FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108773070> ?p ?o ?g. }

• W3108773070 abstract "Abstract Background/Introduction Patients with cancer-associated venous thromboembolisms (VTEs) have a markedly higher risk of recurrence as well as bleeding, compared to those without, leading to difficulty in achieving a good risk-to-benefit balance with anticoagulation therapy. Thus, the assessment of the risk of recurrence in an individual patient is essential. The modified Ottawa score has been developed to predict the risk of recurrence in patients with cancer-associated VTEs during anticoagulation therapy, however, the validity of the score is still controversial. Purpose We aimed to evaluate the utility and limitations of the modified Ottawa score in the risk stratification of recurrent VTEs in patients with cancer-associated VTEs. Methods The COMMAND VTE Registry is a multicenter retrospective registry enrolling 3027 consecutive patients with acute symptomatic VTEs among 29 Japanese centers between January 2010 and August 2014. The present study population consisted of 614 cancer-associated VTE patients with anticoagulation therapy beyond 10 days after the diagnosis, who were divided into 3 groups; High-risk group with a modified Ottawa score ≥1, Intermediate-risk group with a score = 0, and Low-risk group with a score ≤−1. To evaluate the discriminating power of the modified Ottawa score for recurrence, we described the receiver operating characteristic curve with a C-statistic, and evaluated the positive likelihood ratio as the predictive performance of the score for recurrence in each subgroup. Results The high-risk group accounted for 202 patients (33%), intermediate-risk group for 269 (44%), and low-risk group for 143 (23%). During the first 6 months of anticoagulation therapy, recurrent VTEs occurred in 39 patients. The cumulative incidence of recurrent VTEs substantially increased in the higher risk categories by the modified Ottawa score (High-risk group: 13.6%, Intermediate-risk group: 5.9%, and Low-risk group: 3.0%, Log-rank P=0.02) (Figure 1). The discriminating power of the score was modest with a C-statistic of 0.63 (95% CI 0.55–0.71). The positive likelihood ratios as the predictive performance of the score were 1.71 in the high-risk group, 0.81 in the intermediate-risk group, and 0.42 in the low-risk group. Women and patients with prior VTEs had numerically higher cumulative 6-month incidences of recurrent VTEs compared with those without, while patients with lung cancer, breast cancer, and without metastasis had numerically lower cumulative 6-month incidences of recurrent VTEs. Depending on the presence or absence of each score component, the risks of recurrence seemed to differ in the low-, intermediate-, and high-risk groups. Conclusions The risks of recurrence in patients with cancer-associated VTEs substantially increased in the higher risk categories by using the modified Ottawa score, but the discriminating power of the score for recurrence was modest with a widely variable impact of each score component on recurrence. Figure 1 Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): Research Institute for Production Development, Mitsubishi Tanabe Pharma Corporation" @default.
• W3108773070 created "2020-12-07" @default.
• W3108773070 creator A5016825334 @default.
• W3108773070 creator A5023463037 @default.
• W3108773070 creator A5033861263 @default.
• W3108773070 creator A5043428080 @default.
• W3108773070 creator A5071868544 @default.
• W3108773070 creator A5080185082 @default.
• W3108773070 date "2020-11-01" @default.
• W3108773070 modified "2023-10-16" @default.
• W3108773070 title "Predictive ability of modified Ottawa score for recurrence in patients with cancer-associated venous thromboembolisms: from the COMMAND VTE Registry" @default.
• W3108773070 doi "https://doi.org/10.1093/ehjci/ehaa946.3262" @default.
• W3108773070 hasPublicationYear "2020" @default.
• W3108773070 type Work @default.
• W3108773070 sameAs 3108773070 @default.
• W3108773070 citedByCount "0" @default.
• W3108773070 crossrefType "journal-article" @default.
• W3108773070 hasAuthorship W3108773070A5016825334 @default.
• W3108773070 hasAuthorship W3108773070A5023463037 @default.
• W3108773070 hasAuthorship W3108773070A5033861263 @default.
• W3108773070 hasAuthorship W3108773070A5043428080 @default.
• W3108773070 hasAuthorship W3108773070A5071868544 @default.
• W3108773070 hasAuthorship W3108773070A5080185082 @default.
• W3108773070 hasConcept C11783203 @default.
• W3108773070 hasConcept C121608353 @default.
• W3108773070 hasConcept C12174686 @default.
• W3108773070 hasConcept C126322002 @default.
• W3108773070 hasConcept C141071460 @default.
• W3108773070 hasConcept C187960798 @default.
• W3108773070 hasConcept C2779134260 @default.
• W3108773070 hasConcept C2780868729 @default.
• W3108773070 hasConcept C2991741193 @default.
• W3108773070 hasConcept C38652104 @default.
• W3108773070 hasConcept C41008148 @default.
• W3108773070 hasConcept C58471807 @default.
• W3108773070 hasConcept C71924100 @default.
• W3108773070 hasConcept C95190672 @default.
• W3108773070 hasConceptScore W3108773070C11783203 @default.
• W3108773070 hasConceptScore W3108773070C121608353 @default.
• W3108773070 hasConceptScore W3108773070C12174686 @default.
• W3108773070 hasConceptScore W3108773070C126322002 @default.
• W3108773070 hasConceptScore W3108773070C141071460 @default.
• W3108773070 hasConceptScore W3108773070C187960798 @default.
• W3108773070 hasConceptScore W3108773070C2779134260 @default.
• W3108773070 hasConceptScore W3108773070C2780868729 @default.
• W3108773070 hasConceptScore W3108773070C2991741193 @default.
• W3108773070 hasConceptScore W3108773070C38652104 @default.
• W3108773070 hasConceptScore W3108773070C41008148 @default.
• W3108773070 hasConceptScore W3108773070C58471807 @default.
• W3108773070 hasConceptScore W3108773070C71924100 @default.
• W3108773070 hasConceptScore W3108773070C95190672 @default.
• W3108773070 hasLocation W31087730701 @default.
• W3108773070 hasOpenAccess W3108773070 @default.
• W3108773070 hasPrimaryLocation W31087730701 @default.
• W3108773070 hasRelatedWork W12927781 @default.
• W3108773070 hasRelatedWork W13098407 @default.
• W3108773070 hasRelatedWork W14214595 @default.
• W3108773070 hasRelatedWork W14228319 @default.
• W3108773070 hasRelatedWork W15852517 @default.
• W3108773070 hasRelatedWork W1756981 @default.
• W3108773070 hasRelatedWork W2011212 @default.
• W3108773070 hasRelatedWork W2422317 @default.
• W3108773070 hasRelatedWork W7623919 @default.
• W3108773070 hasRelatedWork W8613177 @default.
• W3108773070 isParatext "false" @default.
• W3108773070 isRetracted "false" @default.
• W3108773070 magId "3108773070" @default.
• W3108773070 workType "article" @default.