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- W3109161811 abstract "Background and objectives: Neural regulation of the cardiovascular system is ensured by the basic principle of the concept of sympathovagal balance. It is not known whether the ANS activity is changed under the conditions of increased efficiency of oxygen utilization in the working muscles by nitrate supplementation. Methods: The subjects (5 M; 5 W; 20-30 y.) will be tested in eight occasions. Subjects will perform a ramp incremental exercise test for determination of the peak VO2 and respiratory threshold. Subjects will receive 6 days of dietary supplementation with beetroot juice and placebo in two separate periods. In the 4th day they pass two 6 minutes degrees of exercise in moderate intensity, each 5th and 6th day one degree of medium and one of high intensity to determine pulmonary VO2 dynamics. Degrees will be separated by 25 minutes of passive recovery. The break between the supplementation periods will last for 12-15 days. The supplementation of beetroot juice or placebo will be used two hours before testing. The ANS activity will be monitored in all investigative days every morning in orthoclinostatic conditions by SA HRV. Before the first exercise bout, body pressure will be measured and venous blood samples will be collected for subsequent determination of plasma nitrite. Results: If the expected results will be achieved (increase on plasma concentration of NO2-, decrease of VO2.kg-1.W-1 in submaximal load, increases in exercise tolerance during high intensity , the ANS activity without the changes), the project will be extended to the patients who are limited by the poor eNOS expression. Conclusions: Beneficial effect of physical rehabilitation after extensive myocardial damage and dysfunction is closely dependent on the bioavailability of NO." @default.
- W3109161811 created "2020-12-07" @default.
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- W3109161811 date "2013-01-01" @default.
- W3109161811 modified "2023-09-27" @default.
- W3109161811 title "INFLUENCE OF DIETARY NITRATE SUPPLEMENTATION ON THE PHYSICAL PERFORMANCE AND THE AUTONOMIC NERVOUS SYSTEM ACTIVITY IN HEALTHY (YOUNG) PEOPLE – PRELIMINARY STUDY" @default.
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