FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108977673> ?p ?o ?g. }

• W3108977673 endingPage "359" @default.
• W3108977673 startingPage "352" @default.
• W3108977673 abstract "•In patients with >moderate AR, iLVESV not iLVESD was independently related to mortality •Presence of symptoms was more closely related to volumetric than linear dimensions. •The correlation between LV volumes and linear dimensions is only moderate. •Interobserver variability in LV volume estimation is low. •Routine assessment of LV volumes in patients with more than moderate AR is warranted. Background Aortic regurgitation (AR) is a common valvular lesion associated with increased mortality once the left ventricle enlarges significantly or develops systolic dysfunction (ejection fraction < 50%). Valve guidelines recommend aortic valve repair or replacement (AVR) for left ventricular (LV) linear end-systolic dimension ≥ 50 mm or end-diastolic dimension ≥ 65 mm. However, chamber quantification guidelines recommend using LV volume for LV size determination because linear measurements may not accurately reflect LV remodeling. The aim of this study was to evaluate the correlation of LV volumes with linear dimensions, interobserver variability in the estimation of volumes, and the association of volumes with outcomes in patients with AR. Methods A total of 1,100 consecutive patients with chronic moderate to severe and severe AR on echocardiography between 2004 and 2019 were retrospectively analyzed. The modified Simpson disk summation method was used for LV volume estimation. The primary outcome was all-cause mortality; the secondary outcome was mortality censored at AVR. Results Patients’ age was 60 ± 17 years, and 198 were women (18%). Volumes were measured using the biplane method in 939 patients (85%) and the monoplane method in 161 (15%); end-systolic volume was normal in 169 (11%). Correlations between volumes and linear dimensions were 0.5 for end-diastolic volume and 0.6 for end-systolic volume. At median follow-up of 5.4 years (interquartile range, 2.4–10.0 years), 216 patients had died and 539 had undergone AVR. Indexed LV end-systolic volume (iLVESV) and indexed left ventricular end-systolic dimension were both associated with mortality and symptoms, but the association of iLVESV was stronger. iLVESV, age, male gender, Charlson comorbidity index, New York Heart Association functional class III or IV, and time-dependent AVR were independently associated with all-cause mortality. Interobserver variability in the estimation of LV volumes in 200 patients included intraclass coefficients of 0.94 (95% CI, 0.92–0.95) for end-diastolic volume and 0.88 (95% CI, 0.78–0.93) for end-systolic volume. Patients with iLVESV ≥ 45 mL/m2 had lower survival and a higher prevalence of symptoms than those with volumes < 45 mL/m2. Conclusions Echocardiographic LV volume assessment had good reproducibility in patients with moderate to severe and severe AR. The correlation between linear dimensions and volumes was limited. Both iLVESV and indexed left ventricular end-systolic dimension were associated with worse outcomes, but the association of iLVESV was stronger. iLVESV ≥ 45 mL/m2 was associated with worse outcomes. Aortic regurgitation (AR) is a common valvular lesion associated with increased mortality once the left ventricle enlarges significantly or develops systolic dysfunction (ejection fraction < 50%). Valve guidelines recommend aortic valve repair or replacement (AVR) for left ventricular (LV) linear end-systolic dimension ≥ 50 mm or end-diastolic dimension ≥ 65 mm. However, chamber quantification guidelines recommend using LV volume for LV size determination because linear measurements may not accurately reflect LV remodeling. The aim of this study was to evaluate the correlation of LV volumes with linear dimensions, interobserver variability in the estimation of volumes, and the association of volumes with outcomes in patients with AR. A total of 1,100 consecutive patients with chronic moderate to severe and severe AR on echocardiography between 2004 and 2019 were retrospectively analyzed. The modified Simpson disk summation method was used for LV volume estimation. The primary outcome was all-cause mortality; the secondary outcome was mortality censored at AVR. Patients’ age was 60 ± 17 years, and 198 were women (18%). Volumes were measured using the biplane method in 939 patients (85%) and the monoplane method in 161 (15%); end-systolic volume was normal in 169 (11%). Correlations between volumes and linear dimensions were 0.5 for end-diastolic volume and 0.6 for end-systolic volume. At median follow-up of 5.4 years (interquartile range, 2.4–10.0 years), 216 patients had died and 539 had undergone AVR. Indexed LV end-systolic volume (iLVESV) and indexed left ventricular end-systolic dimension were both associated with mortality and symptoms, but the association of iLVESV was stronger. iLVESV, age, male gender, Charlson comorbidity index, New York Heart Association functional class III or IV, and time-dependent AVR were independently associated with all-cause mortality. Interobserver variability in the estimation of LV volumes in 200 patients included intraclass coefficients of 0.94 (95% CI, 0.92–0.95) for end-diastolic volume and 0.88 (95% CI, 0.78–0.93) for end-systolic volume. Patients with iLVESV ≥ 45 mL/m2 had lower survival and a higher prevalence of symptoms than those with volumes < 45 mL/m2. Echocardiographic LV volume assessment had good reproducibility in patients with moderate to severe and severe AR. The correlation between linear dimensions and volumes was limited. Both iLVESV and indexed left ventricular end-systolic dimension were associated with worse outcomes, but the association of iLVESV was stronger. iLVESV ≥ 45 mL/m2 was associated with worse outcomes." @default.
• W3108977673 created "2020-12-07" @default.
• W3108977673 creator A5000044916 @default.
• W3108977673 creator A5017505061 @default.
• W3108977673 creator A5025811215 @default.
• W3108977673 creator A5036643792 @default.
• W3108977673 creator A5038064913 @default.
• W3108977673 creator A5038289246 @default.
• W3108977673 creator A5039045541 @default.
• W3108977673 creator A5066911257 @default.
• W3108977673 creator A5081264767 @default.
• W3108977673 creator A5081475141 @default.
• W3108977673 creator A5085699345 @default.
• W3108977673 date "2021-04-01" @default.
• W3108977673 modified "2023-10-18" @default.
• W3108977673 title "Association of Left Ventricular Volume in Predicting Clinical Outcomes in Patients with Aortic Regurgitation" @default.
• W3108977673 cites W149222749 @default.
• W3108977673 cites W1562820142 @default.
• W3108977673 cites W163142142 @default.
• W3108977673 cites W163250284 @default.
• W3108977673 cites W16620245 @default.
• W3108977673 cites W1947834533 @default.
• W3108977673 cites W1963820442 @default.
• W3108977673 cites W1988124306 @default.
• W3108977673 cites W2007559384 @default.
• W3108977673 cites W2023483730 @default.
• W3108977673 cites W2027887811 @default.
• W3108977673 cites W2029789299 @default.
• W3108977673 cites W2051217768 @default.
• W3108977673 cites W2052780003 @default.
• W3108977673 cites W2061868495 @default.
• W3108977673 cites W2071477700 @default.
• W3108977673 cites W2089385335 @default.
• W3108977673 cites W2094373590 @default.
• W3108977673 cites W2113129736 @default.
• W3108977673 cites W2116917468 @default.
• W3108977673 cites W2122323601 @default.
• W3108977673 cites W2124624517 @default.
• W3108977673 cites W2162738486 @default.
• W3108977673 cites W2197447040 @default.
• W3108977673 cites W2551805780 @default.
• W3108977673 cites W2596797126 @default.
• W3108977673 cites W2768184499 @default.
• W3108977673 cites W2891975710 @default.
• W3108977673 cites W2918349550 @default.
• W3108977673 cites W2919671320 @default.
• W3108977673 cites W2954849095 @default.
• W3108977673 doi "https://doi.org/10.1016/j.echo.2020.11.014" @default.
• W3108977673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33253815" @default.
• W3108977673 hasPublicationYear "2021" @default.
• W3108977673 type Work @default.
• W3108977673 sameAs 3108977673 @default.
• W3108977673 citedByCount "14" @default.
• W3108977673 countsByYear W31089776732021 @default.
• W3108977673 countsByYear W31089776732022 @default.
• W3108977673 countsByYear W31089776732023 @default.
• W3108977673 crossrefType "journal-article" @default.
• W3108977673 hasAuthorship W3108977673A5000044916 @default.
• W3108977673 hasAuthorship W3108977673A5017505061 @default.
• W3108977673 hasAuthorship W3108977673A5025811215 @default.
• W3108977673 hasAuthorship W3108977673A5036643792 @default.
• W3108977673 hasAuthorship W3108977673A5038064913 @default.
• W3108977673 hasAuthorship W3108977673A5038289246 @default.
• W3108977673 hasAuthorship W3108977673A5039045541 @default.
• W3108977673 hasAuthorship W3108977673A5066911257 @default.
• W3108977673 hasAuthorship W3108977673A5081264767 @default.
• W3108977673 hasAuthorship W3108977673A5081475141 @default.
• W3108977673 hasAuthorship W3108977673A5085699345 @default.
• W3108977673 hasConcept C126322002 @default.
• W3108977673 hasConcept C164705383 @default.
• W3108977673 hasConcept C2778198053 @default.
• W3108977673 hasConcept C2778921608 @default.
• W3108977673 hasConcept C2780168065 @default.
• W3108977673 hasConcept C3020038371 @default.
• W3108977673 hasConcept C71924100 @default.
• W3108977673 hasConcept C78085059 @default.
• W3108977673 hasConcept C80461066 @default.
• W3108977673 hasConceptScore W3108977673C126322002 @default.
• W3108977673 hasConceptScore W3108977673C164705383 @default.
• W3108977673 hasConceptScore W3108977673C2778198053 @default.
• W3108977673 hasConceptScore W3108977673C2778921608 @default.
• W3108977673 hasConceptScore W3108977673C2780168065 @default.
• W3108977673 hasConceptScore W3108977673C3020038371 @default.
• W3108977673 hasConceptScore W3108977673C71924100 @default.
• W3108977673 hasConceptScore W3108977673C78085059 @default.
• W3108977673 hasConceptScore W3108977673C80461066 @default.
• W3108977673 hasFunder F4320306143 @default.
• W3108977673 hasIssue "4" @default.
• W3108977673 hasLocation W31089776731 @default.
• W3108977673 hasOpenAccess W3108977673 @default.
• W3108977673 hasPrimaryLocation W31089776731 @default.
• W3108977673 hasRelatedWork W185626139 @default.
• W3108977673 hasRelatedWork W2153868457 @default.
• W3108977673 hasRelatedWork W2316342240 @default.
• W3108977673 hasRelatedWork W2347245660 @default.
• W3108977673 hasRelatedWork W2362265450 @default.
• W3108977673 hasRelatedWork W2375703560 @default.
• W3108977673 hasRelatedWork W2912421895 @default.

• next