FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108821195> ?p ?o ?g. }

• W3108821195 endingPage "1807" @default.
• W3108821195 startingPage "1798" @default.
• W3108821195 abstract "The retention of a large number of solutes that are normally excreted or metabolized by the kidney is responsible for the symptoms typical in uraemic patients. These molecules are defined as uraemic toxins and can be classified into three groups: small water-soluble molecules, middle molecules and protein-bound toxins. Recently, efforts were put towards developing dialysis membranes that allow the removal of large middle molecules without clinically relevant albumin loss. These membranes are the medium cut-off (MCO) membranes that allow the removal of middle molecules up to ∼50 000 Da.We performed a prospective, open-label, controlled, cross-over pilot study comparing expanded haemodialysis (HDx) (novel MCO membrane Theranova 400) and conventional haemodialysis (HD) in 20 prevalent HD patients. Ten patients used conventional HD high-flux dialyser and 10 patients used HDx for 3 months; later the patients switched and received the other treatment for a further 3 months. We then analysed the pro-calcifying effect of uraemic serum in a model of high phosphate(Pi)-induced calcification in vascular smooth muscle cells (VSMCs).In this study, every patient was the control of himself and, interestingly, we found a tendency of less pro-calcifying potential from HDx-treated patients' serum compared with HD. Studying pathogenetic processes involved in high Pi-induced calcium deposition, we found that uraemic serum of HDx-treated patients induced less VSMC necrosis compared with uraemic serum of HD patients. Nevertheless, no differences were found between the different dialytic treatments in the serum potential to induce apoptosis and to modulate the expression of a panel of genes involved in VSMC simil-osteoblastic differentiation such as bone morphogenetic protein 2, runt-related transcription factor 2, osteocalcin, matrix Gla protein, osteopontin, elastin and collagen I α1. In an effort to characterize the difference in uraemic toxin profile during the two different dialytic treatments, we measured a panel of 10 uraemic toxins and 3 precursors, finding a significant increased removal during HDx of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, tryptophane and some of its metabolites, such as 3-indoxyl sulphate, indole 3-acetic acid and kynurenine.These preliminary data are promising, although larger patients' groups are needed to better understand the effects of HDx on vascular calcification." @default.
• W3108821195 created "2020-12-07" @default.
• W3108821195 creator A5008053180 @default.
• W3108821195 creator A5015378571 @default.
• W3108821195 creator A5020452976 @default.
• W3108821195 creator A5047041215 @default.
• W3108821195 creator A5050308704 @default.
• W3108821195 creator A5064594935 @default.
• W3108821195 creator A5071660720 @default.
• W3108821195 creator A5080805117 @default.
• W3108821195 creator A5090694592 @default.
• W3108821195 date "2020-11-30" @default.
• W3108821195 modified "2023-10-01" @default.
• W3108821195 title "Pro-calcifying analysis of uraemic serum from patients treated with medium cut-off membrane in a prospective, cross-over study" @default.
• W3108821195 cites W1479698819 @default.
• W3108821195 cites W1973895552 @default.
• W3108821195 cites W2008678562 @default.
• W3108821195 cites W2027207994 @default.
• W3108821195 cites W2033739825 @default.
• W3108821195 cites W2064094137 @default.
• W3108821195 cites W2066225603 @default.
• W3108821195 cites W2092330109 @default.
• W3108821195 cites W2098915805 @default.
• W3108821195 cites W2102408771 @default.
• W3108821195 cites W2115959517 @default.
• W3108821195 cites W2116063561 @default.
• W3108821195 cites W2124591820 @default.
• W3108821195 cites W2133126756 @default.
• W3108821195 cites W2158862897 @default.
• W3108821195 cites W2166199725 @default.
• W3108821195 cites W2168987491 @default.
• W3108821195 cites W2563522668 @default.
• W3108821195 cites W2615964728 @default.
• W3108821195 cites W2765675154 @default.
• W3108821195 cites W2778292582 @default.
• W3108821195 cites W2895697460 @default.
• W3108821195 cites W2895719402 @default.
• W3108821195 cites W2914650700 @default.
• W3108821195 cites W2937616467 @default.
• W3108821195 cites W2951150370 @default.
• W3108821195 cites W2979597625 @default.
• W3108821195 cites W2985703988 @default.
• W3108821195 cites W3002639088 @default.
• W3108821195 cites W3021167257 @default.
• W3108821195 doi "https://doi.org/10.1093/ckj/sfaa216" @default.
• W3108821195 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8243281" @default.
• W3108821195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34221387" @default.
• W3108821195 hasPublicationYear "2020" @default.
• W3108821195 type Work @default.
• W3108821195 sameAs 3108821195 @default.
• W3108821195 citedByCount "5" @default.
• W3108821195 countsByYear W31088211952021 @default.
• W3108821195 countsByYear W31088211952022 @default.
• W3108821195 countsByYear W31088211952023 @default.
• W3108821195 crossrefType "journal-article" @default.
• W3108821195 hasAuthorship W3108821195A5008053180 @default.
• W3108821195 hasAuthorship W3108821195A5015378571 @default.
• W3108821195 hasAuthorship W3108821195A5020452976 @default.
• W3108821195 hasAuthorship W3108821195A5047041215 @default.
• W3108821195 hasAuthorship W3108821195A5050308704 @default.
• W3108821195 hasAuthorship W3108821195A5064594935 @default.
• W3108821195 hasAuthorship W3108821195A5071660720 @default.
• W3108821195 hasAuthorship W3108821195A5080805117 @default.
• W3108821195 hasAuthorship W3108821195A5090694592 @default.
• W3108821195 hasBestOaLocation W31088211951 @default.
• W3108821195 hasConcept C126322002 @default.
• W3108821195 hasConcept C126894567 @default.
• W3108821195 hasConcept C134018914 @default.
• W3108821195 hasConcept C185592680 @default.
• W3108821195 hasConcept C188816634 @default.
• W3108821195 hasConcept C2776125364 @default.
• W3108821195 hasConcept C2779978075 @default.
• W3108821195 hasConcept C2780309369 @default.
• W3108821195 hasConcept C41625074 @default.
• W3108821195 hasConcept C519063684 @default.
• W3108821195 hasConcept C55493867 @default.
• W3108821195 hasConcept C71924100 @default.
• W3108821195 hasConceptScore W3108821195C126322002 @default.
• W3108821195 hasConceptScore W3108821195C126894567 @default.
• W3108821195 hasConceptScore W3108821195C134018914 @default.
• W3108821195 hasConceptScore W3108821195C185592680 @default.
• W3108821195 hasConceptScore W3108821195C188816634 @default.
• W3108821195 hasConceptScore W3108821195C2776125364 @default.
• W3108821195 hasConceptScore W3108821195C2779978075 @default.
• W3108821195 hasConceptScore W3108821195C2780309369 @default.
• W3108821195 hasConceptScore W3108821195C41625074 @default.
• W3108821195 hasConceptScore W3108821195C519063684 @default.
• W3108821195 hasConceptScore W3108821195C55493867 @default.
• W3108821195 hasConceptScore W3108821195C71924100 @default.
• W3108821195 hasFunder F4320313475 @default.
• W3108821195 hasIssue "7" @default.
• W3108821195 hasLocation W31088211951 @default.
• W3108821195 hasLocation W31088211952 @default.
• W3108821195 hasLocation W31088211953 @default.
• W3108821195 hasLocation W31088211954 @default.
• W3108821195 hasOpenAccess W3108821195 @default.
• W3108821195 hasPrimaryLocation W31088211951 @default.
• W3108821195 hasRelatedWork W1966504330 @default.

• next