-induced inflammation and by production of priming agents such as interferon γ (IFN-γ). Our review reinforces the molecular targets and therapeutic approaches to amelioration of harmful consequences of excessive activation of human pattern recognition receptors." @default.
• W3108352528 created "2020-12-07" @default.
• W3108352528 creator A5001456157 @default.
• W3108352528 creator A5020967082 @default.
• W3108352528 creator A5038289656 @default.
• W3108352528 date "2020-11-20" @default.
• W3108352528 modified "2023-10-15" @default.
• W3108352528 title "Monoclonal Antibody to CD14, TLR4, or CD11b: Impact of Epitope and Isotype Specificity on ROS Generation by Human Granulocytes and Monocytes" @default.
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