Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108592907> ?p ?o ?g. }
- W3108592907 endingPage "1584" @default.
- W3108592907 startingPage "1584" @default.
- W3108592907 abstract "Transition metals interact with a large proportion of the proteome in all forms of life, and they play mandatory and irreplaceable roles. The dynamics of ligand binding to ions of transition metals falls within the realm of Coordination Chemistry, and it provides the basic principles controlling traffic, regulation, and use of metals in cells. Yet, the cellular environment stands out against the conditions prevailing in the test tube when studying metal ions and their interactions with various ligands. Indeed, the complex and often changing cellular environment stimulates fast metal–ligand exchange that mostly escapes presently available probing methods. Reducing the complexity of the problem with purified proteins or in model organisms, although useful, is not free from pitfalls and misleading results. These problems arise mainly from the absence of the biosynthetic machinery and accessory proteins or chaperones dealing with metal / metal groups in cells. Even cells struggle with metal selectivity, as they do not have a metal-directed quality control system for metalloproteins, and serendipitous metal binding is probably not exceptional. The issue of metal exchange in biology is reviewed with particular reference to iron and illustrating examples in patho-physiology, regulation, nutrition, and toxicity." @default.
- W3108592907 created "2020-12-07" @default.
- W3108592907 creator A5072094738 @default.
- W3108592907 date "2020-11-21" @default.
- W3108592907 modified "2023-09-30" @default.
- W3108592907 title "Cellular Dynamics of Transition Metal Exchange on Proteins: A Challenge but a Bonanza for Coordination Chemistry" @default.
- W3108592907 cites W1514136353 @default.
- W3108592907 cites W1549535935 @default.
- W3108592907 cites W1551862901 @default.
- W3108592907 cites W1561207830 @default.
- W3108592907 cites W1578537067 @default.
- W3108592907 cites W1964339096 @default.
- W3108592907 cites W1971037617 @default.
- W3108592907 cites W1971371031 @default.
- W3108592907 cites W1972540879 @default.
- W3108592907 cites W1972606544 @default.
- W3108592907 cites W1973968247 @default.
- W3108592907 cites W1974168690 @default.
- W3108592907 cites W1974649056 @default.
- W3108592907 cites W1977697783 @default.
- W3108592907 cites W1979733076 @default.
- W3108592907 cites W1983234718 @default.
- W3108592907 cites W1984176395 @default.
- W3108592907 cites W1986448811 @default.
- W3108592907 cites W1987816685 @default.
- W3108592907 cites W1992032455 @default.
- W3108592907 cites W1995140521 @default.
- W3108592907 cites W1995846584 @default.
- W3108592907 cites W1995966908 @default.
- W3108592907 cites W1999166320 @default.
- W3108592907 cites W2000312093 @default.
- W3108592907 cites W2003890109 @default.
- W3108592907 cites W2004514381 @default.
- W3108592907 cites W2008326745 @default.
- W3108592907 cites W2010680563 @default.
- W3108592907 cites W2010883644 @default.
- W3108592907 cites W2016781886 @default.
- W3108592907 cites W2017980572 @default.
- W3108592907 cites W2018478627 @default.
- W3108592907 cites W2022365548 @default.
- W3108592907 cites W2024431569 @default.
- W3108592907 cites W2026660014 @default.
- W3108592907 cites W2028834338 @default.
- W3108592907 cites W2034734617 @default.
- W3108592907 cites W2038402717 @default.
- W3108592907 cites W2040346754 @default.
- W3108592907 cites W2042401576 @default.
- W3108592907 cites W2043986265 @default.
- W3108592907 cites W2047943139 @default.
- W3108592907 cites W2048805199 @default.
- W3108592907 cites W2050828231 @default.
- W3108592907 cites W2053649957 @default.
- W3108592907 cites W2060383405 @default.
- W3108592907 cites W2061488891 @default.
- W3108592907 cites W2064186839 @default.
- W3108592907 cites W2067704515 @default.
- W3108592907 cites W2077108160 @default.
- W3108592907 cites W2079075712 @default.
- W3108592907 cites W2082038436 @default.
- W3108592907 cites W2088420005 @default.
- W3108592907 cites W2088423175 @default.
- W3108592907 cites W2101832278 @default.
- W3108592907 cites W2107682629 @default.
- W3108592907 cites W2110408216 @default.
- W3108592907 cites W2111006624 @default.
- W3108592907 cites W2113978811 @default.
- W3108592907 cites W2115297948 @default.
- W3108592907 cites W2132614547 @default.
- W3108592907 cites W2138719091 @default.
- W3108592907 cites W2145531115 @default.
- W3108592907 cites W2147177078 @default.
- W3108592907 cites W2151368213 @default.
- W3108592907 cites W2152733087 @default.
- W3108592907 cites W2165966788 @default.
- W3108592907 cites W2171941574 @default.
- W3108592907 cites W2225938139 @default.
- W3108592907 cites W2230074349 @default.
- W3108592907 cites W2276088525 @default.
- W3108592907 cites W2279951496 @default.
- W3108592907 cites W2290932723 @default.
- W3108592907 cites W2337794700 @default.
- W3108592907 cites W2401130360 @default.
- W3108592907 cites W2404778456 @default.
- W3108592907 cites W2412900915 @default.
- W3108592907 cites W2423208326 @default.
- W3108592907 cites W2471362850 @default.
- W3108592907 cites W2484263962 @default.
- W3108592907 cites W2515174513 @default.
- W3108592907 cites W2520138767 @default.
- W3108592907 cites W2551578447 @default.
- W3108592907 cites W2588505129 @default.
- W3108592907 cites W2597215499 @default.
- W3108592907 cites W2616006179 @default.
- W3108592907 cites W2626930474 @default.
- W3108592907 cites W2728934083 @default.
- W3108592907 cites W2748787709 @default.
- W3108592907 cites W2756641028 @default.
- W3108592907 cites W2762087180 @default.