Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109073919> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3109073919 endingPage "2813" @default.
- W3109073919 startingPage "2802" @default.
- W3109073919 abstract "Two syntheses of vixotrigine are reported. Route 1, adapted from the medicinal chemistry route, enabled rapid delivery of drug substance for clinical development. Route 2, which was developed to address many of the limitations of Route 1, was used to manufacture pilot quantities of API. Key features of Routes 1 and 2 are the generation of a chiral ketone intermediate from an (S)-pyroglutamic acid derivative and catalytic reduction to introduce the second stereogenic center into the API with high stereoselectivity. Route 2 was developed to address the purification burden attributable to “benzyne-derived” impurities generated in Route 1. The improved process eliminated the possibility of the formation of these impurities, substantially improved the stereoselectivity in the reduction of the alternate cyclic imine intermediate 22, and gave a pilot plant process with significantly enhanced yield and throughput." @default.
- W3109073919 created "2020-12-07" @default.
- W3109073919 creator A5001922046 @default.
- W3109073919 creator A5002404055 @default.
- W3109073919 creator A5043970912 @default.
- W3109073919 creator A5044287717 @default.
- W3109073919 creator A5050855317 @default.
- W3109073919 creator A5051621255 @default.
- W3109073919 creator A5052249595 @default.
- W3109073919 creator A5066211429 @default.
- W3109073919 date "2020-11-24" @default.
- W3109073919 modified "2023-09-25" @default.
- W3109073919 title "Synthesis of Vixotrigine, a Use-Dependent Sodium Channel Blocker. Part 1: Development of Bulk Supply Routes to Enable Proof of Concept" @default.
- W3109073919 cites W1991623029 @default.
- W3109073919 cites W2010580563 @default.
- W3109073919 cites W2035838588 @default.
- W3109073919 cites W2045172500 @default.
- W3109073919 cites W2049960532 @default.
- W3109073919 cites W2060648754 @default.
- W3109073919 cites W2104264344 @default.
- W3109073919 cites W2170714350 @default.
- W3109073919 cites W2172625080 @default.
- W3109073919 cites W2321653311 @default.
- W3109073919 cites W2532194998 @default.
- W3109073919 cites W2589023116 @default.
- W3109073919 cites W2949453580 @default.
- W3109073919 cites W2950689851 @default.
- W3109073919 cites W2951035568 @default.
- W3109073919 cites W3042692851 @default.
- W3109073919 doi "https://doi.org/10.1021/acs.oprd.0c00382" @default.
- W3109073919 hasPublicationYear "2020" @default.
- W3109073919 type Work @default.
- W3109073919 sameAs 3109073919 @default.
- W3109073919 citedByCount "6" @default.
- W3109073919 countsByYear W31090739192020 @default.
- W3109073919 countsByYear W31090739192022 @default.
- W3109073919 crossrefType "journal-article" @default.
- W3109073919 hasAuthorship W3109073919A5001922046 @default.
- W3109073919 hasAuthorship W3109073919A5002404055 @default.
- W3109073919 hasAuthorship W3109073919A5043970912 @default.
- W3109073919 hasAuthorship W3109073919A5044287717 @default.
- W3109073919 hasAuthorship W3109073919A5050855317 @default.
- W3109073919 hasAuthorship W3109073919A5051621255 @default.
- W3109073919 hasAuthorship W3109073919A5052249595 @default.
- W3109073919 hasAuthorship W3109073919A5066211429 @default.
- W3109073919 hasConcept C106159729 @default.
- W3109073919 hasConcept C111771559 @default.
- W3109073919 hasConcept C127413603 @default.
- W3109073919 hasConcept C134121241 @default.
- W3109073919 hasConcept C134195300 @default.
- W3109073919 hasConcept C146686406 @default.
- W3109073919 hasConcept C161790260 @default.
- W3109073919 hasConcept C162324750 @default.
- W3109073919 hasConcept C178790620 @default.
- W3109073919 hasConcept C181647583 @default.
- W3109073919 hasConcept C185592680 @default.
- W3109073919 hasConcept C191897082 @default.
- W3109073919 hasConcept C192562407 @default.
- W3109073919 hasConcept C21880701 @default.
- W3109073919 hasConcept C21951064 @default.
- W3109073919 hasConcept C2777738585 @default.
- W3109073919 hasConcept C2988729646 @default.
- W3109073919 hasConceptScore W3109073919C106159729 @default.
- W3109073919 hasConceptScore W3109073919C111771559 @default.
- W3109073919 hasConceptScore W3109073919C127413603 @default.
- W3109073919 hasConceptScore W3109073919C134121241 @default.
- W3109073919 hasConceptScore W3109073919C134195300 @default.
- W3109073919 hasConceptScore W3109073919C146686406 @default.
- W3109073919 hasConceptScore W3109073919C161790260 @default.
- W3109073919 hasConceptScore W3109073919C162324750 @default.
- W3109073919 hasConceptScore W3109073919C178790620 @default.
- W3109073919 hasConceptScore W3109073919C181647583 @default.
- W3109073919 hasConceptScore W3109073919C185592680 @default.
- W3109073919 hasConceptScore W3109073919C191897082 @default.
- W3109073919 hasConceptScore W3109073919C192562407 @default.
- W3109073919 hasConceptScore W3109073919C21880701 @default.
- W3109073919 hasConceptScore W3109073919C21951064 @default.
- W3109073919 hasConceptScore W3109073919C2777738585 @default.
- W3109073919 hasConceptScore W3109073919C2988729646 @default.
- W3109073919 hasIssue "12" @default.
- W3109073919 hasLocation W31090739191 @default.
- W3109073919 hasOpenAccess W3109073919 @default.
- W3109073919 hasPrimaryLocation W31090739191 @default.
- W3109073919 hasRelatedWork W2006770126 @default.
- W3109073919 hasRelatedWork W2047888616 @default.
- W3109073919 hasRelatedWork W2085525070 @default.
- W3109073919 hasRelatedWork W2158023483 @default.
- W3109073919 hasRelatedWork W2949425261 @default.
- W3109073919 hasRelatedWork W2949836300 @default.
- W3109073919 hasRelatedWork W2953142024 @default.
- W3109073919 hasRelatedWork W4220687897 @default.
- W3109073919 hasRelatedWork W4385897420 @default.
- W3109073919 hasRelatedWork W1978386957 @default.
- W3109073919 hasVolume "24" @default.
- W3109073919 isParatext "false" @default.
- W3109073919 isRetracted "false" @default.
- W3109073919 magId "3109073919" @default.
- W3109073919 workType "article" @default.