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- W3108918304 abstract "Objective: We aim to identify the relationship lumbar spinal stenosis (LSS) and genetic HLA system.Materials and Methods: The present study investigates 15 cases out of 41 (7 male, 8 female; average age: 60.27) who were studied for HLA class I ABC genes, as well as totally 41 cases (19 male; 22 female; average age: 60.46) who were studied for HLA class II DR.DQB1 genes among the cases with LSS. DNA extraction, the DNA was amplified with primers specific to HLA-A, B, C, DQ and DR, and studied using the SSP-PCR method. Allele identification was made using the official HLA Nomenclature Committee software.Results: HLA A2 allele in LSS group (%36.7) is statistically significantly higher than control group (%17.2) (p:0.039; p<0.05). The frequency of the B44 allele was statistically significantly higher in the LSS group (20%) than in the control group (5.1%) (p:0.010; p<0.05). Likewise, the frequency of the C6 allele was statistically significantly higher in the LSS group (26.7%) than in the control group (8.6%) (p:0.013; p<0.05). Conclusion: This preliminary study has suggested that LSS is associated with HLA class I genes. HLA A2, HLA B44, and HLA C6 alleles have been determined as predisposing factors for LSS." @default.
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- W3108918304 date "2020-12-30" @default.
- W3108918304 modified "2023-09-25" @default.
- W3108918304 title "Lomber Spinal Stenozun HLA İlişkisi Üzerine Ön Araştırma" @default.
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- W3108918304 doi "https://doi.org/10.26453/otjhs.758530" @default.
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