FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108579226> ?p ?o ?g. }

• W3108579226 abstract "ABSTRACT Importance COVID-19 is a heterogenous disease most frequently causing respiratory tract infection but in its severe forms, respiratory failure and multiple organ dysfunction syndrome may occur, resembling sepsis. The prevalence of viral sepsis among COVID-19 patients is still unclear. Objective We aimed to describe this in a systematic review. Data sources MEDLINE(PubMed), Cochrane and Google Scholar databases were searched for studies reporting on patients hospitalized with confirmed COVID-19, diagnosed with sepsis or infection-related organ dysfunctions or receiving organ replacement therapy. Study selection Eligible were full-text English articles of randomized and non-randomized clinical trials and observational studies reporting on patients with confirmed COVID-19, who are diagnosed with sepsis or have infection-related organ dysfunctions. Systematic reviews, editorials, conference abstracts, animal studies, case reports, articles neither in English nor full-text, and studies with fewer than 30 participants were excluded. Data extraction and synthesis All eligible studies were included in a narrative synthesis of results and after reviewing all included studies a meta-analysis was conducted. Separate sensitivity analyses were conducted per adult vs pediatric populations and per Intensive Care Unit (ICU) vs non-ICU populations. Main outcomes and measures Primary endpoint was the prevalence of sepsis using Sepsis-3 criteria among patients with COVID-19 and among secondary, new onset of infection-related organ dysfunction. Outcomes were expressed as proportions with respective 95% confidence interval (CI). Results Of 1,903 articles, 104 were analyzed. The prevalence of sepsis in COVID-19 was 39.9% (95% CI, 35.9-44.1; I 2 , 99%). In sensitivity analysis, sepsis was present in 25.1% (95% CI, 21.8-28.9; I 2 99%) of adult patients hospitalized in non-Intensive-Care-Unit (ICU) wards (40 studies) and in 83.8 (95% CI, 78.1-88.2; I 2 ,91%) of adult patients hospitalized in the ICU (31 studies). Sepsis in children hospitalized with COVID-19 was as high as 7.8% (95% CI, 0.4-64.9; I 2 , 97%). Acute Respiratory Distress Syndrome was the most common organ dysfunction in adult patients in non-ICU (27.6; 95% CI, 21.6-34.5; I 2 , 99%) and ICU (88.3%; 95% CI, 79.7-93.5; I 2 , 97%) Conclusions and relevance Despite the high heterogeneity in reported results, sepsis frequently complicates COVID-19 among hospitalized patients and is significantly higher among those in the ICU. PROSPERO registration number: CRD42020202018. No funding. KEY POINTS Question What is the prevalence of viral sepsis by Sepsis-3 definition among hospitalized patients with COVID-19? Findings In this systematic review and meta-analysis, we systematically reviewed published literature for evidence of organ failure in COVID-19, to estimate the prevalence of viral sepsis in this setting, by means of SOFA score calculation. The prevalence of sepsis in COVID-19 was 39.9% (95% CI, 35.9-44.1; I 2 , 99%). Meaning This is the first study to address the burden of viral sepsis in hospitalized patients with COVID-19, a highly heterogenous infection ranging from asymptomatic cases to severe disease leading to death, as reflected in the high heterogeneity of this study." @default.
• W3108579226 created "2020-12-07" @default.
• W3108579226 creator A5016776205 @default.
• W3108579226 creator A5027955775 @default.
• W3108579226 creator A5030219128 @default.
• W3108579226 creator A5032877878 @default.
• W3108579226 creator A5037412635 @default.
• W3108579226 creator A5044374817 @default.
• W3108579226 creator A5065659547 @default.
• W3108579226 creator A5072862143 @default.
• W3108579226 date "2020-12-04" @default.
• W3108579226 modified "2023-10-17" @default.
• W3108579226 title "COVID-19 as cause of viral sepsis: A Systematic Review and Meta-Analysis" @default.
• W3108579226 cites W2017044005 @default.
• W3108579226 cites W2148958087 @default.
• W3108579226 cites W2151426785 @default.
• W3108579226 cites W2157823046 @default.
• W3108579226 cites W2161374186 @default.
• W3108579226 cites W2280404143 @default.
• W3108579226 cites W2756170974 @default.
• W3108579226 cites W2768146862 @default.
• W3108579226 cites W2806380259 @default.
• W3108579226 cites W2975424845 @default.
• W3108579226 cites W3001118548 @default.
• W3108579226 cites W3002108456 @default.
• W3108579226 cites W3007114958 @default.
• W3108579226 cites W3007189521 @default.
• W3108579226 cites W3008090866 @default.
• W3108579226 cites W3008827533 @default.
• W3108579226 cites W3009035323 @default.
• W3108579226 cites W3009885589 @default.
• W3108579226 cites W3010951319 @default.
• W3108579226 cites W3012195391 @default.
• W3108579226 cites W3012816616 @default.
• W3108579226 cites W3013034900 @default.
• W3108579226 cites W3013231340 @default.
• W3108579226 cites W3013671288 @default.
• W3108579226 cites W3014092012 @default.
• W3108579226 cites W3015407900 @default.
• W3108579226 cites W3015599879 @default.
• W3108579226 cites W3015877683 @default.
• W3108579226 cites W3016288338 @default.
• W3108579226 cites W3016404849 @default.
• W3108579226 cites W3016570462 @default.
• W3108579226 cites W3016572296 @default.
• W3108579226 cites W3016595631 @default.
• W3108579226 cites W3016771699 @default.
• W3108579226 cites W3017756122 @default.
• W3108579226 cites W3019228824 @default.
• W3108579226 cites W3022060959 @default.
• W3108579226 cites W3022564719 @default.
• W3108579226 cites W3022778033 @default.
• W3108579226 cites W3022809052 @default.
• W3108579226 cites W3023493517 @default.
• W3108579226 cites W3023606094 @default.
• W3108579226 cites W3024114856 @default.
• W3108579226 cites W3024126428 @default.
• W3108579226 cites W3024193040 @default.
• W3108579226 cites W3024769618 @default.
• W3108579226 cites W3024925768 @default.
• W3108579226 cites W3025045885 @default.
• W3108579226 cites W3025282088 @default.
• W3108579226 cites W3025283988 @default.
• W3108579226 cites W3025305522 @default.
• W3108579226 cites W3025490592 @default.
• W3108579226 cites W3025910635 @default.
• W3108579226 cites W3025972894 @default.
• W3108579226 cites W3026005704 @default.
• W3108579226 cites W3026522186 @default.
• W3108579226 cites W3026764413 @default.
• W3108579226 cites W3029656471 @default.
• W3108579226 cites W3030030392 @default.
• W3108579226 cites W3030158388 @default.
• W3108579226 cites W3031152601 @default.
• W3108579226 cites W3031168940 @default.
• W3108579226 cites W3031584350 @default.
• W3108579226 cites W3031830919 @default.
• W3108579226 cites W3032436050 @default.
• W3108579226 cites W3032926677 @default.
• W3108579226 cites W3033029235 @default.
• W3108579226 cites W3033710942 @default.
• W3108579226 cites W3034302252 @default.
• W3108579226 cites W3034534636 @default.
• W3108579226 cites W3034585457 @default.
• W3108579226 cites W3034768431 @default.
• W3108579226 cites W3034965161 @default.
• W3108579226 cites W3035053306 @default.
• W3108579226 cites W3035696387 @default.
• W3108579226 cites W3036133321 @default.
• W3108579226 cites W3036255694 @default.
• W3108579226 cites W3037077950 @default.
• W3108579226 cites W3037544553 @default.
• W3108579226 cites W3037635809 @default.
• W3108579226 cites W3038003713 @default.
• W3108579226 cites W3039233076 @default.
• W3108579226 cites W3039604336 @default.
• W3108579226 cites W3040366309 @default.
• W3108579226 cites W3040801404 @default.
• W3108579226 cites W3040818588 @default.
• W3108579226 cites W3041007898 @default.

• next