FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109113531> ?p ?o ?g. }

• W3109113531 endingPage "3279" @default.
• W3109113531 startingPage "3269" @default.
• W3109113531 abstract "Spinal cord stimulation (SCS) is a drug-free treatment for chronic neuropathic pain. Recent SCS technology can record evoked compound action potentials (ECAPs) in the spinal cord during therapy and utilize features of the sensed ECAP to optimize the SCS. The purpose of this work is to characterize the relevant parameters that govern the integrity and morphology of acquired ECAPs, and the implications for pain management clinicians and researchers working with ECAPs.Eight-contact percutaneous SCS leads were implanted into sheep, and a prototype ECAP-sensing system was used to record spinal cord activity across a range of electrode configurations, pulse widths, and stimulus amplitudes. Similar iterative testing was then completed in human subjects who were undergoing trials of commercial SCS systems.Longer pulse width stimulation results in a progressive increase in ECAP latency, a neurophysiologic effect that enables ECAP sensing with longer pulses despite more encroachment by stimulation artifact. ECAPs may manifest a polyphasic morphology-an effect not seen in all subjects studied-with longer pulse width stimulation; these later phases may be used to assess ECAP amplitude when earlier features are effaced by artifact. Triphasic stimulation limits artifact from spinal cord ECAPs at the expense of potentially higher activation thresholds. If applied, alternating polarity stimulation must account for the ECAP latency differences resulting from alternating sites of neural activation.Together, this information can allow the ECAP to be readily distinguished from the stimulation artifact, although movement may continue to be a confounder; caution is inculcated for ECAP signal processing techniques that rely on the stability of the artifact to avoid clinically misleading results. The promise of closed-loop, ECAP-servoed neuromodulation relies on accurate and proper sensing of the ECAP, while clearly elucidating the clinically relevant trade-offs and design choices made to enable these novel features." @default.
• W3109113531 created "2020-12-07" @default.
• W3109113531 creator A5000599518 @default.
• W3109113531 creator A5001917135 @default.
• W3109113531 creator A5089178750 @default.
• W3109113531 date "2020-12-01" @default.
• W3109113531 modified "2023-10-16" @default.
• W3109113531 title "<p>Sensing Evoked Compound Action Potentials from the Spinal Cord: Novel Preclinical and Clinical Considerations for the Pain Management Researcher and Clinician</p>" @default.
• W3109113531 cites W1534332832 @default.
• W3109113531 cites W162246864 @default.
• W3109113531 cites W1990309003 @default.
• W3109113531 cites W2014779151 @default.
• W3109113531 cites W2059300393 @default.
• W3109113531 cites W2060583550 @default.
• W3109113531 cites W2065291000 @default.
• W3109113531 cites W2073570371 @default.
• W3109113531 cites W2108318374 @default.
• W3109113531 cites W2115278591 @default.
• W3109113531 cites W2120490110 @default.
• W3109113531 cites W2131274372 @default.
• W3109113531 cites W2149365458 @default.
• W3109113531 cites W2168520621 @default.
• W3109113531 cites W2336938976 @default.
• W3109113531 cites W267676318 @default.
• W3109113531 cites W2723361935 @default.
• W3109113531 cites W2759113034 @default.
• W3109113531 cites W2893713017 @default.
• W3109113531 cites W2898050113 @default.
• W3109113531 cites W2952747072 @default.
• W3109113531 cites W2952983810 @default.
• W3109113531 cites W2962773625 @default.
• W3109113531 cites W2970092375 @default.
• W3109113531 cites W2994842882 @default.
• W3109113531 cites W3016950108 @default.
• W3109113531 cites W3022053216 @default.
• W3109113531 cites W4296220478 @default.
• W3109113531 doi "https://doi.org/10.2147/jpr.s289098" @default.
• W3109113531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7733896" @default.
• W3109113531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33328760" @default.
• W3109113531 hasPublicationYear "2020" @default.
• W3109113531 type Work @default.
• W3109113531 sameAs 3109113531 @default.
• W3109113531 citedByCount "13" @default.
• W3109113531 countsByYear W31091135312021 @default.
• W3109113531 countsByYear W31091135312022 @default.
• W3109113531 countsByYear W31091135312023 @default.
• W3109113531 crossrefType "journal-article" @default.
• W3109113531 hasAuthorship W3109113531A5000599518 @default.
• W3109113531 hasAuthorship W3109113531A5001917135 @default.
• W3109113531 hasAuthorship W3109113531A5089178750 @default.
• W3109113531 hasBestOaLocation W31091135311 @default.
• W3109113531 hasConcept C136229726 @default.
• W3109113531 hasConcept C15744967 @default.
• W3109113531 hasConcept C169760540 @default.
• W3109113531 hasConcept C185263204 @default.
• W3109113531 hasConcept C24998067 @default.
• W3109113531 hasConcept C2779010991 @default.
• W3109113531 hasConcept C2779918689 @default.
• W3109113531 hasConcept C2780775167 @default.
• W3109113531 hasConcept C2984781990 @default.
• W3109113531 hasConcept C41008148 @default.
• W3109113531 hasConcept C542102704 @default.
• W3109113531 hasConcept C71924100 @default.
• W3109113531 hasConcept C76155785 @default.
• W3109113531 hasConcept C82876162 @default.
• W3109113531 hasConcept C86803240 @default.
• W3109113531 hasConceptScore W3109113531C136229726 @default.
• W3109113531 hasConceptScore W3109113531C15744967 @default.
• W3109113531 hasConceptScore W3109113531C169760540 @default.
• W3109113531 hasConceptScore W3109113531C185263204 @default.
• W3109113531 hasConceptScore W3109113531C24998067 @default.
• W3109113531 hasConceptScore W3109113531C2779010991 @default.
• W3109113531 hasConceptScore W3109113531C2779918689 @default.
• W3109113531 hasConceptScore W3109113531C2780775167 @default.
• W3109113531 hasConceptScore W3109113531C2984781990 @default.
• W3109113531 hasConceptScore W3109113531C41008148 @default.
• W3109113531 hasConceptScore W3109113531C542102704 @default.
• W3109113531 hasConceptScore W3109113531C71924100 @default.
• W3109113531 hasConceptScore W3109113531C76155785 @default.
• W3109113531 hasConceptScore W3109113531C82876162 @default.
• W3109113531 hasConceptScore W3109113531C86803240 @default.
• W3109113531 hasLocation W31091135311 @default.
• W3109113531 hasLocation W31091135312 @default.
• W3109113531 hasLocation W31091135313 @default.
• W3109113531 hasOpenAccess W3109113531 @default.
• W3109113531 hasPrimaryLocation W31091135311 @default.
• W3109113531 hasRelatedWork W2000265984 @default.
• W3109113531 hasRelatedWork W2010991989 @default.
• W3109113531 hasRelatedWork W2285204062 @default.
• W3109113531 hasRelatedWork W2319149251 @default.
• W3109113531 hasRelatedWork W2472183433 @default.
• W3109113531 hasRelatedWork W2621992695 @default.
• W3109113531 hasRelatedWork W2910716342 @default.
• W3109113531 hasRelatedWork W4229457190 @default.
• W3109113531 hasRelatedWork W4236190211 @default.
• W3109113531 hasRelatedWork W4281653414 @default.
• W3109113531 hasVolume "Volume 13" @default.
• W3109113531 isParatext "false" @default.

• next