Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109108904> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3109108904 endingPage "75" @default.
- W3109108904 startingPage "68" @default.
- W3109108904 abstract "Phyllodes tumors (PTs) are rare epithelial-mesenchymal tumors of the breast with malignant potential. Here, we evaluate the nuclear expression of lymphoid enhancer-binding factor 1 (LEF-1), a transcription factor downstream of Wnt/β-catenin signaling, in fibroepithelial lesions of the breast. Excised fibroepithelial lesions of the breast were retrospectively reviewed, blinded to the original diagnosis, and classified according to World Health Organization (WHO) criteria. A tissue microarray (TMA) was composed with two representative cores from each case, including 24 benign lesions, 11 borderline phyllodes, and 8 malignant PTs. β-Catenin, LEF-1, p120, and E-cadherin immunohistochemistry was performed on the TMA, and staining was quantified. The malignant/borderline PTs showed higher stromal LEF-1 expression than benign tumors (P < 0.001). Stromal cells expressed LEF-1 in 100% (16/16 of core TMA) of malignant phyllodes, compared with 73% (16/22) borderline and 27% (13/48) benign tumors. The average LEF-1 H-score was 24.9, 6.1, and 1.5 for malignant, borderline, and benign tumors, respectively. Nuclear expression of β-catenin in the stromal component was more often seen in malignant than in borderline and benign tumors (44% versus 32% and 23%, respectively). Nine TMA cores of malignant tumors without nuclear β-catenin staining demonstrated LEF-1 expression. Both LEF-1 and nuclear β-catenin showed expression in the majority of borderline/malignant PTs suggesting a biological progression of Wnt/β-catenin pathway activation in the stromal component from benign to malignant tumors. Inhibitors for the Wnt/β-catenin pathway may provide alternative treatment options in the future for malignant or metastatic PTs." @default.
- W3109108904 created "2020-12-07" @default.
- W3109108904 creator A5011363732 @default.
- W3109108904 creator A5032937705 @default.
- W3109108904 creator A5042454182 @default.
- W3109108904 date "2021-02-01" @default.
- W3109108904 modified "2023-09-23" @default.
- W3109108904 title "Expression of lymphoid enhancer-binding factor 1 in breast fibroepithelial lesions" @default.
- W3109108904 cites W1858615891 @default.
- W3109108904 cites W1971352272 @default.
- W3109108904 cites W1989215255 @default.
- W3109108904 cites W1990585089 @default.
- W3109108904 cites W1993562480 @default.
- W3109108904 cites W2009174000 @default.
- W3109108904 cites W2026254108 @default.
- W3109108904 cites W2038208403 @default.
- W3109108904 cites W2044030090 @default.
- W3109108904 cites W2060774203 @default.
- W3109108904 cites W2083981646 @default.
- W3109108904 cites W2085999210 @default.
- W3109108904 cites W2086316954 @default.
- W3109108904 cites W2108124310 @default.
- W3109108904 cites W2113159006 @default.
- W3109108904 cites W2115001053 @default.
- W3109108904 cites W2120563485 @default.
- W3109108904 cites W2122277435 @default.
- W3109108904 cites W2142907255 @default.
- W3109108904 cites W2161271678 @default.
- W3109108904 cites W2222365353 @default.
- W3109108904 cites W2261100060 @default.
- W3109108904 cites W2591740296 @default.
- W3109108904 cites W2754574141 @default.
- W3109108904 cites W2781142190 @default.
- W3109108904 cites W2784011655 @default.
- W3109108904 cites W2800109475 @default.
- W3109108904 cites W2902012250 @default.
- W3109108904 cites W2903099338 @default.
- W3109108904 cites W3037566766 @default.
- W3109108904 doi "https://doi.org/10.1016/j.humpath.2020.11.009" @default.
- W3109108904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33245988" @default.
- W3109108904 hasPublicationYear "2021" @default.
- W3109108904 type Work @default.
- W3109108904 sameAs 3109108904 @default.
- W3109108904 citedByCount "0" @default.
- W3109108904 crossrefType "journal-article" @default.
- W3109108904 hasAuthorship W3109108904A5011363732 @default.
- W3109108904 hasAuthorship W3109108904A5032937705 @default.
- W3109108904 hasAuthorship W3109108904A5042454182 @default.
- W3109108904 hasConcept C121608353 @default.
- W3109108904 hasConcept C126322002 @default.
- W3109108904 hasConcept C137620995 @default.
- W3109108904 hasConcept C142724271 @default.
- W3109108904 hasConcept C154456304 @default.
- W3109108904 hasConcept C16930146 @default.
- W3109108904 hasConcept C193270364 @default.
- W3109108904 hasConcept C204232928 @default.
- W3109108904 hasConcept C2780567641 @default.
- W3109108904 hasConcept C502942594 @default.
- W3109108904 hasConcept C530470458 @default.
- W3109108904 hasConcept C55493867 @default.
- W3109108904 hasConcept C62478195 @default.
- W3109108904 hasConcept C71924100 @default.
- W3109108904 hasConcept C86803240 @default.
- W3109108904 hasConceptScore W3109108904C121608353 @default.
- W3109108904 hasConceptScore W3109108904C126322002 @default.
- W3109108904 hasConceptScore W3109108904C137620995 @default.
- W3109108904 hasConceptScore W3109108904C142724271 @default.
- W3109108904 hasConceptScore W3109108904C154456304 @default.
- W3109108904 hasConceptScore W3109108904C16930146 @default.
- W3109108904 hasConceptScore W3109108904C193270364 @default.
- W3109108904 hasConceptScore W3109108904C204232928 @default.
- W3109108904 hasConceptScore W3109108904C2780567641 @default.
- W3109108904 hasConceptScore W3109108904C502942594 @default.
- W3109108904 hasConceptScore W3109108904C530470458 @default.
- W3109108904 hasConceptScore W3109108904C55493867 @default.
- W3109108904 hasConceptScore W3109108904C62478195 @default.
- W3109108904 hasConceptScore W3109108904C71924100 @default.
- W3109108904 hasConceptScore W3109108904C86803240 @default.
- W3109108904 hasLocation W31091089041 @default.
- W3109108904 hasOpenAccess W3109108904 @default.
- W3109108904 hasPrimaryLocation W31091089041 @default.
- W3109108904 hasRelatedWork W1875314882 @default.
- W3109108904 hasRelatedWork W1987137500 @default.
- W3109108904 hasRelatedWork W1987590349 @default.
- W3109108904 hasRelatedWork W2032234530 @default.
- W3109108904 hasRelatedWork W2037006724 @default.
- W3109108904 hasRelatedWork W2044030090 @default.
- W3109108904 hasRelatedWork W2358565899 @default.
- W3109108904 hasRelatedWork W2397256869 @default.
- W3109108904 hasRelatedWork W2902360315 @default.
- W3109108904 hasRelatedWork W3004800323 @default.
- W3109108904 hasVolume "108" @default.
- W3109108904 isParatext "false" @default.
- W3109108904 isRetracted "false" @default.
- W3109108904 magId "3109108904" @default.
- W3109108904 workType "article" @default.