FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109278604> ?p ?o ?g. }

• W3109278604 endingPage "129053" @default.
• W3109278604 startingPage "129053" @default.
• W3109278604 abstract "The plasticizer di (2-ethylhexyl) phthalate (DEHP) is becoming increasingly abundant throughout the global environment as plastic pollution becomes highly severe, especially in the ocean. The adverse effects of DEHP have garnered increasing concern as they are recognized as endocrine disruptors. However, information on the effects of DEHP in marine organisms remains limited. In this study, acute toxic effects on marine medaka (Oryzias melastigma) following DEHP exposure were investigated. Transcriptome analysis was performed on the livers of medaka exposed to DEHP for 6 and 24 h. Results showed that 1595 genes were affected in all the analyzed specimens, and several genes expressed variably according to sex. Some pathways associated with immunity, metabolism, and endocrine system were significantly enriched, with the complement system appearing to be the most affected immune pathway. Pathway enrichment indicated that, under acute DEHP exposure, the immune response of females tended to be more sensitive than that of males. In addition, ferroptosis occurred in response to DEHP exposure, which resulted in an enrichment of the ferroptosis pathway along with iron overload, an increase in malondialdehyde (MDA) and lipid peroxidation (LPO) content, and a decrease in glutathione (GSH) levels. These results indicate that a form of cell death characterized by iron-dependence occurred following DEHP exposure, but the underlying mechanism requires further analysis. This study implies that DEHP can alter some molecular regulation patterns within a short period and induce cell death through ferroptosis." @default.
• W3109278604 created "2020-12-07" @default.
• W3109278604 creator A5007492792 @default.
• W3109278604 creator A5034391213 @default.
• W3109278604 creator A5036811220 @default.
• W3109278604 creator A5075176483 @default.
• W3109278604 date "2021-02-01" @default.
• W3109278604 modified "2023-10-18" @default.
• W3109278604 title "Acute exposure of di(2-ethylhexyl) phthalate (DEHP) induces immune signal regulation and ferroptosis in oryzias melastigma" @default.
• W3109278604 cites W1929944250 @default.
• W3109278604 cites W1977632523 @default.
• W3109278604 cites W1997183854 @default.
• W3109278604 cites W2010797094 @default.
• W3109278604 cites W2020716716 @default.
• W3109278604 cites W2032307425 @default.
• W3109278604 cites W2043003926 @default.
• W3109278604 cites W2056920219 @default.
• W3109278604 cites W2070744836 @default.
• W3109278604 cites W2077095632 @default.
• W3109278604 cites W2107277218 @default.
• W3109278604 cites W2119947596 @default.
• W3109278604 cites W2123828441 @default.
• W3109278604 cites W2265062179 @default.
• W3109278604 cites W2329387328 @default.
• W3109278604 cites W2384612662 @default.
• W3109278604 cites W2399040568 @default.
• W3109278604 cites W2495703951 @default.
• W3109278604 cites W2518536270 @default.
• W3109278604 cites W2560843419 @default.
• W3109278604 cites W2563416435 @default.
• W3109278604 cites W2734840006 @default.
• W3109278604 cites W2757380495 @default.
• W3109278604 cites W2762087180 @default.
• W3109278604 cites W2768881879 @default.
• W3109278604 cites W2770220579 @default.
• W3109278604 cites W2773070090 @default.
• W3109278604 cites W2785768980 @default.
• W3109278604 cites W2792511415 @default.
• W3109278604 cites W2817900415 @default.
• W3109278604 cites W2883352956 @default.
• W3109278604 cites W2887366257 @default.
• W3109278604 cites W2890567556 @default.
• W3109278604 cites W2894926481 @default.
• W3109278604 cites W2900297598 @default.
• W3109278604 cites W2901913620 @default.
• W3109278604 cites W2911087907 @default.
• W3109278604 cites W2940786643 @default.
• W3109278604 cites W2948317374 @default.
• W3109278604 cites W2965209185 @default.
• W3109278604 cites W2966421376 @default.
• W3109278604 cites W2971758261 @default.
• W3109278604 cites W2991195059 @default.
• W3109278604 cites W3072984397 @default.
• W3109278604 doi "https://doi.org/10.1016/j.chemosphere.2020.129053" @default.
• W3109278604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33272674" @default.
• W3109278604 hasPublicationYear "2021" @default.
• W3109278604 type Work @default.
• W3109278604 sameAs 3109278604 @default.
• W3109278604 citedByCount "27" @default.
• W3109278604 countsByYear W31092786042021 @default.
• W3109278604 countsByYear W31092786042022 @default.
• W3109278604 countsByYear W31092786042023 @default.
• W3109278604 crossrefType "journal-article" @default.
• W3109278604 hasAuthorship W3109278604A5007492792 @default.
• W3109278604 hasAuthorship W3109278604A5034391213 @default.
• W3109278604 hasAuthorship W3109278604A5036811220 @default.
• W3109278604 hasAuthorship W3109278604A5075176483 @default.
• W3109278604 hasConcept C104317684 @default.
• W3109278604 hasConcept C150194340 @default.
• W3109278604 hasConcept C162317418 @default.
• W3109278604 hasConcept C178790620 @default.
• W3109278604 hasConcept C181199279 @default.
• W3109278604 hasConcept C185592680 @default.
• W3109278604 hasConcept C203014093 @default.
• W3109278604 hasConcept C2778004101 @default.
• W3109278604 hasConcept C2778401633 @default.
• W3109278604 hasConcept C2780829032 @default.
• W3109278604 hasConcept C2781005124 @default.
• W3109278604 hasConcept C29730261 @default.
• W3109278604 hasConcept C33070731 @default.
• W3109278604 hasConcept C42407357 @default.
• W3109278604 hasConcept C538909803 @default.
• W3109278604 hasConcept C55493867 @default.
• W3109278604 hasConcept C86803240 @default.
• W3109278604 hasConcept C8891405 @default.
• W3109278604 hasConceptScore W3109278604C104317684 @default.
• W3109278604 hasConceptScore W3109278604C150194340 @default.
• W3109278604 hasConceptScore W3109278604C162317418 @default.
• W3109278604 hasConceptScore W3109278604C178790620 @default.
• W3109278604 hasConceptScore W3109278604C181199279 @default.
• W3109278604 hasConceptScore W3109278604C185592680 @default.
• W3109278604 hasConceptScore W3109278604C203014093 @default.
• W3109278604 hasConceptScore W3109278604C2778004101 @default.
• W3109278604 hasConceptScore W3109278604C2778401633 @default.
• W3109278604 hasConceptScore W3109278604C2780829032 @default.
• W3109278604 hasConceptScore W3109278604C2781005124 @default.
• W3109278604 hasConceptScore W3109278604C29730261 @default.
• W3109278604 hasConceptScore W3109278604C33070731 @default.

• next