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- W3109143003 endingPage "576" @default.
- W3109143003 startingPage "567" @default.
- W3109143003 abstract "The ability to sense physical forces is conserved across all organisms. Cells convert mechanical stimuli into electrical or chemical signals via mechanically activated ion channels. In recent years, the identification of new families of mechanosensitive ion channels—such as PIEZO and OSCA/TMEM63 channels—along with surprising insights into well-studied mechanosensitive channels have driven further developments in the mechanotransduction field. Several well-characterized mechanosensory roles such as touch, blood-pressure sensing and hearing are now linked with primary mechanotransducers. Unanticipated roles of mechanical force sensing continue to be uncovered. Furthermore, high-resolution structures representative of nearly every family of mechanically activated channel described so far have underscored their diversity while advancing our understanding of the biophysical mechanisms of pressure sensing. Here we summarize recent discoveries in the physiology and structures of known mechanically activated ion channel families and discuss their implications for understanding the mechanisms of mechanical force sensing." @default.
- W3109143003 created "2020-12-07" @default.
- W3109143003 creator A5066449841 @default.
- W3109143003 creator A5067790213 @default.
- W3109143003 creator A5083836716 @default.
- W3109143003 date "2020-11-25" @default.
- W3109143003 modified "2023-10-17" @default.
- W3109143003 title "Discoveries in structure and physiology of mechanically activated ion channels" @default.
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