FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108463872> ?p ?o ?g. }

• W3108463872 abstract "Abstract Background A substantial number of elderly patients with aortic stenosis (AS) have been reported to have coexisting transthyretin cardiac amyloidosis (ATTR). These patients are characterized by advanced heart failure symptoms and increased NTproBNP. Raising clinical suspicion of ATTR in AS patients seems difficult. Recent data has shown that an increased apical-basal strain ratio (ABr) derived by echocardiography predicts the diagnosis of cardiac amyloidosis (CA) in patients with left ventricular (LV) hypertrophy. However, the prevalence and prognostic value of ABr, a potential marker of ATTR, in patients with symptomatic AS undergoing transcatheter aortic valve replacement (TAVR) is unknown. The aim of this study was to investigate the preoperative prevalence, relation to symptoms and prognostic implications of elevated ABr in patients with symptomatic AS undergoing TAVR. Methods We obtained data including survival status from 499 consecutive AS patients who underwent TAVR in the period 2016–2018 at our institution. From 2D echocardiographic apical images ABr was calculated as mean longitudinal strain of the 5 LV apical segments divided by the mean of the 6 LV basal segments. Patients were stratified according to ABr; 0–1.9 was considered normal, 2–2.9 mildly increased, 3.0–3.9 moderately increased and ≥4 severely increased. Results Median follow-up time was 743 days. Mean age was 80±7 years. The prevalence of ABr ≥4 was 16% (n=78). These patients had higher preoperative NYHA class (77% were NYHA III or IV compared to 59% in ABr 0–1.9, p=0.003). Median preoperative NTproBNP levels for ABr ≥4 were 1781 pmol/l compared to 876 pmol/l in ABr 0–1.9 (p=0.003). NTproBNP levels decreased for all ABr subgroups at three months follow-up but remained considerably elevated in ABr ≥4 (median of ABr ≥4 was 1262 pmol/l compared to 645 pmol/l for ABr 0–1.9, p=0.001). LV ejection fraction (EF) in ABr 0–1.9 and ≥4 was 50% and 46%, p=0.014. The preoperative aortic valve stenosis severity derived by echo Doppler parameters were comparable across ABr subgroups. Overall, increased ABr ≥4 was associated with poor survival (fig. 1). In univariate analysis ABr ≥4 (HR 1.90, p=0.018), preoperative NTproBNP levels above the median of 1226 pmol/l (HR 3.14, p=0.003), increasing age (HR 1.05, p=0.018), TAPSE &lt;19 mm (HR 1.91, p=0.011) and LV EF &lt;50% (HR 1.60, p=0.045) were significant predictors of mortality. Preoperative NTproBNP &gt;1226 pmol/l emerged as the only significant outcome predictor in a multivariate analysis (HR 2.67, p=0.029). Conclusion Increased ABr ≥4 occurs frequently and is associated with significantly higher pre- and postoperative NYHA class, NTproBNP levels and reduced survival in symptomatic AS patients undergoing TAVR. Some of these patients might have undiagnosed CA. The echocardiographic derived ABr could in future studies prove to be a useful tool in raising suspicion of ATTR leading to referral for diagnostic testing for CA. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Danish Independent Research Fund" @default.
• W3108463872 created "2020-12-07" @default.
• W3108463872 creator A5004475909 @default.
• W3108463872 creator A5015108611 @default.
• W3108463872 creator A5033756615 @default.
• W3108463872 creator A5039002196 @default.
• W3108463872 creator A5040288615 @default.
• W3108463872 creator A5064365116 @default.
• W3108463872 date "2020-11-01" @default.
• W3108463872 modified "2023-09-27" @default.
• W3108463872 title "Prevalence and prognostic implications of increased apical basal strain ratio in aortic stenosis undergoing transcatheter aortic valve replacement" @default.
• W3108463872 doi "https://doi.org/10.1093/ehjci/ehaa946.0062" @default.
• W3108463872 hasPublicationYear "2020" @default.
• W3108463872 type Work @default.
• W3108463872 sameAs 3108463872 @default.
• W3108463872 citedByCount "0" @default.
• W3108463872 crossrefType "journal-article" @default.
• W3108463872 hasAuthorship W3108463872A5004475909 @default.
• W3108463872 hasAuthorship W3108463872A5015108611 @default.
• W3108463872 hasAuthorship W3108463872A5033756615 @default.
• W3108463872 hasAuthorship W3108463872A5039002196 @default.
• W3108463872 hasAuthorship W3108463872A5040288615 @default.
• W3108463872 hasAuthorship W3108463872A5064365116 @default.
• W3108463872 hasBestOaLocation W31084638721 @default.
• W3108463872 hasConcept C126322002 @default.
• W3108463872 hasConcept C164705383 @default.
• W3108463872 hasConcept C2776570981 @default.
• W3108463872 hasConcept C2778024521 @default.
• W3108463872 hasConcept C2778198053 @default.
• W3108463872 hasConcept C2779306644 @default.
• W3108463872 hasConcept C2780007028 @default.
• W3108463872 hasConcept C2780026749 @default.
• W3108463872 hasConcept C2780714102 @default.
• W3108463872 hasConcept C2781414266 @default.
• W3108463872 hasConcept C71924100 @default.
• W3108463872 hasConceptScore W3108463872C126322002 @default.
• W3108463872 hasConceptScore W3108463872C164705383 @default.
• W3108463872 hasConceptScore W3108463872C2776570981 @default.
• W3108463872 hasConceptScore W3108463872C2778024521 @default.
• W3108463872 hasConceptScore W3108463872C2778198053 @default.
• W3108463872 hasConceptScore W3108463872C2779306644 @default.
• W3108463872 hasConceptScore W3108463872C2780007028 @default.
• W3108463872 hasConceptScore W3108463872C2780026749 @default.
• W3108463872 hasConceptScore W3108463872C2780714102 @default.
• W3108463872 hasConceptScore W3108463872C2781414266 @default.
• W3108463872 hasConceptScore W3108463872C71924100 @default.
• W3108463872 hasLocation W31084638721 @default.
• W3108463872 hasOpenAccess W3108463872 @default.
• W3108463872 hasPrimaryLocation W31084638721 @default.
• W3108463872 hasRelatedWork W11274676 @default.
• W3108463872 hasRelatedWork W11635444 @default.
• W3108463872 hasRelatedWork W16473077 @default.
• W3108463872 hasRelatedWork W20032719 @default.
• W3108463872 hasRelatedWork W2495795 @default.
• W3108463872 hasRelatedWork W4290026 @default.
• W3108463872 hasRelatedWork W5516344 @default.
• W3108463872 hasRelatedWork W8633299 @default.
• W3108463872 hasRelatedWork W983181 @default.
• W3108463872 hasRelatedWork W2154344 @default.
• W3108463872 isParatext "false" @default.
• W3108463872 isRetracted "false" @default.
• W3108463872 magId "3108463872" @default.
• W3108463872 workType "article" @default.