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- W3108839190 abstract "Spaceflight missions can cause immune system dysfunction in astronauts with little understanding of immune outcomes in deep space. This study assessed immune responses in mice following ground-based, simulated deep spaceflight conditions, compared with data from astronauts on International Space Station missions. For ground studies, we simulated microgravity using the hindlimb unloaded mouse model alone or in combination with acute simulated galactic cosmic rays or solar particle events irradiation. Immune profiling results revealed unique immune diversity following each experimental condition, suggesting each stressor results in distinct circulating immune responses, with clear consequences for deep spaceflight. Circulating plasma microRNA sequence analysis revealed involvement in immune system dysregulation. Furthermore, a large astronaut cohort showed elevated inflammation during low-Earth orbit missions, thereby supporting our simulated ground experiments in mice. Herein, circulating immune biomarkers are defined by distinct deep space irradiation types coupled to simulated microgravity and could be targets for future space health initiatives." @default.
- W3108839190 created "2020-12-07" @default.
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- W3108839190 date "2020-12-01" @default.
- W3108839190 modified "2023-10-16" @default.
- W3108839190 title "Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice" @default.
- W3108839190 cites W1547476072 @default.
- W3108839190 cites W1969082595 @default.
- W3108839190 cites W1973317449 @default.
- W3108839190 cites W1973791149 @default.
- W3108839190 cites W1974539949 @default.
- W3108839190 cites W1980725116 @default.
- W3108839190 cites W1984423001 @default.
- W3108839190 cites W1985718591 @default.
- W3108839190 cites W1987364842 @default.
- W3108839190 cites W1988284872 @default.
- W3108839190 cites W2000071577 @default.
- W3108839190 cites W2000725303 @default.
- W3108839190 cites W2000777938 @default.
- W3108839190 cites W2001775594 @default.
- W3108839190 cites W2010798628 @default.
- W3108839190 cites W2023482364 @default.
- W3108839190 cites W2030194393 @default.
- W3108839190 cites W2042878988 @default.
- W3108839190 cites W2044325937 @default.
- W3108839190 cites W2048178760 @default.
- W3108839190 cites W2064101193 @default.
- W3108839190 cites W2068030098 @default.
- W3108839190 cites W2073379526 @default.
- W3108839190 cites W2073616573 @default.
- W3108839190 cites W2074331191 @default.
- W3108839190 cites W2080181628 @default.
- W3108839190 cites W2096632716 @default.
- W3108839190 cites W2105108859 @default.
- W3108839190 cites W2105975924 @default.
- W3108839190 cites W2120399781 @default.
- W3108839190 cites W2122290210 @default.
- W3108839190 cites W2128977851 @default.
- W3108839190 cites W2135972913 @default.
- W3108839190 cites W2139476329 @default.
- W3108839190 cites W2140004478 @default.
- W3108839190 cites W2140405290 @default.
- W3108839190 cites W2148658155 @default.
- W3108839190 cites W2153364645 @default.
- W3108839190 cites W2159397094 @default.
- W3108839190 cites W2160003650 @default.
- W3108839190 cites W2165682628 @default.
- W3108839190 cites W2214074259 @default.
- W3108839190 cites W2223346899 @default.
- W3108839190 cites W2308695447 @default.
- W3108839190 cites W2323047896 @default.
- W3108839190 cites W2343186061 @default.
- W3108839190 cites W2346799309 @default.
- W3108839190 cites W2462334806 @default.
- W3108839190 cites W2527404829 @default.
- W3108839190 cites W2549942646 @default.
- W3108839190 cites W2573002484 @default.
- W3108839190 cites W2575282643 @default.
- W3108839190 cites W2584088501 @default.
- W3108839190 cites W2589757706 @default.
- W3108839190 cites W2594591188 @default.
- W3108839190 cites W2605076090 @default.
- W3108839190 cites W2617082402 @default.
- W3108839190 cites W2680122361 @default.
- W3108839190 cites W2743895040 @default.
- W3108839190 cites W2747004888 @default.
- W3108839190 cites W2751792816 @default.
- W3108839190 cites W2781969341 @default.
- W3108839190 cites W2805170482 @default.
- W3108839190 cites W2808186163 @default.
- W3108839190 cites W2809141554 @default.
- W3108839190 cites W2811212358 @default.
- W3108839190 cites W2884309100 @default.
- W3108839190 cites W2889407480 @default.
- W3108839190 cites W2895563103 @default.
- W3108839190 cites W2895925712 @default.
- W3108839190 cites W2898780408 @default.
- W3108839190 cites W2901526222 @default.
- W3108839190 cites W2903357802 @default.
- W3108839190 cites W2912576842 @default.
- W3108839190 cites W2916745842 @default.
- W3108839190 cites W2917399591 @default.
- W3108839190 cites W2922709611 @default.
- W3108839190 cites W2925330066 @default.
- W3108839190 cites W2939018266 @default.
- W3108839190 cites W2961363174 @default.
- W3108839190 cites W2969810951 @default.
- W3108839190 cites W2991616896 @default.