Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108521310> ?p ?o ?g. }
- W3108521310 endingPage "8884" @default.
- W3108521310 startingPage "8884" @default.
- W3108521310 abstract "Intercellular junctions maintain the integrity of the endothelium. We previously found that the adherens and tight junctions between endothelial cells are disrupted by plasma extracellular vesicles from patients with sickle cell disease (especially those with Acute Chest Syndrome). In the current study, we evaluated the effects of these vesicles on endothelial gap junctions. The vesicles from sickle cell patients (isolated during episodes of Acute Chest Syndrome) disrupted gap junction structures earlier and more severely than the other classes of intercellular junctions (as detected by immunofluorescence). These vesicles were much more potent than those isolated at baseline from the same subject. The treatment of endothelial cells with these vesicles led to reduced levels of connexin43 mRNA and protein. These vesicles severely reduced intercellular communication (transfer of microinjected Neurobiotin). Our data suggest a hierarchy of progressive disruption of different intercellular connections between endothelial cells by circulating extracellular vesicles that may contribute to the pathophysiology of the endothelial disturbances in sickle cell disease." @default.
- W3108521310 created "2020-12-07" @default.
- W3108521310 creator A5036927646 @default.
- W3108521310 creator A5051792981 @default.
- W3108521310 creator A5078817433 @default.
- W3108521310 creator A5083328554 @default.
- W3108521310 date "2020-11-24" @default.
- W3108521310 modified "2023-10-16" @default.
- W3108521310 title "Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome" @default.
- W3108521310 cites W1777742992 @default.
- W3108521310 cites W1978634139 @default.
- W3108521310 cites W1980804873 @default.
- W3108521310 cites W1983970047 @default.
- W3108521310 cites W1991312277 @default.
- W3108521310 cites W1992389076 @default.
- W3108521310 cites W2003728637 @default.
- W3108521310 cites W2005817040 @default.
- W3108521310 cites W2022745705 @default.
- W3108521310 cites W2023169392 @default.
- W3108521310 cites W2046609258 @default.
- W3108521310 cites W2068708556 @default.
- W3108521310 cites W2072211192 @default.
- W3108521310 cites W2079362343 @default.
- W3108521310 cites W2083213738 @default.
- W3108521310 cites W2084095280 @default.
- W3108521310 cites W2087709125 @default.
- W3108521310 cites W2090064193 @default.
- W3108521310 cites W2090410143 @default.
- W3108521310 cites W2103435506 @default.
- W3108521310 cites W2104838758 @default.
- W3108521310 cites W2110049914 @default.
- W3108521310 cites W2130639482 @default.
- W3108521310 cites W2131705020 @default.
- W3108521310 cites W2137898197 @default.
- W3108521310 cites W2163530502 @default.
- W3108521310 cites W2262029677 @default.
- W3108521310 cites W2346654466 @default.
- W3108521310 cites W2364988282 @default.
- W3108521310 cites W2477137794 @default.
- W3108521310 cites W2480393309 @default.
- W3108521310 cites W2550916939 @default.
- W3108521310 cites W2580129450 @default.
- W3108521310 cites W2591561423 @default.
- W3108521310 cites W2612321063 @default.
- W3108521310 cites W2616126700 @default.
- W3108521310 cites W2620594759 @default.
- W3108521310 cites W2754310746 @default.
- W3108521310 cites W2765827389 @default.
- W3108521310 cites W2781738339 @default.
- W3108521310 cites W2810624502 @default.
- W3108521310 cites W2891288279 @default.
- W3108521310 cites W2894698763 @default.
- W3108521310 cites W2898014977 @default.
- W3108521310 cites W2988422062 @default.
- W3108521310 cites W2996620173 @default.
- W3108521310 cites W3010813869 @default.
- W3108521310 cites W3029312881 @default.
- W3108521310 cites W3082776786 @default.
- W3108521310 cites W4293247451 @default.
- W3108521310 doi "https://doi.org/10.3390/ijms21238884" @default.
- W3108521310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7727676" @default.
- W3108521310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33255173" @default.
- W3108521310 hasPublicationYear "2020" @default.
- W3108521310 type Work @default.
- W3108521310 sameAs 3108521310 @default.
- W3108521310 citedByCount "6" @default.
- W3108521310 countsByYear W31085213102022 @default.
- W3108521310 countsByYear W31085213102023 @default.
- W3108521310 crossrefType "journal-article" @default.
- W3108521310 hasAuthorship W3108521310A5036927646 @default.
- W3108521310 hasAuthorship W3108521310A5051792981 @default.
- W3108521310 hasAuthorship W3108521310A5078817433 @default.
- W3108521310 hasAuthorship W3108521310A5083328554 @default.
- W3108521310 hasBestOaLocation W31085213101 @default.
- W3108521310 hasConcept C104317684 @default.
- W3108521310 hasConcept C123012128 @default.
- W3108521310 hasConcept C130316041 @default.
- W3108521310 hasConcept C134018914 @default.
- W3108521310 hasConcept C142724271 @default.
- W3108521310 hasConcept C145059251 @default.
- W3108521310 hasConcept C1491633281 @default.
- W3108521310 hasConcept C149402561 @default.
- W3108521310 hasConcept C158157758 @default.
- W3108521310 hasConcept C177779419 @default.
- W3108521310 hasConcept C201508349 @default.
- W3108521310 hasConcept C202751555 @default.
- W3108521310 hasConcept C203014093 @default.
- W3108521310 hasConcept C20518536 @default.
- W3108521310 hasConcept C2776992346 @default.
- W3108521310 hasConcept C2778620579 @default.
- W3108521310 hasConcept C2780976302 @default.
- W3108521310 hasConcept C28406088 @default.
- W3108521310 hasConcept C29350253 @default.
- W3108521310 hasConcept C2992929900 @default.
- W3108521310 hasConcept C41625074 @default.
- W3108521310 hasConcept C55493867 @default.
- W3108521310 hasConcept C71924100 @default.
- W3108521310 hasConcept C79879829 @default.