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- W3109468120 abstract "Melatonin is of great importance for regulating several eye processes, including pressure homeostasis. Melatonin in combination with agomelatine has been recently reported to reduce intraocular pressure (IOP) with higher efficacy than each compound alone. Here, we used the methylcellulose (MCE) rat model of hypertensive glaucoma, an optic neuropathy characterized by the apoptotic death of retinal ganglion cells (RGCs), to evaluate the hypotensive and neuroprotective efficacy of an eye drop nanomicellar formulation containing melatonin/agomelatine. Eye tissue distribution of melatonin/agomelatine in healthy rats was evaluated by HPLC/MS/MS. In the MCE model, we assessed by tonometry the hypotensive efficacy of melatonin/agomelatine. Neuroprotection was revealed by electroretinography; by levels of inflammatory and apoptotic markers; and by RGC density. The effects of melatonin/agomelatine were compared with those of timolol (a beta blocker with prevalent hypotensive activity) or brimonidine (an alpha 2 adrenergic agonist with potential neuroprotective efficacy), two drugs commonly used to treat glaucoma. Both melatonin and agomelatine penetrate the posterior segment of the eye. In the MCE model, IOP elevation was drastically reduced by melatonin/agomelatine with higher efficacy than that of timolol or brimonidine. Concomitantly, gliosis-related inflammation and the Bax-associated apoptosis were partially prevented, thus leading to RGC survival and recovered retinal dysfunction. We suggest that topical melatoninergic compounds might be beneficial for ocular health." @default.
- W3109468120 created "2020-12-07" @default.
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- W3109468120 date "2020-12-04" @default.
- W3109468120 modified "2023-09-30" @default.
- W3109468120 title "A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma" @default.
- W3109468120 cites W1532218365 @default.
- W3109468120 cites W1552424205 @default.
- W3109468120 cites W169079711 @default.
- W3109468120 cites W182429873 @default.
- W3109468120 cites W1975532588 @default.
- W3109468120 cites W1997513198 @default.
- W3109468120 cites W1999967310 @default.
- W3109468120 cites W2002226160 @default.
- W3109468120 cites W2009412770 @default.
- W3109468120 cites W2016799964 @default.
- W3109468120 cites W2027542654 @default.
- W3109468120 cites W2035866627 @default.
- W3109468120 cites W2037684677 @default.
- W3109468120 cites W2040375605 @default.
- W3109468120 cites W2045338875 @default.
- W3109468120 cites W2049473510 @default.
- W3109468120 cites W2055499548 @default.
- W3109468120 cites W2069138077 @default.
- W3109468120 cites W2070086483 @default.
- W3109468120 cites W2080543701 @default.
- W3109468120 cites W2090302584 @default.
- W3109468120 cites W2110530548 @default.
- W3109468120 cites W2123625063 @default.
- W3109468120 cites W2128362495 @default.
- W3109468120 cites W2129362166 @default.
- W3109468120 cites W2130821242 @default.
- W3109468120 cites W2132946931 @default.
- W3109468120 cites W2149062776 @default.
- W3109468120 cites W2151132444 @default.
- W3109468120 cites W2154053115 @default.
- W3109468120 cites W2157872426 @default.
- W3109468120 cites W2159909449 @default.
- W3109468120 cites W2161376438 @default.
- W3109468120 cites W2161913534 @default.
- W3109468120 cites W2213541252 @default.
- W3109468120 cites W2285256277 @default.
- W3109468120 cites W2306738658 @default.
- W3109468120 cites W2324341744 @default.
- W3109468120 cites W2339850945 @default.
- W3109468120 cites W2370301460 @default.
- W3109468120 cites W2409899358 @default.
- W3109468120 cites W2517336995 @default.
- W3109468120 cites W2560530479 @default.
- W3109468120 cites W2568594876 @default.
- W3109468120 cites W2591803667 @default.
- W3109468120 cites W2611535148 @default.
- W3109468120 cites W2618157249 @default.
- W3109468120 cites W2624489531 @default.
- W3109468120 cites W2765456599 @default.
- W3109468120 cites W2767884041 @default.
- W3109468120 cites W2770034093 @default.
- W3109468120 cites W2771779479 @default.
- W3109468120 cites W2793355134 @default.
- W3109468120 cites W2793407457 @default.
- W3109468120 cites W2809778010 @default.
- W3109468120 cites W2895248798 @default.
- W3109468120 cites W2895374874 @default.
- W3109468120 cites W2899952687 @default.
- W3109468120 cites W2900400403 @default.
- W3109468120 cites W2900782291 @default.
- W3109468120 cites W2905469897 @default.
- W3109468120 cites W2908485546 @default.
- W3109468120 cites W2913596175 @default.
- W3109468120 cites W2916863386 @default.
- W3109468120 cites W2959309135 @default.
- W3109468120 cites W2970381305 @default.
- W3109468120 cites W2976960304 @default.
- W3109468120 cites W2980389078 @default.
- W3109468120 cites W2984343024 @default.
- W3109468120 cites W2988744677 @default.
- W3109468120 cites W2991905021 @default.
- W3109468120 cites W3006107534 @default.
- W3109468120 cites W3007326647 @default.
- W3109468120 cites W3009634179 @default.
- W3109468120 cites W3009949764 @default.
- W3109468120 cites W3018519610 @default.
- W3109468120 cites W3026730573 @default.
- W3109468120 cites W3033671960 @default.
- W3109468120 cites W3048482917 @default.
- W3109468120 cites W33260016 @default.
- W3109468120 cites W71283047 @default.
- W3109468120 doi "https://doi.org/10.3390/ijms21239267" @default.
- W3109468120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7730513" @default.
- W3109468120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33291737" @default.
- W3109468120 hasPublicationYear "2020" @default.
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