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- W3108722944 endingPage "120572" @default.
- W3108722944 startingPage "120572" @default.
- W3108722944 abstract "Mechanobiology, translating mechanical signals into biological ones, greatly affects cellular behavior. Steering cellular behavior for cell-based regenerative medicine approaches requires a thorough understanding of the orchestrating molecular mechanisms, among which mechanotransducive ones are being more and more elucidated. Because of their wide use and highly mechanotransduction dependent differentiation, this review focuses on mesenchymal stromal cells (MSCs), while also briefly relating the discussed results to other cell types. While the mechanotransduction pathways are relatively well-studied in 2D, much remains unknown of the role and regulation of these pathways in 3D. Ultimately, cells need to be cultured in a 3D environment to create functional de novo tissue. In this review, we explore the literature on the roles of different material properties on cellular behavior and mechanobiology in 2D and 3D. For example, while stiffness plays a dominant role in 2D MSCs differentiation, it seems to be of subordinate importance in 3D MSCs differentiation, where matrix remodeling seems to be key. Also, the role and regulation of some of the main mechanotransduction players are discussed, focusing on MSCs. We have only just begun to fundamentally understand MSCs and other stem cells behavior in 3D and more fundamental research is required to advance biomaterials able to replicate the stem cell niche and control cell activity. This better understanding will contribute to smarter tissue engineering scaffold design and the advancement of regenerative medicine." @default.
- W3108722944 created "2020-12-07" @default.
- W3108722944 creator A5058423562 @default.
- W3108722944 creator A5075416325 @default.
- W3108722944 date "2021-01-01" @default.
- W3108722944 modified "2023-10-16" @default.
- W3108722944 title "Steering cell behavior through mechanobiology in 3D: A regenerative medicine perspective" @default.
- W3108722944 cites W1553351438 @default.
- W3108722944 cites W1567806690 @default.
- W3108722944 cites W1578498192 @default.
- W3108722944 cites W1670890407 @default.
- W3108722944 cites W1888731578 @default.
- W3108722944 cites W1892883644 @default.
- W3108722944 cites W1907833971 @default.
- W3108722944 cites W1964356620 @default.
- W3108722944 cites W1964935932 @default.
- W3108722944 cites W1967512837 @default.
- W3108722944 cites W1971563489 @default.
- W3108722944 cites W1972507748 @default.
- W3108722944 cites W1973089587 @default.
- W3108722944 cites W1974987174 @default.
- W3108722944 cites W1977894565 @default.
- W3108722944 cites W1979383751 @default.
- W3108722944 cites W1979615123 @default.
- W3108722944 cites W1982447134 @default.
- W3108722944 cites W1987892305 @default.
- W3108722944 cites W1989439022 @default.
- W3108722944 cites W1993006648 @default.
- W3108722944 cites W1994423139 @default.
- W3108722944 cites W1998289682 @default.
- W3108722944 cites W1998650056 @default.
- W3108722944 cites W1998901389 @default.
- W3108722944 cites W1998972215 @default.
- W3108722944 cites W2001061424 @default.
- W3108722944 cites W2004754771 @default.
- W3108722944 cites W2006344735 @default.
- W3108722944 cites W2008957190 @default.
- W3108722944 cites W2010199370 @default.
- W3108722944 cites W2012071760 @default.
- W3108722944 cites W2012549032 @default.
- W3108722944 cites W2015181454 @default.
- W3108722944 cites W2016126437 @default.
- W3108722944 cites W2025522134 @default.
- W3108722944 cites W2026733880 @default.
- W3108722944 cites W2027156617 @default.
- W3108722944 cites W2027250161 @default.
- W3108722944 cites W2029378715 @default.
- W3108722944 cites W2030029307 @default.
- W3108722944 cites W2030637965 @default.
- W3108722944 cites W2030914871 @default.
- W3108722944 cites W2031188779 @default.
- W3108722944 cites W2031462648 @default.
- W3108722944 cites W2032727505 @default.
- W3108722944 cites W2032837153 @default.
- W3108722944 cites W2032889348 @default.
- W3108722944 cites W2033087883 @default.
- W3108722944 cites W2035649554 @default.
- W3108722944 cites W2036199882 @default.
- W3108722944 cites W2038774969 @default.
- W3108722944 cites W2040794674 @default.
- W3108722944 cites W2046822015 @default.
- W3108722944 cites W2048609123 @default.
- W3108722944 cites W2049132016 @default.
- W3108722944 cites W2049471883 @default.
- W3108722944 cites W2049592557 @default.
- W3108722944 cites W2052373675 @default.
- W3108722944 cites W2055867153 @default.
- W3108722944 cites W2058096164 @default.
- W3108722944 cites W2059647424 @default.
- W3108722944 cites W2060451182 @default.
- W3108722944 cites W2061089961 @default.
- W3108722944 cites W2061298263 @default.
- W3108722944 cites W2062950240 @default.
- W3108722944 cites W2065272050 @default.
- W3108722944 cites W2068506802 @default.
- W3108722944 cites W2069096538 @default.
- W3108722944 cites W2069977719 @default.
- W3108722944 cites W2070831457 @default.
- W3108722944 cites W2073415775 @default.
- W3108722944 cites W2073511180 @default.
- W3108722944 cites W2074341970 @default.
- W3108722944 cites W2077670436 @default.
- W3108722944 cites W2081244127 @default.
- W3108722944 cites W2084272633 @default.
- W3108722944 cites W2086603807 @default.
- W3108722944 cites W2090063730 @default.
- W3108722944 cites W2091140665 @default.
- W3108722944 cites W2091928488 @default.
- W3108722944 cites W2093191361 @default.
- W3108722944 cites W2096297864 @default.
- W3108722944 cites W2100268116 @default.
- W3108722944 cites W2100454719 @default.
- W3108722944 cites W2110148884 @default.
- W3108722944 cites W2110781930 @default.
- W3108722944 cites W2110947634 @default.
- W3108722944 cites W2113313728 @default.
- W3108722944 cites W2113547540 @default.
- W3108722944 cites W2121249997 @default.