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- W3109431967 endingPage "101865" @default.
- W3109431967 startingPage "101865" @default.
- W3109431967 abstract "Microtubules (MTs) and F-actin (F-act) have long been recognized as key regulators of dendritic morphology. Nevertheless, precisely ascertaining their distinct influences on dendritic trees have been hampered until now by the lack of direct, arbor-wide cytoskeletal quantification. We pair live confocal imaging of fluorescently labeled dendritic arborization (da) neurons in Drosophila larvae with complete multi-signal neural tracing to separately measure MTs and F-act. We demonstrate that dendritic arbor length is highly interrelated with local MT quantity, whereas local F-act enrichment is associated with dendritic branching. Computational simulation of arbor structure solely constrained by experimentally observed subcellular distributions of these cytoskeletal components generated synthetic morphological and molecular patterns statistically equivalent to those of real da neurons, corroborating the efficacy of local MT and F-act in describing dendritic architecture. The analysis and modeling outcomes hold true for the simplest (class I), most complex (class IV), and genetically altered (Formin3 overexpression) da neuron types." @default.
- W3109431967 created "2020-12-07" @default.
- W3109431967 creator A5023097404 @default.
- W3109431967 creator A5033024329 @default.
- W3109431967 creator A5079684009 @default.
- W3109431967 creator A5087672831 @default.
- W3109431967 date "2020-12-01" @default.
- W3109431967 modified "2023-10-17" @default.
- W3109431967 title "Distinct Relations of Microtubules and Actin Filaments with Dendritic Architecture" @default.
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- W3109431967 doi "https://doi.org/10.1016/j.isci.2020.101865" @default.
- W3109431967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7725934" @default.
- W3109431967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33319182" @default.
- W3109431967 hasPublicationYear "2020" @default.
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