Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109579509> ?p ?o ?g. }
- W3109579509 endingPage "124682" @default.
- W3109579509 startingPage "124682" @default.
- W3109579509 abstract "Hydrogen sulfide (H2S) is an air pollutant, having toxic effects on immune system. Necroptosis has been discussed as a new form of cell death and plays an important role in inflammation. To investigate the mechanism of H2S-induced immune injury, and the role of microRNAs (miRNAs) in this process, based on the results of high-throughput sequencing, we selected the most significantly changed miR-15b-5p for subsequent experiments. We further predicted and determined the targeting relationship between miR-15b-5p and TGFBR3 in HD11 through miRDB, Targetscan and dual-luciferase, and found that miR-15b-5p is highly expressed in H2S-induced necroptosis and inflammation. To understand whether miR-15b-5p/TGFBR3 axis could involve in the process of necroptosis and inflammation, we further revealed that the high expression of miR-15b-5p and the knockdown of TGFBR3 can induce necroptosis. Nec-1 treatment enhanced the survival rate of cells. Notably, H2S exposure induces oxidative stress and activates the TGF-β pathway, which are collectively regulated by the miR-15b-5p/TGFBR3 axis. Our present study provides a new perspective for necroptosis regulated by the miR-15b-5p/TGFBR3 axis and reveals a new form of inflammation regulation in immune diseases." @default.
- W3109579509 created "2020-12-07" @default.
- W3109579509 creator A5001369569 @default.
- W3109579509 creator A5023409516 @default.
- W3109579509 creator A5038854191 @default.
- W3109579509 creator A5053256392 @default.
- W3109579509 creator A5053892310 @default.
- W3109579509 creator A5088940453 @default.
- W3109579509 date "2021-03-01" @default.
- W3109579509 modified "2023-09-23" @default.
- W3109579509 title "Regulation of H2S-induced necroptosis and inflammation in broiler bursa of Fabricius by the miR-15b-5p/TGFBR3 axis and the involvement of oxidative stress in this process" @default.
- W3109579509 cites W1505045336 @default.
- W3109579509 cites W1970451959 @default.
- W3109579509 cites W1990704841 @default.
- W3109579509 cites W1991558095 @default.
- W3109579509 cites W1996249363 @default.
- W3109579509 cites W2023122823 @default.
- W3109579509 cites W2049530394 @default.
- W3109579509 cites W2067875575 @default.
- W3109579509 cites W2085335902 @default.
- W3109579509 cites W2087473058 @default.
- W3109579509 cites W2092795568 @default.
- W3109579509 cites W2101430535 @default.
- W3109579509 cites W2134607740 @default.
- W3109579509 cites W2134895988 @default.
- W3109579509 cites W2144590600 @default.
- W3109579509 cites W2146016283 @default.
- W3109579509 cites W2167628135 @default.
- W3109579509 cites W2167715370 @default.
- W3109579509 cites W2178250841 @default.
- W3109579509 cites W2191498919 @default.
- W3109579509 cites W2260045379 @default.
- W3109579509 cites W2269137221 @default.
- W3109579509 cites W2284771500 @default.
- W3109579509 cites W2344203330 @default.
- W3109579509 cites W2405701538 @default.
- W3109579509 cites W2467178923 @default.
- W3109579509 cites W2618199017 @default.
- W3109579509 cites W2624447401 @default.
- W3109579509 cites W2735731529 @default.
- W3109579509 cites W2752862273 @default.
- W3109579509 cites W2755523766 @default.
- W3109579509 cites W2765115586 @default.
- W3109579509 cites W2771536012 @default.
- W3109579509 cites W2772227821 @default.
- W3109579509 cites W2805246652 @default.
- W3109579509 cites W2807095790 @default.
- W3109579509 cites W2883983923 @default.
- W3109579509 cites W2887758105 @default.
- W3109579509 cites W2891863579 @default.
- W3109579509 cites W2897087452 @default.
- W3109579509 cites W2909759720 @default.
- W3109579509 cites W2913949918 @default.
- W3109579509 cites W2914917364 @default.
- W3109579509 cites W2937808286 @default.
- W3109579509 cites W2946171900 @default.
- W3109579509 cites W2948767830 @default.
- W3109579509 cites W2956337168 @default.
- W3109579509 cites W2963752638 @default.
- W3109579509 cites W2966782990 @default.
- W3109579509 cites W2969762243 @default.
- W3109579509 cites W2971555618 @default.
- W3109579509 cites W2973003320 @default.
- W3109579509 cites W2977402964 @default.
- W3109579509 cites W2982433954 @default.
- W3109579509 cites W2985423931 @default.
- W3109579509 cites W2994826464 @default.
- W3109579509 cites W3000612299 @default.
- W3109579509 cites W3029615794 @default.
- W3109579509 cites W3043852432 @default.
- W3109579509 cites W4237011200 @default.
- W3109579509 cites W4256400463 @default.
- W3109579509 doi "https://doi.org/10.1016/j.jhazmat.2020.124682" @default.
- W3109579509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33307448" @default.
- W3109579509 hasPublicationYear "2021" @default.
- W3109579509 type Work @default.
- W3109579509 sameAs 3109579509 @default.
- W3109579509 citedByCount "48" @default.
- W3109579509 countsByYear W31095795092021 @default.
- W3109579509 countsByYear W31095795092022 @default.
- W3109579509 countsByYear W31095795092023 @default.
- W3109579509 crossrefType "journal-article" @default.
- W3109579509 hasAuthorship W3109579509A5001369569 @default.
- W3109579509 hasAuthorship W3109579509A5023409516 @default.
- W3109579509 hasAuthorship W3109579509A5038854191 @default.
- W3109579509 hasAuthorship W3109579509A5053256392 @default.
- W3109579509 hasAuthorship W3109579509A5053892310 @default.
- W3109579509 hasAuthorship W3109579509A5088940453 @default.
- W3109579509 hasConcept C104317684 @default.
- W3109579509 hasConcept C145059251 @default.
- W3109579509 hasConcept C173396325 @default.
- W3109579509 hasConcept C185592680 @default.
- W3109579509 hasConcept C190283241 @default.
- W3109579509 hasConcept C203014093 @default.
- W3109579509 hasConcept C2776151105 @default.
- W3109579509 hasConcept C2776914184 @default.
- W3109579509 hasConcept C31573885 @default.
- W3109579509 hasConcept C55493867 @default.