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- W3109540451 abstract "Available evidences point to methionine metabolism as a key target to study the molecular adaptive mechanisms underlying differences in longevity. The plasma methionine metabolic profile was determined using a LC-MS/MS platform to systematically define specific phenotypic patterns associated with genotypes of human extreme longevity (centenarians). Our findings demonstrate the presence of a specific plasma profile associated with human longevity characterized by an enhanced transsulfuration pathway and tricarboxylic acid (TCA) cycle intermediates, as well as a reduced content of specific amino acids. Furthermore, our work reveals that centenarians maintain a strongly correlated methionine metabolism, suggesting an improved network integrity, homeostasis and more tightly regulated metabolism. We have discovered a particular methionine signature related to the condition of extreme longevity, allowing the identification of potential mechanisms and biomarkers of healthy aging." @default.
- W3109540451 created "2020-12-07" @default.
- W3109540451 creator A5002931689 @default.
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- W3109540451 creator A5076329737 @default.
- W3109540451 date "2021-01-01" @default.
- W3109540451 modified "2023-10-15" @default.
- W3109540451 title "Methionine transsulfuration pathway is upregulated in long-lived humans" @default.
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