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• W3109367777 abstract "ABSTRACT Cortical stimulation is emerging as an experimental tool in basic research and a promising therapy for a range of neuropsychiatric conditions. As multielectrode arrays enter clinical practice, the possibility of using spatiotemporal patterns of electrical stimulation to induce desired physiological patterns has become theoretically possible, but in practice can only be implemented by trial-and-error because of a lack of predictive models. Experimental evidence increasingly establishes travelling waves as fundamental to cortical information-processing, but we lack understanding how to control wave properties despite rapidly improving technologies. This study uses a hybrid biophysical-anatomical and neural-computational model to predict and understand how a simple pattern of cortical surface stimulation could induce directional traveling waves via asymmetric activation of inhibitory interneurons. It reveals local circuit mechanisms to control spatiotemporal cortical dynamics and predicts interventions that can be developed to treat a broad range of cognitive disorders." @default.
• W3109367777 created "2020-12-07" @default.
• W3109367777 creator A5004636747 @default.
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• W3109367777 creator A5073804135 @default.
• W3109367777 date "2020-11-29" @default.
• W3109367777 modified "2023-09-27" @default.
• W3109367777 title "Multielectrode Cortical Stimulation Selectively Induces Unidirectional Wave Propagation" @default.
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• W3109367777 doi "https://doi.org/10.1101/2020.11.28.402289" @default.
• W3109367777 hasPublicationYear "2020" @default.
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