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• W3109531871 abstract "Introduction: Antibody-Drug Conjugates (ADCs) have undergone a recent resurgence with 5 product approvals over the last 2 years but for those close to the field, it's been repeated cycles of setbacks and new innovations. A new wave of innovation is in the type of format used to deliver the cytotoxic payloads, with smaller bio-molecules being designed to have more optimal penetration and elimination properties tailored for solid tumors.Areas covered: In this review, the authors cover many of the recently described smaller-format drug conjugates (including formats such as diabodies, Fabs, scFvs, domain antibodies) with an emphasis on the types of conjugation technologies used to attach the chemical linker-payload.Expert opinion: Smaller formats are highly influenced by the structure of the linker-payload, arguably more-so than larger ADCs, so careful consideration is needed where solublising and pharmacokinetic modulation is required. High-quality conjugates are being developed with in vivo tumor efficacy and tolerability properties competitive with ADCs and with a few formats already in clinical development, we expect the pipeline to expand and to reach the market." @default.
• W3109531871 created "2020-12-07" @default.
• W3109531871 creator A5037062506 @default.
• W3109531871 creator A5056862237 @default.
• W3109531871 date "2021-01-11" @default.
• W3109531871 modified "2023-10-06" @default.
• W3109531871 title "Current strategies for the discovery and bioconjugation of smaller, targetable drug conjugates tailored for solid tumor therapy" @default.
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• W3109531871 doi "https://doi.org/10.1080/17460441.2021.1858050" @default.
• W3109531871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33275475" @default.
• W3109531871 hasPublicationYear "2021" @default.
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