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- W3108667002 abstract "Since its discovery in the early 1950s, intracranial self-stimulation (ICSS) has proved valuable in studying the brain reward circuitry. This behavior was serendipitously discovered by Olds and Milner at McGill University who noticed that laboratory animals would readily learn to self-administer pulses of electrical stimulation in septal regions of the brain. Till the present day, numerous laboratories worldwide are using ICSS to delineate brain regions and pathways that are involved in processing information related to reward. Such work could lead to improved understanding and new therapeutic strategies not only for psychiatric diseases such as depression and substance use disorder but also for schizophrenia and Parkinson’s disease. This chapter provides a detailed description of the ICSS behavior in experimental animals and how it is used for studying the brain reward pathway." @default.
- W3108667002 created "2020-12-07" @default.
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- W3108667002 date "2020-12-03" @default.
- W3108667002 modified "2023-10-01" @default.
- W3108667002 title "Intracranial Self-Stimulation and the Curve-Shift Paradigm: A Putative Model to Study the Brain Reward System" @default.
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- W3108667002 doi "https://doi.org/10.1007/978-1-0716-1146-3_1" @default.
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