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• W3109389628 endingPage "e202000965" @default.
• W3109389628 startingPage "e202000965" @default.
• W3109389628 abstract "Hunger drives food-seeking behaviour and controls adaptation of organisms to nutrient availability and energy stores. Lipids constitute an essential source of energy in the cell that can be mobilised during fasting by autophagy. Selective degradation of proteins by autophagy is made possible essentially by the presence of LIR and KFERQ-like motifs. Using in silico screening of Drosophila proteins that contain KFERQ-like motifs, we identified and characterized the adaptor protein Arouser, which functions to regulate fat storage and mobilisation and is essential during periods of food deprivation. We show that hypomorphic arouser mutants are not satiated, are more sensitive to food deprivation, and are more aggressive, suggesting an essential role for Arouser in the coordination of metabolism and food-related behaviour. Our analysis shows that Arouser functions in the fat body through nutrient-related signalling pathways and is degraded by endosomal microautophagy. Arouser degradation occurs during feeding conditions, whereas its stabilisation during non-feeding periods is essential for resistance to starvation and survival. In summary, our data describe a novel role for endosomal microautophagy in energy homeostasis, by the degradation of the signalling regulatory protein Arouser." @default.
• W3109389628 created "2020-12-07" @default.
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• W3109389628 date "2020-12-14" @default.
• W3109389628 modified "2023-10-14" @default.
• W3109389628 title "Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in <i>Drosophila</i>" @default.
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• W3109389628 doi "https://doi.org/10.26508/lsa.202000965" @default.
• W3109389628 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7756965" @default.
• W3109389628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33318080" @default.
• W3109389628 hasPublicationYear "2020" @default.
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