Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108394704> ?p ?o ?g. }
- W3108394704 abstract "Abstract Collaborator of ARF (CARF) regulates cell proliferative fate through both p53-dependent and -independent mechanisms. Recently, we reported a new function of CARF as a positive regulator of Wnt signaling. Despite these findings, the physiological function of CARF has not been well studied. Here, we generated CARF knockout mice and found that male CARF −/− mice exhibited significantly impaired fertility and Sertoli-cell-only (SCO) syndrome phenotypes. Further studies revealed that loss of CARF in Sertoli cells led to decreased GDNF expression, which hindered spermatogonial stem cells (SSCs) self-renewal. Meanwhile, CARF loss in undifferentiated spermatogonia impaired their proliferation. These two mechanisms together led to SCO syndrome phenotypes, which could be functionally rescued by pharmacological or genetic reactivation of Wnt signaling. Finally, we identified CARF S351F as a potential pathogenic mutation in an SCO patient. Overall, our findings reveal important roles of CARF in spermatogonial self-renewal and proliferation through the Wnt signaling pathway." @default.
- W3108394704 created "2020-12-07" @default.
- W3108394704 creator A5002649440 @default.
- W3108394704 creator A5005929167 @default.
- W3108394704 creator A5008617794 @default.
- W3108394704 creator A5013074988 @default.
- W3108394704 creator A5013601206 @default.
- W3108394704 creator A5046442858 @default.
- W3108394704 creator A5058821625 @default.
- W3108394704 creator A5058861698 @default.
- W3108394704 creator A5062405505 @default.
- W3108394704 creator A5086471424 @default.
- W3108394704 date "2020-11-17" @default.
- W3108394704 modified "2023-10-16" @default.
- W3108394704 title "CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway" @default.
- W3108394704 cites W1498970130 @default.
- W3108394704 cites W1516316082 @default.
- W3108394704 cites W1880406395 @default.
- W3108394704 cites W1963979543 @default.
- W3108394704 cites W1973886069 @default.
- W3108394704 cites W1980244456 @default.
- W3108394704 cites W1980647554 @default.
- W3108394704 cites W1990606472 @default.
- W3108394704 cites W2002120333 @default.
- W3108394704 cites W2017909412 @default.
- W3108394704 cites W2019432819 @default.
- W3108394704 cites W2035711037 @default.
- W3108394704 cites W2043696089 @default.
- W3108394704 cites W2104750827 @default.
- W3108394704 cites W2117199214 @default.
- W3108394704 cites W2118028624 @default.
- W3108394704 cites W2120598012 @default.
- W3108394704 cites W2126679757 @default.
- W3108394704 cites W2128181658 @default.
- W3108394704 cites W2132419180 @default.
- W3108394704 cites W2134207023 @default.
- W3108394704 cites W2142884307 @default.
- W3108394704 cites W2147898515 @default.
- W3108394704 cites W2166069155 @default.
- W3108394704 cites W2187976196 @default.
- W3108394704 cites W2272827471 @default.
- W3108394704 cites W2286124328 @default.
- W3108394704 cites W2289327769 @default.
- W3108394704 cites W2324368371 @default.
- W3108394704 cites W2547510548 @default.
- W3108394704 cites W2600829847 @default.
- W3108394704 cites W2607387172 @default.
- W3108394704 cites W2736362081 @default.
- W3108394704 cites W2791465698 @default.
- W3108394704 cites W2797747269 @default.
- W3108394704 cites W2887103892 @default.
- W3108394704 doi "https://doi.org/10.1038/s41421-020-00212-7" @default.
- W3108394704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7674451" @default.
- W3108394704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33298864" @default.
- W3108394704 hasPublicationYear "2020" @default.
- W3108394704 type Work @default.
- W3108394704 sameAs 3108394704 @default.
- W3108394704 citedByCount "13" @default.
- W3108394704 countsByYear W31083947042021 @default.
- W3108394704 countsByYear W31083947042022 @default.
- W3108394704 countsByYear W31083947042023 @default.
- W3108394704 crossrefType "journal-article" @default.
- W3108394704 hasAuthorship W3108394704A5002649440 @default.
- W3108394704 hasAuthorship W3108394704A5005929167 @default.
- W3108394704 hasAuthorship W3108394704A5008617794 @default.
- W3108394704 hasAuthorship W3108394704A5013074988 @default.
- W3108394704 hasAuthorship W3108394704A5013601206 @default.
- W3108394704 hasAuthorship W3108394704A5046442858 @default.
- W3108394704 hasAuthorship W3108394704A5058821625 @default.
- W3108394704 hasAuthorship W3108394704A5058861698 @default.
- W3108394704 hasAuthorship W3108394704A5062405505 @default.
- W3108394704 hasAuthorship W3108394704A5086471424 @default.
- W3108394704 hasBestOaLocation W31083947041 @default.
- W3108394704 hasConcept C104317684 @default.
- W3108394704 hasConcept C123765429 @default.
- W3108394704 hasConcept C127716648 @default.
- W3108394704 hasConcept C134018914 @default.
- W3108394704 hasConcept C137620995 @default.
- W3108394704 hasConcept C185592680 @default.
- W3108394704 hasConcept C2781068068 @default.
- W3108394704 hasConcept C55493867 @default.
- W3108394704 hasConcept C62478195 @default.
- W3108394704 hasConcept C86803240 @default.
- W3108394704 hasConcept C95444343 @default.
- W3108394704 hasConceptScore W3108394704C104317684 @default.
- W3108394704 hasConceptScore W3108394704C123765429 @default.
- W3108394704 hasConceptScore W3108394704C127716648 @default.
- W3108394704 hasConceptScore W3108394704C134018914 @default.
- W3108394704 hasConceptScore W3108394704C137620995 @default.
- W3108394704 hasConceptScore W3108394704C185592680 @default.
- W3108394704 hasConceptScore W3108394704C2781068068 @default.
- W3108394704 hasConceptScore W3108394704C55493867 @default.
- W3108394704 hasConceptScore W3108394704C62478195 @default.
- W3108394704 hasConceptScore W3108394704C86803240 @default.
- W3108394704 hasConceptScore W3108394704C95444343 @default.
- W3108394704 hasFunder F4320321001 @default.
- W3108394704 hasIssue "1" @default.
- W3108394704 hasLocation W31083947041 @default.
- W3108394704 hasLocation W31083947042 @default.
- W3108394704 hasOpenAccess W3108394704 @default.