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- W3108873487 endingPage "9226" @default.
- W3108873487 startingPage "9226" @default.
- W3108873487 abstract "Cancer is the second leading cause of death with tens of millions of people diagnosed with cancer every year around the world. Most radio- and chemotherapies aim to eliminate cancer cells, notably by causing severe damage to the DNA. However, efficient repair of such damage represents a common mechanism of resistance to initially effective cytotoxic agents. Thus, development of new generation anticancer drugs that target DNA repair pathways, and more particularly the base excision repair (BER) pathway that is responsible for removal of damaged bases, is of growing interest. The BER pathway is initiated by a set of enzymes known as DNA glycosylases. Unlike several downstream BER enzymes, DNA glycosylases have so far received little attention and the development of specific inhibitors of these enzymes has been lagging. Yet, dysregulation of DNA glycosylases is also known to play a central role in numerous cancers and at different stages of the disease, and thus inhibiting DNA glycosylases is now considered a valid strategy to eliminate cancer cells. This review provides a detailed overview of the activities of DNA glycosylases in normal and cancer cells, their modes of regulation, and their potential as anticancer drug targets." @default.
- W3108873487 created "2020-12-07" @default.
- W3108873487 creator A5044080143 @default.
- W3108873487 creator A5052866417 @default.
- W3108873487 creator A5070876056 @default.
- W3108873487 creator A5085574932 @default.
- W3108873487 date "2020-12-03" @default.
- W3108873487 modified "2023-10-01" @default.
- W3108873487 title "Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets" @default.
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