Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108667683> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3108667683 abstract "Abstract Background The protective effect of obesity on mortality in acute coronary syndromes (ACS) patients remains debated. We aimed at evaluating the impact of obesity on ischemic and bleeding events as possible explanations to the obesity paradox in ACS patients. Methods For the purpose of this sub-study, patients enrolled in the START-ANTIPLATELET registry were stratified according to Body Mass Index (BMI) into three groups: normal, BMI <25kg/m2; overweight, BMI: 25–29.9kg/m2; obese, BMI ≥30kg/m2. The primary endpoint was net adverse clinical endpoints (NACE), defined as a composite of all-cause death, myocardial infarction (MI), stroke, and major bleeding. Results Patients were classified as follows: 410 (33.9%) normal, 538 (44.5%) overweight, 261 (21.6%) obese. Compared to the normal weight group, obese and overweight patients had a higher prevalence of cardiovascular risk factors, but were younger, with a better left ventricular ejection fraction (LVEF) and lower PRECISE-DAPT score. At one-year follow-up NACE was more frequently observed in normal than in overweight and obese patients (15.1%,8.6%,and9.6%, respectively; p=0.004), driven by a significantly higher rate of all-cause death (6.3%,2.6%, and 3.8%, respectively; p=0.008), while no significant differences were noted in terms of MI, stroke, and major bleeding. When correcting for confounding variables, BMI loses its power in independently predicting outcomes, failing to confirm the obesity paradox in a real-world ACS population. Conclusions Our study conflicts the obesity paradox in real-world ACS population, and suggest that the reduced mortality rate may be explained by a lower bleeding risk in obese patients allowing a more aggressive medical treatment, and by a better LVEF translating into a higher survival rate. Funding Acknowledgement Type of funding source: None" @default.
- W3108667683 created "2020-12-07" @default.
- W3108667683 creator A5000200390 @default.
- W3108667683 creator A5003292078 @default.
- W3108667683 creator A5006406707 @default.
- W3108667683 creator A5008150148 @default.
- W3108667683 creator A5025539088 @default.
- W3108667683 creator A5027649822 @default.
- W3108667683 creator A5028646700 @default.
- W3108667683 creator A5033373672 @default.
- W3108667683 creator A5048328215 @default.
- W3108667683 creator A5055365537 @default.
- W3108667683 creator A5055583365 @default.
- W3108667683 creator A5067848534 @default.
- W3108667683 creator A5068374739 @default.
- W3108667683 creator A5070057174 @default.
- W3108667683 creator A5075635455 @default.
- W3108667683 date "2020-11-01" @default.
- W3108667683 modified "2023-10-14" @default.
- W3108667683 title "Effect of body mass index on ischemic and bleeding events in patients presenting with acute coronary syndromes: insights from the START-ANTIPLATELET registry" @default.
- W3108667683 doi "https://doi.org/10.1093/ehjci/ehaa946.1720" @default.
- W3108667683 hasPublicationYear "2020" @default.
- W3108667683 type Work @default.
- W3108667683 sameAs 3108667683 @default.
- W3108667683 citedByCount "0" @default.
- W3108667683 crossrefType "journal-article" @default.
- W3108667683 hasAuthorship W3108667683A5000200390 @default.
- W3108667683 hasAuthorship W3108667683A5003292078 @default.
- W3108667683 hasAuthorship W3108667683A5006406707 @default.
- W3108667683 hasAuthorship W3108667683A5008150148 @default.
- W3108667683 hasAuthorship W3108667683A5025539088 @default.
- W3108667683 hasAuthorship W3108667683A5027649822 @default.
- W3108667683 hasAuthorship W3108667683A5028646700 @default.
- W3108667683 hasAuthorship W3108667683A5033373672 @default.
- W3108667683 hasAuthorship W3108667683A5048328215 @default.
- W3108667683 hasAuthorship W3108667683A5055365537 @default.
- W3108667683 hasAuthorship W3108667683A5055583365 @default.
- W3108667683 hasAuthorship W3108667683A5067848534 @default.
- W3108667683 hasAuthorship W3108667683A5068374739 @default.
- W3108667683 hasAuthorship W3108667683A5070057174 @default.
- W3108667683 hasAuthorship W3108667683A5075635455 @default.
- W3108667683 hasConcept C126322002 @default.
- W3108667683 hasConcept C127413603 @default.
- W3108667683 hasConcept C164705383 @default.
- W3108667683 hasConcept C168563851 @default.
- W3108667683 hasConcept C203092338 @default.
- W3108667683 hasConcept C2778198053 @default.
- W3108667683 hasConcept C2780221984 @default.
- W3108667683 hasConcept C2780586474 @default.
- W3108667683 hasConcept C2780645631 @default.
- W3108667683 hasConcept C2781223611 @default.
- W3108667683 hasConcept C2908647359 @default.
- W3108667683 hasConcept C500558357 @default.
- W3108667683 hasConcept C511355011 @default.
- W3108667683 hasConcept C71924100 @default.
- W3108667683 hasConcept C77350462 @default.
- W3108667683 hasConcept C78085059 @default.
- W3108667683 hasConcept C78519656 @default.
- W3108667683 hasConcept C99454951 @default.
- W3108667683 hasConceptScore W3108667683C126322002 @default.
- W3108667683 hasConceptScore W3108667683C127413603 @default.
- W3108667683 hasConceptScore W3108667683C164705383 @default.
- W3108667683 hasConceptScore W3108667683C168563851 @default.
- W3108667683 hasConceptScore W3108667683C203092338 @default.
- W3108667683 hasConceptScore W3108667683C2778198053 @default.
- W3108667683 hasConceptScore W3108667683C2780221984 @default.
- W3108667683 hasConceptScore W3108667683C2780586474 @default.
- W3108667683 hasConceptScore W3108667683C2780645631 @default.
- W3108667683 hasConceptScore W3108667683C2781223611 @default.
- W3108667683 hasConceptScore W3108667683C2908647359 @default.
- W3108667683 hasConceptScore W3108667683C500558357 @default.
- W3108667683 hasConceptScore W3108667683C511355011 @default.
- W3108667683 hasConceptScore W3108667683C71924100 @default.
- W3108667683 hasConceptScore W3108667683C77350462 @default.
- W3108667683 hasConceptScore W3108667683C78085059 @default.
- W3108667683 hasConceptScore W3108667683C78519656 @default.
- W3108667683 hasConceptScore W3108667683C99454951 @default.
- W3108667683 hasLocation W31086676831 @default.
- W3108667683 hasOpenAccess W3108667683 @default.
- W3108667683 hasPrimaryLocation W31086676831 @default.
- W3108667683 hasRelatedWork W10539617 @default.
- W3108667683 hasRelatedWork W15973869 @default.
- W3108667683 hasRelatedWork W20272975 @default.
- W3108667683 hasRelatedWork W21063540 @default.
- W3108667683 hasRelatedWork W2862113 @default.
- W3108667683 hasRelatedWork W4447781 @default.
- W3108667683 hasRelatedWork W7331692 @default.
- W3108667683 hasRelatedWork W890575 @default.
- W3108667683 hasRelatedWork W12950104 @default.
- W3108667683 hasRelatedWork W6726199 @default.
- W3108667683 isParatext "false" @default.
- W3108667683 isRetracted "false" @default.
- W3108667683 magId "3108667683" @default.
- W3108667683 workType "article" @default.