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• W3109292330 abstract "Simulations using data from a prospective cohort study.To illustrate how prospective cohort data can be employed in randomized controlled trial (RCT) planning to assess feasibility and operational challenges, using TASCI (Transcutaneous tibial nerve stimulation in patients with Acute Spinal Cord Injury to prevent neurogenic detrusor overactivity: a nationwide randomized, sham-controlled, double-blind clinical trial) as a case study.Spinal cord injury (SCI) rehabilitation centers in Switzerland.TASCI is nested in the multicenter Swiss Spinal Cord Injury Cohort Study (SwiSCI), which prospectively includes patients with acute SCI. In simulations, data from 640 patients, collected by SwiSCI, were used to investigate different scenarios of patient eligibility and study consent, as well as the performance of the randomization list. Descriptive analysis was used to describe the population of interest and the simulation results; multivariable logistic regression analysis was performed to identify predictors of discharge within the TASCI intervention time period.The recruitment target of 114 patients is obtainable within the originally envisioned 3-year time period under the most favorable recruitment scenario examined. The distribution of the primary prognostic factor produced imbalance in the randomization lists and informed further discussion of the cut-off values used in stratification. Influxes of patients resulted in overlapping intervention periods for multiple participants, which guided resource allocation. Early discharge was related to the primary prognostic factor and study center, but is only anticipated in about 8% of participants.Prospective cohort data are a very valuable resource for planning RCTs." @default.
• W3109292330 created "2020-12-07" @default.
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• W3109292330 date "2020-11-24" @default.
• W3109292330 modified "2023-09-27" @default.
• W3109292330 title "Optimizing clinical trial design using prospective cohort study data: a case study in neuro-urology" @default.
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• W3109292330 doi "https://doi.org/10.1038/s41393-020-00588-z" @default.
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