Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108432564> ?p ?o ?g. }
- W3108432564 endingPage "10" @default.
- W3108432564 startingPage "1" @default.
- W3108432564 abstract "Plumbagin (PLB), a natural naphthoquinone constituent isolated from the roots of the medicinal plant Plumbago zeylanica L., exhibited anticancer activity against a variety of cancer cell lines including breast cancer, hepatoma, leukemia, melanoma, prostate cancer, brain tumor, tongue squamous cell carcinoma, esophageal cancer, oral squamous cell carcinoma, lung cancer, kidney adenocarcinoma, cholangiocarcinoma, gastric cancer, lymphocyte carcinoma, osteosarcoma, and canine cancer. PLB played anticancer activity via many molecular mechanisms, such as targeting apoptosis, autophagy pathway, cell cycle arrest, antiangiogenesis pathway, anti-invasion, and antimetastasis pathway. Among these signaling pathways, the key regulatory genes regulated by PLB were NF-kβ, STAT3, and AKT. PLB also acted as a potent inducer of reactive oxygen species (ROS), suppressor of cellular glutathione, and novel proteasome inhibitor, causing DNA double-strand break by oxidative DNA base damage. This review comprehensively summarizes the anticancer activity and mechanism of PLB." @default.
- W3108432564 created "2020-12-07" @default.
- W3108432564 creator A5020206515 @default.
- W3108432564 creator A5039913914 @default.
- W3108432564 creator A5041402788 @default.
- W3108432564 creator A5055619738 @default.
- W3108432564 creator A5078143614 @default.
- W3108432564 creator A5083855406 @default.
- W3108432564 creator A5085740747 @default.
- W3108432564 date "2020-12-01" @default.
- W3108432564 modified "2023-10-18" @default.
- W3108432564 title "Anticancer Effects and Mechanisms of Action of Plumbagin: Review of Research Advances" @default.
- W3108432564 cites W1936929899 @default.
- W3108432564 cites W1977369589 @default.
- W3108432564 cites W1984568177 @default.
- W3108432564 cites W1988479401 @default.
- W3108432564 cites W1988887935 @default.
- W3108432564 cites W2001388306 @default.
- W3108432564 cites W2004611644 @default.
- W3108432564 cites W2008372992 @default.
- W3108432564 cites W2009891872 @default.
- W3108432564 cites W2011219499 @default.
- W3108432564 cites W2015709159 @default.
- W3108432564 cites W2020402485 @default.
- W3108432564 cites W2036238945 @default.
- W3108432564 cites W2042889829 @default.
- W3108432564 cites W2052326217 @default.
- W3108432564 cites W2053272914 @default.
- W3108432564 cites W2063013559 @default.
- W3108432564 cites W2081453190 @default.
- W3108432564 cites W2105076167 @default.
- W3108432564 cites W2107842006 @default.
- W3108432564 cites W2114859236 @default.
- W3108432564 cites W2126410297 @default.
- W3108432564 cites W2132433945 @default.
- W3108432564 cites W2138897067 @default.
- W3108432564 cites W2158264437 @default.
- W3108432564 cites W2169925593 @default.
- W3108432564 cites W2192383273 @default.
- W3108432564 cites W2207542692 @default.
- W3108432564 cites W2227263789 @default.
- W3108432564 cites W2254510206 @default.
- W3108432564 cites W2286070056 @default.
- W3108432564 cites W2305175715 @default.
- W3108432564 cites W2315318714 @default.
- W3108432564 cites W2343764145 @default.
- W3108432564 cites W2370766078 @default.
- W3108432564 cites W2400212735 @default.
- W3108432564 cites W2408438171 @default.
- W3108432564 cites W2501012510 @default.
- W3108432564 cites W2508212506 @default.
- W3108432564 cites W2509893298 @default.
- W3108432564 cites W2510388439 @default.
- W3108432564 cites W2512139888 @default.
- W3108432564 cites W2513212960 @default.
- W3108432564 cites W2522707849 @default.
- W3108432564 cites W2531280497 @default.
- W3108432564 cites W2535807734 @default.
- W3108432564 cites W2553513494 @default.
- W3108432564 cites W2577100359 @default.
- W3108432564 cites W2586209381 @default.
- W3108432564 cites W2592971660 @default.
- W3108432564 cites W2599749400 @default.
- W3108432564 cites W2603719919 @default.
- W3108432564 cites W2607293032 @default.
- W3108432564 cites W2607715341 @default.
- W3108432564 cites W2610493810 @default.
- W3108432564 cites W2764232120 @default.
- W3108432564 cites W2766788200 @default.
- W3108432564 cites W2769822615 @default.
- W3108432564 cites W2778226708 @default.
- W3108432564 cites W2783916485 @default.
- W3108432564 cites W2805933602 @default.
- W3108432564 cites W2885516945 @default.
- W3108432564 cites W2886086538 @default.
- W3108432564 cites W2901328308 @default.
- W3108432564 cites W2905014181 @default.
- W3108432564 cites W2914387416 @default.
- W3108432564 cites W2917489859 @default.
- W3108432564 cites W2938280786 @default.
- W3108432564 cites W2943572625 @default.
- W3108432564 cites W2948050931 @default.
- W3108432564 cites W2954371704 @default.
- W3108432564 cites W2957301371 @default.
- W3108432564 cites W2966234620 @default.
- W3108432564 cites W2967502654 @default.
- W3108432564 cites W2969201856 @default.
- W3108432564 cites W2970808599 @default.
- W3108432564 cites W2971417071 @default.
- W3108432564 cites W4248343559 @default.
- W3108432564 cites W783624324 @default.
- W3108432564 doi "https://doi.org/10.1155/2020/6940953" @default.
- W3108432564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7725562" @default.
- W3108432564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33344645" @default.
- W3108432564 hasPublicationYear "2020" @default.
- W3108432564 type Work @default.
- W3108432564 sameAs 3108432564 @default.
- W3108432564 citedByCount "46" @default.