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- W3108637434 abstract "Abnormal angiogenesis is associated with intraocular diseases such as proliferative diabetic retinopathy and neovascular age-related macular degeneration, and current therapies for these eye diseases are not satisfactory. The purpose of this study was to determine whether capilliposide B (CPS-B), a novel oleanane triterpenoid saponin derived from Lysimachia capillipes Hemsl, can inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis signaling events and cellular responses in primary human retinal microvascular endothelial cells (HRECs). Our study revealed that the capilliposide B IC50 for HRECs was 8.5 μM at 72 h and that 1 μM capilliposide B specifically inhibited VEGF-induced activation of VEGFR2 and its downstream signaling enzymes Akt and Erk. In addition, we discovered that this chemical effectively blocked VEGF-stimulated proliferation, migration and tube formation of the HRECs, suggesting that capilliposide B is a promising prophylactic for angiogenesis-associated diseases such as proliferative diabetic retinopathy." @default.
- W3108637434 created "2020-12-07" @default.
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- W3108637434 date "2021-01-01" @default.
- W3108637434 modified "2023-10-12" @default.
- W3108637434 title "Capilliposide B blocks VEGF-induced angiogenesis in vitro in primary human retinal microvascular endothelial cells" @default.
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- W3108637434 doi "https://doi.org/10.1016/j.biopha.2020.110999" @default.
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