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- W3108648049 startingPage "581" @default.
- W3108648049 abstract "The symbiosis between the gut microbiota and the host has been identified as an integral part of normal human physiology and physiological development. Research in germ-free or gnotobiotic animals has demonstrated the importance of this symbiosis in immune, vascular, hepatic, respiratory and metabolic systems. Disruption of the microbiota can also contribute to disease, and the microbiota has been implicated in numerous intestinal and extra-intestinal pathologies including colorectal cancer. Interactions between host and microbiota can occur either directly or indirectly, via microbial-derived metabolites. In this chapter, we focus on two major products of microbial metabolism, short-chain fatty acids and bile acids, and their role in colorectal cancer. Short-chain fatty acids are the products of microbial fermentation of complex carbohydrates and confer protection against cancer risk, while bile acids are compounds which are endogenous to the host, but undergo microbial modification in the large intestine leading to alterations in their bioactivity. Lastly, we discuss the ability of microbial modulation to mediate cancer risk and the potential to harness this ability as a prophylactic or therapeutic treatment in colorectal cancer." @default.
- W3108648049 created "2020-12-07" @default.
- W3108648049 creator A5003508542 @default.
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- W3108648049 creator A5015330935 @default.
- W3108648049 creator A5069134006 @default.
- W3108648049 creator A5080963402 @default.
- W3108648049 date "2020-01-01" @default.
- W3108648049 modified "2023-09-27" @default.
- W3108648049 title "Microbial Metabolites as Molecular Mediators of Host-Microbe Symbiosis in Colorectal Cancer" @default.
- W3108648049 cites W1597214954 @default.
- W3108648049 cites W1862711637 @default.
- W3108648049 cites W1877854700 @default.
- W3108648049 cites W1922079366 @default.
- W3108648049 cites W1922511005 @default.
- W3108648049 cites W1940354221 @default.
- W3108648049 cites W1965554634 @default.
- W3108648049 cites W1966340941 @default.
- W3108648049 cites W1967665214 @default.
- W3108648049 cites W1968341780 @default.
- W3108648049 cites W1971000774 @default.
- W3108648049 cites W1971857522 @default.
- W3108648049 cites W1972173502 @default.
- W3108648049 cites W1974893818 @default.
- W3108648049 cites W1975391560 @default.
- W3108648049 cites W1979080859 @default.
- W3108648049 cites W1980764720 @default.
- W3108648049 cites W1988036805 @default.
- W3108648049 cites W1988439456 @default.
- W3108648049 cites W1989086831 @default.
- W3108648049 cites W1989407179 @default.
- W3108648049 cites W1992766527 @default.
- W3108648049 cites W1994017345 @default.
- W3108648049 cites W1994687037 @default.
- W3108648049 cites W1994993924 @default.
- W3108648049 cites W1995133050 @default.
- W3108648049 cites W1995953530 @default.
- W3108648049 cites W1996368825 @default.
- W3108648049 cites W1996995529 @default.
- W3108648049 cites W1999336640 @default.
- W3108648049 cites W1999477419 @default.
- W3108648049 cites W2000002900 @default.
- W3108648049 cites W2001128294 @default.
- W3108648049 cites W2001884635 @default.
- W3108648049 cites W2010139512 @default.
- W3108648049 cites W2012065014 @default.
- W3108648049 cites W2013882596 @default.
- W3108648049 cites W2013917130 @default.
- W3108648049 cites W2016375372 @default.
- W3108648049 cites W2016507693 @default.
- W3108648049 cites W2018592420 @default.
- W3108648049 cites W2018620221 @default.
- W3108648049 cites W2022380356 @default.
- W3108648049 cites W2023328619 @default.
- W3108648049 cites W2026700702 @default.
- W3108648049 cites W2029180586 @default.
- W3108648049 cites W2031801942 @default.
- W3108648049 cites W2034980611 @default.
- W3108648049 cites W2038217946 @default.
- W3108648049 cites W2040497161 @default.
- W3108648049 cites W2044376891 @default.
- W3108648049 cites W2044511863 @default.
- W3108648049 cites W2045871364 @default.
- W3108648049 cites W2046931787 @default.
- W3108648049 cites W2046976278 @default.
- W3108648049 cites W2047711197 @default.
- W3108648049 cites W2051115786 @default.
- W3108648049 cites W2053581007 @default.
- W3108648049 cites W2053735298 @default.
- W3108648049 cites W2058496105 @default.
- W3108648049 cites W2060754769 @default.
- W3108648049 cites W2063441241 @default.
- W3108648049 cites W2063935485 @default.
- W3108648049 cites W2068052387 @default.
- W3108648049 cites W2068140733 @default.
- W3108648049 cites W2069896919 @default.
- W3108648049 cites W2074141788 @default.
- W3108648049 cites W2077027532 @default.
- W3108648049 cites W2077171036 @default.
- W3108648049 cites W2077956757 @default.
- W3108648049 cites W2078770291 @default.
- W3108648049 cites W2080598921 @default.
- W3108648049 cites W2081338075 @default.
- W3108648049 cites W2081900895 @default.
- W3108648049 cites W2082101278 @default.
- W3108648049 cites W2082578477 @default.
- W3108648049 cites W2086248022 @default.
- W3108648049 cites W2087369082 @default.
- W3108648049 cites W2088170171 @default.
- W3108648049 cites W2091564291 @default.
- W3108648049 cites W2092452156 @default.
- W3108648049 cites W2095870639 @default.
- W3108648049 cites W2097783355 @default.
- W3108648049 cites W2097875133 @default.
- W3108648049 cites W2100396630 @default.
- W3108648049 cites W2107097628 @default.
- W3108648049 cites W2110235509 @default.
- W3108648049 cites W2115291659 @default.