Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109369918> ?p ?o ?g. }
- W3109369918 endingPage "107069" @default.
- W3109369918 startingPage "107069" @default.
- W3109369918 abstract "Abstract Current treatment of cholangiocarcinoma (CCA) – a lethal bile duct cancer – is ineffective because the disease is usually diagnosed at late and advanced stage. Thus, a novel therapeutic modality is urgently required. Fourth-generation chimeric antigen receptor (CAR4) T cells was created to target CD133, a well-known cancer stem cell marker, that is highly expressed and associates with cancer progression. The anti-CD133-CAR4 T cells showed high efficacy against CD133-expressing CCA cells. Tumour cell lysis occurred in a dose- and CD133 antigen-dependent manner, and significantly higher, up to 57.59% ± 9.62 at effector to target ratio of 5:1 in a CCA cell line – KKU-213A cells, compared to mock control (p = 0.008). Similarly, significant IFN-γ (p = 0.011) and TNF-α (p = 0.002) upregulation was observed upon tumour treatment. The effectiveness of our anti-CD133-CAR4 T cells will be beneficial not only for CD133-expressing CCA, but also for other CD133-expressing tumours. This study may guide future in vivo study and clinical trials." @default.
- W3109369918 created "2020-12-07" @default.
- W3109369918 creator A5003446927 @default.
- W3109369918 creator A5008629890 @default.
- W3109369918 creator A5009328108 @default.
- W3109369918 creator A5014063904 @default.
- W3109369918 creator A5017605521 @default.
- W3109369918 creator A5021487213 @default.
- W3109369918 creator A5080049867 @default.
- W3109369918 creator A5090303993 @default.
- W3109369918 creator A5090528700 @default.
- W3109369918 date "2020-12-01" @default.
- W3109369918 modified "2023-09-29" @default.
- W3109369918 title "Anti-tumour effect of the fourth-generation chimeric antigen receptor T cells targeting CD133 against cholangiocarcinoma cells" @default.
- W3109369918 cites W1488967791 @default.
- W3109369918 cites W1982449570 @default.
- W3109369918 cites W2012369608 @default.
- W3109369918 cites W2049626897 @default.
- W3109369918 cites W2076946204 @default.
- W3109369918 cites W2078020797 @default.
- W3109369918 cites W2127223872 @default.
- W3109369918 cites W2136892541 @default.
- W3109369918 cites W2293106519 @default.
- W3109369918 cites W2309818502 @default.
- W3109369918 cites W2335984750 @default.
- W3109369918 cites W2396331137 @default.
- W3109369918 cites W2465973558 @default.
- W3109369918 cites W2503553493 @default.
- W3109369918 cites W2513992493 @default.
- W3109369918 cites W2553995108 @default.
- W3109369918 cites W2560087117 @default.
- W3109369918 cites W2565763555 @default.
- W3109369918 cites W2568042564 @default.
- W3109369918 cites W2590361423 @default.
- W3109369918 cites W2596930925 @default.
- W3109369918 cites W2597365729 @default.
- W3109369918 cites W2618582732 @default.
- W3109369918 cites W2726807085 @default.
- W3109369918 cites W2750228412 @default.
- W3109369918 cites W2753242040 @default.
- W3109369918 cites W2766942625 @default.
- W3109369918 cites W2787301955 @default.
- W3109369918 cites W2790491347 @default.
- W3109369918 cites W2790863559 @default.
- W3109369918 cites W2791903162 @default.
- W3109369918 cites W2793614926 @default.
- W3109369918 cites W2801923213 @default.
- W3109369918 cites W2803049227 @default.
- W3109369918 cites W2803391679 @default.
- W3109369918 cites W2805058565 @default.
- W3109369918 cites W2807591162 @default.
- W3109369918 cites W2809145444 @default.
- W3109369918 cites W2883727752 @default.
- W3109369918 cites W2884946612 @default.
- W3109369918 cites W2891825803 @default.
- W3109369918 cites W2900562404 @default.
- W3109369918 cites W2901833439 @default.
- W3109369918 cites W2904266952 @default.
- W3109369918 cites W2904483435 @default.
- W3109369918 cites W2911451382 @default.
- W3109369918 cites W2919253694 @default.
- W3109369918 cites W2919912789 @default.
- W3109369918 cites W2924865280 @default.
- W3109369918 cites W2945932464 @default.
- W3109369918 cites W2950578236 @default.
- W3109369918 cites W2954591108 @default.
- W3109369918 cites W2963298310 @default.
- W3109369918 cites W2968477109 @default.
- W3109369918 cites W2969325999 @default.
- W3109369918 cites W2979336802 @default.
- W3109369918 cites W3012732786 @default.
- W3109369918 cites W3034667778 @default.
- W3109369918 cites W4238000034 @default.
- W3109369918 cites W4251112880 @default.
- W3109369918 cites W65867874 @default.
- W3109369918 doi "https://doi.org/10.1016/j.intimp.2020.107069" @default.
- W3109369918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33242709" @default.
- W3109369918 hasPublicationYear "2020" @default.
- W3109369918 type Work @default.
- W3109369918 sameAs 3109369918 @default.
- W3109369918 citedByCount "22" @default.
- W3109369918 countsByYear W31093699182021 @default.
- W3109369918 countsByYear W31093699182022 @default.
- W3109369918 countsByYear W31093699182023 @default.
- W3109369918 crossrefType "journal-article" @default.
- W3109369918 hasAuthorship W3109369918A5003446927 @default.
- W3109369918 hasAuthorship W3109369918A5008629890 @default.
- W3109369918 hasAuthorship W3109369918A5009328108 @default.
- W3109369918 hasAuthorship W3109369918A5014063904 @default.
- W3109369918 hasAuthorship W3109369918A5017605521 @default.
- W3109369918 hasAuthorship W3109369918A5021487213 @default.
- W3109369918 hasAuthorship W3109369918A5080049867 @default.
- W3109369918 hasAuthorship W3109369918A5090303993 @default.
- W3109369918 hasAuthorship W3109369918A5090528700 @default.
- W3109369918 hasConcept C147483822 @default.
- W3109369918 hasConcept C170493617 @default.
- W3109369918 hasConcept C203014093 @default.
- W3109369918 hasConcept C2777701055 @default.