FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109207331> ?p ?o ?g. }

• W3109207331 endingPage "30" @default.
• W3109207331 startingPage "21" @default.
• W3109207331 abstract "Mucinous cystadenoma is one of the most common benign ovarian neoplasms. The immunophenotypes and histogenetic relationships of mucinous cystadenomas with a Müllerian-type epithelium have not been fully explored. We elucidated the direction of differentiation of the mucinous epithelium that constitutes mucinous cystadenomas. Special attention was paid to the existence of gastrointestinal (GI)-type mucinous epithelium, and its association with background Müllerian-type epithelium. Immunohistochemistry was performed in 139 cases of mucinous cystadenoma to evaluate the expression of Claudin-18 (CLDN18), a novel marker of gastric differentiation; CDX2, a marker of intestinal differentiation; and estrogen receptor (ER), a marker of Müllerian differentiation. We found that GI differentiation characterized by CLDN18 and/or CDX2 positivity was observed in mucinous epithelium of most mucinous cystadenomas (129/139 cases, 93%). In a subset of these cases, the tumor was composed of mucinous epithelium exhibiting an intermediate GI and Müllerian phenotype (CLDN18+/CDX2±/ER+). Of note, in 12 cases, a transition from background Müllerian-type epithelium to mucinous epithelium with GI differentiation was identified. A minor subset (6%) of mucinous cystadenomas was considered a pure Müllerian type because the epithelium exhibited a CLDN18-/CDX2-/ER + immunophenotype. In conclusion, mucinous cystadenomas consist of three major subtypes: GI, Müllerian, and intermediate types. Most mucinous cystadenomas are GI-type, and they should be considered a precursor of GI-type mucinous borderline tumors. The existence of intermediate-type mucinous cystadenomas, and areas of transition from Müllerian-type to GI-type epithelium suggest that GI-type mucinous epithelium can arise from Müllerian duct derivatives or surface epithelium exhibiting Müllerian metaplasia in the ovary." @default.
• W3109207331 created "2020-12-07" @default.
• W3109207331 creator A5005708651 @default.
• W3109207331 creator A5008459293 @default.
• W3109207331 creator A5010124046 @default.
• W3109207331 creator A5011690214 @default.
• W3109207331 creator A5022342891 @default.
• W3109207331 creator A5035399792 @default.
• W3109207331 creator A5047392752 @default.
• W3109207331 creator A5075741963 @default.
• W3109207331 creator A5085337453 @default.
• W3109207331 date "2021-03-01" @default.
• W3109207331 modified "2023-10-16" @default.
• W3109207331 title "Comprehensive immunohistochemical analysis of the gastrointestinal and Müllerian phenotypes of 139 ovarian mucinous cystadenomas" @default.
• W3109207331 cites W1826325307 @default.
• W3109207331 cites W1926327739 @default.
• W3109207331 cites W1982982317 @default.
• W3109207331 cites W1991055728 @default.
• W3109207331 cites W1999188964 @default.
• W3109207331 cites W2008322316 @default.
• W3109207331 cites W2012622553 @default.
• W3109207331 cites W2012977923 @default.
• W3109207331 cites W2036672885 @default.
• W3109207331 cites W2037826239 @default.
• W3109207331 cites W2041455809 @default.
• W3109207331 cites W2048677309 @default.
• W3109207331 cites W2051367202 @default.
• W3109207331 cites W2053592928 @default.
• W3109207331 cites W2067416101 @default.
• W3109207331 cites W2094538233 @default.
• W3109207331 cites W2108902851 @default.
• W3109207331 cites W2118228232 @default.
• W3109207331 cites W2122846177 @default.
• W3109207331 cites W2141555443 @default.
• W3109207331 cites W2147810729 @default.
• W3109207331 cites W2293285381 @default.
• W3109207331 cites W2330830420 @default.
• W3109207331 cites W2344824264 @default.
• W3109207331 cites W2548795942 @default.
• W3109207331 cites W2612851374 @default.
• W3109207331 cites W2885069342 @default.
• W3109207331 cites W4236158206 @default.
• W3109207331 cites W4249242318 @default.
• W3109207331 doi "https://doi.org/10.1016/j.humpath.2020.11.011" @default.
• W3109207331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33275953" @default.
• W3109207331 hasPublicationYear "2021" @default.
• W3109207331 type Work @default.
• W3109207331 sameAs 3109207331 @default.
• W3109207331 citedByCount "7" @default.
• W3109207331 countsByYear W31092073312021 @default.
• W3109207331 countsByYear W31092073312022 @default.
• W3109207331 countsByYear W31092073312023 @default.
• W3109207331 crossrefType "journal-article" @default.
• W3109207331 hasAuthorship W3109207331A5005708651 @default.
• W3109207331 hasAuthorship W3109207331A5008459293 @default.
• W3109207331 hasAuthorship W3109207331A5010124046 @default.
• W3109207331 hasAuthorship W3109207331A5011690214 @default.
• W3109207331 hasAuthorship W3109207331A5022342891 @default.
• W3109207331 hasAuthorship W3109207331A5035399792 @default.
• W3109207331 hasAuthorship W3109207331A5047392752 @default.
• W3109207331 hasAuthorship W3109207331A5075741963 @default.
• W3109207331 hasAuthorship W3109207331A5085337453 @default.
• W3109207331 hasConcept C104317684 @default.
• W3109207331 hasConcept C121587040 @default.
• W3109207331 hasConcept C131364181 @default.
• W3109207331 hasConcept C134018914 @default.
• W3109207331 hasConcept C142724271 @default.
• W3109207331 hasConcept C150194340 @default.
• W3109207331 hasConcept C204232928 @default.
• W3109207331 hasConcept C2776313812 @default.
• W3109207331 hasConcept C2777116383 @default.
• W3109207331 hasConcept C2777798143 @default.
• W3109207331 hasConcept C2778324911 @default.
• W3109207331 hasConcept C2778764654 @default.
• W3109207331 hasConcept C529295009 @default.
• W3109207331 hasConcept C55493867 @default.
• W3109207331 hasConcept C71924100 @default.
• W3109207331 hasConcept C86803240 @default.
• W3109207331 hasConceptScore W3109207331C104317684 @default.
• W3109207331 hasConceptScore W3109207331C121587040 @default.
• W3109207331 hasConceptScore W3109207331C131364181 @default.
• W3109207331 hasConceptScore W3109207331C134018914 @default.
• W3109207331 hasConceptScore W3109207331C142724271 @default.
• W3109207331 hasConceptScore W3109207331C150194340 @default.
• W3109207331 hasConceptScore W3109207331C204232928 @default.
• W3109207331 hasConceptScore W3109207331C2776313812 @default.
• W3109207331 hasConceptScore W3109207331C2777116383 @default.
• W3109207331 hasConceptScore W3109207331C2777798143 @default.
• W3109207331 hasConceptScore W3109207331C2778324911 @default.
• W3109207331 hasConceptScore W3109207331C2778764654 @default.
• W3109207331 hasConceptScore W3109207331C529295009 @default.
• W3109207331 hasConceptScore W3109207331C55493867 @default.
• W3109207331 hasConceptScore W3109207331C71924100 @default.
• W3109207331 hasConceptScore W3109207331C86803240 @default.
• W3109207331 hasFunder F4320334764 @default.
• W3109207331 hasLocation W31092073311 @default.
• W3109207331 hasOpenAccess W3109207331 @default.
• W3109207331 hasPrimaryLocation W31092073311 @default.

• next