FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108804312> ?p ?o ?g. }

• W3108804312 endingPage "617" @default.
• W3108804312 startingPage "612" @default.
• W3108804312 abstract "Contralateral prophylactic mastectomy (CPM) has been reported to reduce risk of contralateral breast cancer (CBC) by at least 90%. In addition, BRCA carriers present higher risk of ipsilateral recurrence and a second primary tumor. The aim is to evaluate risk of CBC and recurrence and to analyze predictive factors in BRCA1/2 mutation carriers and non-carriers at high-risk of hereditary breast cancer patients. Retrospective observational study. 46 patients underwent bilateral mastectomy during 2004–2018. Cohort comprised of 9 patients BRCA1, 12 BRCA2 and 25 at high-risk without mutation. Median follow-up was 79 months. 16 patients recently diagnosed and 30 previously treated for breast cancer who underwent CPM a second time (because of later detection of BRCA mutation in 10 cases). The external lateral incision was the most frequent surgical technique. In all patients, immediate reconstruction was performed. In CPM pieces, 4 in situ carcinoma, 3 invasive and 1 atypical hyperplasia were found. The incidence of occult contralateral cancer was 15.2%. Recurrence was observed in 5 patients a mean of 21.2 months after surgery. DFSD was 83.74 months and OS 84.33 months. Regression models identified BRCA1/2 mutation and high risk without mutation as significant occult tumor predictive factors while tumor size ≥ 2 cm was predictive of recurrence. In our series we found a 10.8% recurrence despite CPM and 7 patients (15.2%) would have developed a CBC in subsequent years. La mastectomía contralateral profiláctica (CPM) reduce el riesgo de cáncer contralateral en al menos un 90%. Además, las portadoras de mutación BRCA tienen mayor riesgo de recurrencia ipsilateral y de un segundo tumor primario. El objetivo es evaluar el riesgo de cáncer contralateral y la recurrencia, y analizar factores predictivos en pacientes con cáncer de mama y mutaciones BRCA1/2 y no portadoras con alto riesgo de cáncer hereditario. Análisis observacional retrospectivo de 46 pacientes sometidas a mastectomía bilateral durante 2004–2018. Nueve pacientes BRCA1, 12 BRCA2 y 25 con alto riesgo sin mutación. Dieciséis pacientes con diagnóstico de novo y 30 tratadas previamente por cáncer de mama a las que realizamos CPM de manera diferida (en 10 de ellas por detección de mutación en BRCA a posteriori ); mediana de seguimiento 79 meses. La técnica quirúrgica más usada fue la incisión lateral externa. En todas las pacientes se realizó reconstrucción inmediata. En las piezas de CPM se encontraron 4 tumores in situ , 3 invasivos y una hiperplasia atípica. La incidencia de cáncer contralateral oculto fue del 15,2%. Cinco pacientes presentaron recidiva 21,2 meses de media tras la intervención; SLE 83,74 meses y SG 84,33 meses. Los modelos de regresión identificaron mutación BRCA1/2 y alto riesgo sin mutación como factores predictivos significativos para tumor oculto, mientras que el tamaño tumoral ≥ 2 cm fue predictivo de recidiva. En nuestra serie 7 pacientes (15,2%) habrían desarrollado un tumor contralateral en los años posteriores, y un 10,8% presentaron recurrencia a pesar de CPM." @default.
• W3108804312 created "2020-12-07" @default.
• W3108804312 creator A5010102321 @default.
• W3108804312 creator A5013558016 @default.
• W3108804312 creator A5016486618 @default.
• W3108804312 creator A5019580819 @default.
• W3108804312 creator A5078902476 @default.
• W3108804312 date "2020-12-01" @default.
• W3108804312 modified "2023-10-14" @default.
• W3108804312 title "Contralateral breast cancer and tumor recurrence in BRCA1/2 carriers and non-carriers at a high risk of hereditary breast cancer after bilateral mastectomy" @default.
• W3108804312 cites W1936766016 @default.
• W3108804312 cites W1982519786 @default.
• W3108804312 cites W2002561481 @default.
• W3108804312 cites W2009199535 @default.
• W3108804312 cites W2045723104 @default.
• W3108804312 cites W2092786953 @default.
• W3108804312 cites W2103700689 @default.
• W3108804312 cites W2107243201 @default.
• W3108804312 cites W2110137106 @default.
• W3108804312 cites W2116554987 @default.
• W3108804312 cites W2117576401 @default.
• W3108804312 cites W2124189233 @default.
• W3108804312 cites W2136069590 @default.
• W3108804312 cites W2157086121 @default.
• W3108804312 cites W2069208314 @default.
• W3108804312 doi "https://doi.org/10.1016/j.cireng.2020.11.009" @default.
• W3108804312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32505558" @default.
• W3108804312 hasPublicationYear "2020" @default.
• W3108804312 type Work @default.
• W3108804312 sameAs 3108804312 @default.
• W3108804312 citedByCount "0" @default.
• W3108804312 crossrefType "journal-article" @default.
• W3108804312 hasAuthorship W3108804312A5010102321 @default.
• W3108804312 hasAuthorship W3108804312A5013558016 @default.
• W3108804312 hasAuthorship W3108804312A5016486618 @default.
• W3108804312 hasAuthorship W3108804312A5019580819 @default.
• W3108804312 hasAuthorship W3108804312A5078902476 @default.
• W3108804312 hasConcept C120665830 @default.
• W3108804312 hasConcept C121332964 @default.
• W3108804312 hasConcept C121608353 @default.
• W3108804312 hasConcept C126322002 @default.
• W3108804312 hasConcept C141071460 @default.
• W3108804312 hasConcept C142724271 @default.
• W3108804312 hasConcept C143998085 @default.
• W3108804312 hasConcept C167135981 @default.
• W3108804312 hasConcept C204787440 @default.
• W3108804312 hasConcept C2777757722 @default.
• W3108804312 hasConcept C2780194787 @default.
• W3108804312 hasConcept C520017518 @default.
• W3108804312 hasConcept C530470458 @default.
• W3108804312 hasConcept C61511704 @default.
• W3108804312 hasConcept C71924100 @default.
• W3108804312 hasConcept C72563966 @default.
• W3108804312 hasConceptScore W3108804312C120665830 @default.
• W3108804312 hasConceptScore W3108804312C121332964 @default.
• W3108804312 hasConceptScore W3108804312C121608353 @default.
• W3108804312 hasConceptScore W3108804312C126322002 @default.
• W3108804312 hasConceptScore W3108804312C141071460 @default.
• W3108804312 hasConceptScore W3108804312C142724271 @default.
• W3108804312 hasConceptScore W3108804312C143998085 @default.
• W3108804312 hasConceptScore W3108804312C167135981 @default.
• W3108804312 hasConceptScore W3108804312C204787440 @default.
• W3108804312 hasConceptScore W3108804312C2777757722 @default.
• W3108804312 hasConceptScore W3108804312C2780194787 @default.
• W3108804312 hasConceptScore W3108804312C520017518 @default.
• W3108804312 hasConceptScore W3108804312C530470458 @default.
• W3108804312 hasConceptScore W3108804312C61511704 @default.
• W3108804312 hasConceptScore W3108804312C71924100 @default.
• W3108804312 hasConceptScore W3108804312C72563966 @default.
• W3108804312 hasIssue "10" @default.
• W3108804312 hasLocation W31088043121 @default.
• W3108804312 hasOpenAccess W3108804312 @default.
• W3108804312 hasPrimaryLocation W31088043121 @default.
• W3108804312 hasRelatedWork W1936813410 @default.
• W3108804312 hasRelatedWork W2032628103 @default.
• W3108804312 hasRelatedWork W2073129224 @default.
• W3108804312 hasRelatedWork W2083595553 @default.
• W3108804312 hasRelatedWork W2094523134 @default.
• W3108804312 hasRelatedWork W2890165900 @default.
• W3108804312 hasRelatedWork W2930863593 @default.
• W3108804312 hasRelatedWork W3037426265 @default.
• W3108804312 hasRelatedWork W3041481571 @default.
• W3108804312 hasRelatedWork W3213920473 @default.
• W3108804312 hasVolume "98" @default.
• W3108804312 isParatext "false" @default.
• W3108804312 isRetracted "false" @default.
• W3108804312 magId "3108804312" @default.
• W3108804312 workType "article" @default.