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- W3108893134 abstract "Abstract Radioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch’s reaction, high-throughput methods and polymer chemistry. A water-soluble polymer with low-cytotoxicity and an excellent anti-radiation capability has been achieved. In in vivo experiments, this polymer is even better than amifostine, which is the only approved radioprotector for clinical applications, in effectively protecting zebrafish embryos from fatally large doses of ionizing radiation (80 Gy X-ray). A mechanistic study also reveals that the radioprotective ability of this polymer originates from its ability to efficiently prevent DNA damage due to high doses of radiation. This is an initial attempt to explore polymer radioprotectors via a multi-component reaction. It allows exploiting functional polymers and provides the underlying insights to guide the design of radioprotective polymers." @default.
- W3108893134 created "2020-12-07" @default.
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- W3108893134 date "2020-12-04" @default.
- W3108893134 modified "2023-10-16" @default.
- W3108893134 title "High-throughput preparation of radioprotective polymers via Hantzsch’s reaction for in vivo X-ray damage determination" @default.
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- W3108893134 doi "https://doi.org/10.1038/s41467-020-20027-0" @default.
- W3108893134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7718248" @default.
- W3108893134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33277480" @default.
- W3108893134 hasPublicationYear "2020" @default.
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