Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108634609> ?p ?o ?g. }
- W3108634609 abstract "In the study reported here, polylactic acid (PLLA) polymer was synthesized using stannous octoate (Sn(Oct) 2) and N-(t-butoxycarbonyl) ethanolamine (EABoc) as the catalyst and the initiator, respectively. The selected PLLA polymer with proper molecular weight was used to prepare nanobubbles encapsulating with liquid perfluoropentane. Then, lactoferrin (Lf), which has a good affinity with tumor cells, was conjugated to PLLA nanobubbles. The resulting Lf–PLLA nanobubbles were examined from the perspective of appearance, size, zeta potential, and stability in vitro . The average hydrodynamic diameter of the Lf–PLLA nanobubbles was 315.3 ± 4.2 nm, the polydispersity index (PDI) was 0.153 ± 0.020, and the zeta potential was around −11.3 ± 0.2 mV. Under the transmission electron microscope (TEM), Lf–PLLA nanobubbles were highly dispersed and had a spherical shape with a distinct capsule structure. The Lf–PLLA nanobubbles also showed little cytotoxicity and low hemolysis rate and exhibited good stability in vitro . The enhanced ultrasound imaging ability of Lf–PLLA nanobubbles was detected by an ultrasound imaging system. The results of ultrasound studies in vitro showed that the liquid perfluoropentane underwent phase transition under ultrasonic treatment, which proved the Lf–PLLA nanobubbles could enhance the ability of ultrasonic imaging. The studies of ultrasonic imaging in nude mice bearing subcutaneous tumors showed that the ability of enhanced ultrasonic images was apparent after injection of Lf–PLLA nanobubbles. Acoustic behavior in vitro and in vivo showed that the Lf–PLLA nanobubbles were characterized by strong, stabilized, and the ability of tumor-enhanced ultrasound imaging. Thus, the Lf–PLLA nanobubbles are an effective ultrasound contrast agent for contrast-enhanced imaging." @default.
- W3108634609 created "2020-12-07" @default.
- W3108634609 creator A5002700038 @default.
- W3108634609 creator A5012262125 @default.
- W3108634609 creator A5014415657 @default.
- W3108634609 creator A5082138899 @default.
- W3108634609 creator A5085564047 @default.
- W3108634609 creator A5089491942 @default.
- W3108634609 creator A5090305166 @default.
- W3108634609 date "2020-12-04" @default.
- W3108634609 modified "2023-10-17" @default.
- W3108634609 title "Preparation and Ultrasonic Imaging Investigation of Perfluoropentane-Filled Polylactic Acid Nanobubbles As a Novel Targeted Ultrasound Contrast Agent" @default.
- W3108634609 cites W1747469260 @default.
- W3108634609 cites W1758094775 @default.
- W3108634609 cites W1969445542 @default.
- W3108634609 cites W1982685998 @default.
- W3108634609 cites W2007347895 @default.
- W3108634609 cites W2014125242 @default.
- W3108634609 cites W2031419583 @default.
- W3108634609 cites W2037015591 @default.
- W3108634609 cites W2049682101 @default.
- W3108634609 cites W2068640464 @default.
- W3108634609 cites W2095325031 @default.
- W3108634609 cites W2134049461 @default.
- W3108634609 cites W2198090369 @default.
- W3108634609 cites W2224303249 @default.
- W3108634609 cites W2280918202 @default.
- W3108634609 cites W2307269021 @default.
- W3108634609 cites W2416929336 @default.
- W3108634609 cites W2525963926 @default.
- W3108634609 cites W2549471684 @default.
- W3108634609 cites W2568847092 @default.
- W3108634609 cites W2594901836 @default.
- W3108634609 cites W2610148417 @default.
- W3108634609 cites W2620238924 @default.
- W3108634609 cites W2622515924 @default.
- W3108634609 cites W2736442509 @default.
- W3108634609 cites W2757887072 @default.
- W3108634609 cites W2762336168 @default.
- W3108634609 cites W2783104108 @default.
- W3108634609 cites W2790591135 @default.
- W3108634609 cites W2806533169 @default.
- W3108634609 cites W2886658179 @default.
- W3108634609 cites W2895803636 @default.
- W3108634609 cites W2896190356 @default.
- W3108634609 cites W2901701314 @default.
- W3108634609 cites W2931189986 @default.
- W3108634609 cites W2946550020 @default.
- W3108634609 doi "https://doi.org/10.3389/fmats.2020.549002" @default.
- W3108634609 hasPublicationYear "2020" @default.
- W3108634609 type Work @default.
- W3108634609 sameAs 3108634609 @default.
- W3108634609 citedByCount "3" @default.
- W3108634609 countsByYear W31086346092021 @default.
- W3108634609 countsByYear W31086346092022 @default.
- W3108634609 countsByYear W31086346092023 @default.
- W3108634609 crossrefType "journal-article" @default.
- W3108634609 hasAuthorship W3108634609A5002700038 @default.
- W3108634609 hasAuthorship W3108634609A5012262125 @default.
- W3108634609 hasAuthorship W3108634609A5014415657 @default.
- W3108634609 hasAuthorship W3108634609A5082138899 @default.
- W3108634609 hasAuthorship W3108634609A5085564047 @default.
- W3108634609 hasAuthorship W3108634609A5089491942 @default.
- W3108634609 hasAuthorship W3108634609A5090305166 @default.
- W3108634609 hasBestOaLocation W31086346091 @default.
- W3108634609 hasConcept C11432220 @default.
- W3108634609 hasConcept C121332964 @default.
- W3108634609 hasConcept C12554922 @default.
- W3108634609 hasConcept C136229726 @default.
- W3108634609 hasConcept C143753070 @default.
- W3108634609 hasConcept C146088050 @default.
- W3108634609 hasConcept C150903083 @default.
- W3108634609 hasConcept C155672457 @default.
- W3108634609 hasConcept C159985019 @default.
- W3108634609 hasConcept C171250308 @default.
- W3108634609 hasConcept C188027245 @default.
- W3108634609 hasConcept C192562407 @default.
- W3108634609 hasConcept C207001950 @default.
- W3108634609 hasConcept C24890656 @default.
- W3108634609 hasConcept C2781162966 @default.
- W3108634609 hasConcept C521977710 @default.
- W3108634609 hasConcept C71924100 @default.
- W3108634609 hasConcept C81288441 @default.
- W3108634609 hasConcept C86181022 @default.
- W3108634609 hasConcept C86803240 @default.
- W3108634609 hasConceptScore W3108634609C11432220 @default.
- W3108634609 hasConceptScore W3108634609C121332964 @default.
- W3108634609 hasConceptScore W3108634609C12554922 @default.
- W3108634609 hasConceptScore W3108634609C136229726 @default.
- W3108634609 hasConceptScore W3108634609C143753070 @default.
- W3108634609 hasConceptScore W3108634609C146088050 @default.
- W3108634609 hasConceptScore W3108634609C150903083 @default.
- W3108634609 hasConceptScore W3108634609C155672457 @default.
- W3108634609 hasConceptScore W3108634609C159985019 @default.
- W3108634609 hasConceptScore W3108634609C171250308 @default.
- W3108634609 hasConceptScore W3108634609C188027245 @default.
- W3108634609 hasConceptScore W3108634609C192562407 @default.
- W3108634609 hasConceptScore W3108634609C207001950 @default.
- W3108634609 hasConceptScore W3108634609C24890656 @default.
- W3108634609 hasConceptScore W3108634609C2781162966 @default.