FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109353003> ?p ?o ?g. }

• W3109353003 endingPage "143753" @default.
• W3109353003 startingPage "143753" @default.
• W3109353003 abstract "The aim of this study was to investigate the crosstalk between oxidative stress and autophagy through the ROS/HO-1/NQO1 pathway caused by copper (Cu). Duck renal tubular epithelial cells were treated in Cu sulfate (CuSO4) (0, 100 and 200 μM) for 12 h, and in the combination of CuSO4 (200 μM) and reactive oxygen species (ROS) scavenger (butyl hydroxyanisole, BHA, 100 μM), or HO-1 inhibitor (zinc protoporphyrin, ZnPP, 10 μM) for 12 h. Results revealed that Cu could significantly elevate the levels of intracellular ROS, superoxide dismutase, hydrogen peroxide, malondialdehyde, glutathione, simultaneously reduce catalase and glutathione peroxidase levels, and upregulate HO-1, SOD-1, CAT, NQO1, GCLM mRNA levels and HO-1, SOD-1 protein levels. Additionally, Cu could observably increase the number of autophagosomes, acidic vesicle organelles (AVOs) and LC3 puncta; upregulate mRNA levels of mTOR, Beclin-1, ATG7, ATG5, ATG3, LC3II and protein levels of Beclin-1, LC3II/LC3I, downregulate LC3I mRNA level. Both treatments with BHA and ZnPP could significantly alleviate the changes of antioxidant indexes levels and ROS accumulation, reduce the increase of the number of autophagosomes, AVOs and LC3 puncta, and mitigate the above changed oxidative stress and autophagy related mRNA and protein levels induced by Cu. In summary, our findings indicated that excessive Cu could induce oxidative stress and autophagy by activating the ROS/HO-1/NQO1 pathway, and inhibition of HO-1 might attenuate Cu-induced oxidative stress and autophagy in duck renal tubular epithelial cells." @default.
• W3109353003 created "2020-12-07" @default.
• W3109353003 creator A5008122451 @default.
• W3109353003 creator A5014096233 @default.
• W3109353003 creator A5019129773 @default.
• W3109353003 creator A5021227485 @default.
• W3109353003 creator A5024792434 @default.
• W3109353003 creator A5053141547 @default.
• W3109353003 creator A5057095659 @default.
• W3109353003 creator A5067431012 @default.
• W3109353003 creator A5069469235 @default.
• W3109353003 creator A5081143566 @default.
• W3109353003 date "2021-02-01" @default.
• W3109353003 modified "2023-10-11" @default.
• W3109353003 title "Activation of the ROS/HO-1/NQO1 signaling pathway contributes to the copper-induced oxidative stress and autophagy in duck renal tubular epithelial cells" @default.
• W3109353003 cites W1979762856 @default.
• W3109353003 cites W2042172309 @default.
• W3109353003 cites W2082102400 @default.
• W3109353003 cites W2107604960 @default.
• W3109353003 cites W2126720493 @default.
• W3109353003 cites W2152398648 @default.
• W3109353003 cites W2153362704 @default.
• W3109353003 cites W2192199596 @default.
• W3109353003 cites W2239988923 @default.
• W3109353003 cites W2301505885 @default.
• W3109353003 cites W2318104509 @default.
• W3109353003 cites W2506575686 @default.
• W3109353003 cites W2540170678 @default.
• W3109353003 cites W2563481300 @default.
• W3109353003 cites W2594669844 @default.
• W3109353003 cites W2598555903 @default.
• W3109353003 cites W2623226106 @default.
• W3109353003 cites W2744883277 @default.
• W3109353003 cites W2775328130 @default.
• W3109353003 cites W2794644642 @default.
• W3109353003 cites W2811377868 @default.
• W3109353003 cites W2897299575 @default.
• W3109353003 cites W2907009250 @default.
• W3109353003 cites W2908161517 @default.
• W3109353003 cites W2926584985 @default.
• W3109353003 cites W2934621554 @default.
• W3109353003 cites W2941584720 @default.
• W3109353003 cites W2948095403 @default.
• W3109353003 cites W2949982813 @default.
• W3109353003 cites W2953037856 @default.
• W3109353003 cites W2955888568 @default.
• W3109353003 cites W2965133138 @default.
• W3109353003 cites W2965249906 @default.
• W3109353003 cites W2968066609 @default.
• W3109353003 cites W2968730769 @default.
• W3109353003 cites W2969150001 @default.
• W3109353003 cites W2970578839 @default.
• W3109353003 cites W2970706685 @default.
• W3109353003 cites W2971594637 @default.
• W3109353003 cites W2972499605 @default.
• W3109353003 cites W2980207850 @default.
• W3109353003 cites W2983469954 @default.
• W3109353003 cites W2984287100 @default.
• W3109353003 cites W2986708361 @default.
• W3109353003 cites W2988033841 @default.
• W3109353003 cites W2995440932 @default.
• W3109353003 cites W2998787758 @default.
• W3109353003 cites W3007160636 @default.
• W3109353003 cites W3008348981 @default.
• W3109353003 cites W3013352992 @default.
• W3109353003 cites W3015192771 @default.
• W3109353003 cites W3037140352 @default.
• W3109353003 doi "https://doi.org/10.1016/j.scitotenv.2020.143753" @default.
• W3109353003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33316526" @default.
• W3109353003 hasPublicationYear "2021" @default.
• W3109353003 type Work @default.
• W3109353003 sameAs 3109353003 @default.
• W3109353003 citedByCount "46" @default.
• W3109353003 countsByYear W31093530032021 @default.
• W3109353003 countsByYear W31093530032022 @default.
• W3109353003 countsByYear W31093530032023 @default.
• W3109353003 crossrefType "journal-article" @default.
• W3109353003 hasAuthorship W3109353003A5008122451 @default.
• W3109353003 hasAuthorship W3109353003A5014096233 @default.
• W3109353003 hasAuthorship W3109353003A5019129773 @default.
• W3109353003 hasAuthorship W3109353003A5021227485 @default.
• W3109353003 hasAuthorship W3109353003A5024792434 @default.
• W3109353003 hasAuthorship W3109353003A5053141547 @default.
• W3109353003 hasAuthorship W3109353003A5057095659 @default.
• W3109353003 hasAuthorship W3109353003A5067431012 @default.
• W3109353003 hasAuthorship W3109353003A5069469235 @default.
• W3109353003 hasAuthorship W3109353003A5081143566 @default.
• W3109353003 hasConcept C104317684 @default.
• W3109353003 hasConcept C127561419 @default.
• W3109353003 hasConcept C181199279 @default.
• W3109353003 hasConcept C185592680 @default.
• W3109353003 hasConcept C190283241 @default.
• W3109353003 hasConcept C203522944 @default.
• W3109353003 hasConcept C2775838275 @default.
• W3109353003 hasConcept C2776151105 @default.
• W3109353003 hasConcept C2778979269 @default.
• W3109353003 hasConcept C2781000418 @default.
• W3109353003 hasConcept C48349386 @default.

• next