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- W3108482920 abstract "Aim. To study perspectives of reducing incidence and severity of coronary artery (CA) restenosis by adding a low dose of antioxidant agent Probucol (250 mg/d) to the treatment before and after transluminal balloon coronary angioplasty (TBCA). Material and methods. The study included 81 patients (mean age 55±6,5 years in Probukol group; 53±6 years in control group; total cholesterol (TCH) level – 6,2±0,66 mmol/l and 6,77±0,79 mmol/l, respectively) with chronic coronary heart disease (CHD), who underwent TBCA and coronaroangiography (CAG) 6 months later. The angiograms were assessed by quantitative computer analysis. Results. In atherosclerosis patients, antioxidant agent Probucol was highly effective not only in the lipid-lowering dose (1000 mg/d), but also in a four-fold reduced dose (250 mg/d). After six-month Probucol treatment (250 mg/d), restenosis incidence was just 19%, comparing to 28% in the control group. In Probucol group, minimal CA lumen diameter was significantly greater, and CA stenosis severity – significantly lower than in control group. Conclusion. The results obtained proved the possibility to reduce restenosis severity by Probucol treatment, even in low dose (250 mg/d), without affecting lipid profile." @default.
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- W3108482920 date "2006-10-20" @default.
- W3108482920 modified "2023-09-25" @default.
- W3108482920 title "Положительное влияние антиоксиданта Пробукола на частоту и степень рестенозирования коронарных артерий после транслюминальной баллонной коронарной ангиопластики" @default.
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