FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3109586495> ?p ?o ?g. }

• W3109586495 endingPage "101127" @default.
• W3109586495 startingPage "101127" @default.
• W3109586495 abstract "More than 300 genetic variants have been robustly associated with measures of human adiposity. Highly penetrant mutations causing human obesity do so largely by disrupting satiety pathways in the brain and increasing food intake. Most of the common obesity-predisposing variants are in, or near, genes expressed highly in the brain, but little is known of their function. Exploring the biology of these genes at scale in mammalian systems is challenging. We sought to establish and validate the use of a multicomponent screen for feeding behaviour phenotypes, taking advantage of the tractable model organism Drosophila melanogaster.We validated a screen for feeding behaviour in Drosophila by comparing results after disrupting the expression of centrally expressed genes that influence energy balance in flies to those of 10 control genes. We then used this screen to explore the effects of disrupted expression of genes either a) implicated in energy homeostasis through human genome-wide association studies (GWAS) or b) expressed and nutritionally responsive in specific populations of hypothalamic neurons with a known role in feeding/fasting.Using data from the validation study to classify responses, we studied 53 Drosophila orthologues of genes implicated by human GWAS in body mass index and found that 15 significantly influenced feeding behaviour or energy homeostasis in the Drosophila screen. We then studied 50 Drosophila homologues of 47 murine genes reciprocally nutritionally regulated in POMC and agouti-related peptide neurons. Seven of these 50 genes were found by our screen to influence feeding behaviour in flies.We demonstrated the utility of Drosophila as a tractable model organism in a high-throughput genetic screen for food intake phenotypes. This simple, cost-efficient strategy is ideal for high-throughput interrogation of genes implicated in feeding behaviour and obesity in mammals and will facilitate the process of reaching a functional understanding of obesity pathogenesis." @default.
• W3109586495 created "2020-12-07" @default.
• W3109586495 creator A5013261212 @default.
• W3109586495 creator A5018792950 @default.
• W3109586495 creator A5051620670 @default.
• W3109586495 creator A5064010103 @default.
• W3109586495 creator A5081629872 @default.
• W3109586495 creator A5089747405 @default.
• W3109586495 date "2021-01-01" @default.
• W3109586495 modified "2023-10-16" @default.
• W3109586495 title "A multicomponent screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes" @default.
• W3109586495 cites W1512875938 @default.
• W3109586495 cites W1546792714 @default.
• W3109586495 cites W1584840122 @default.
• W3109586495 cites W1606342288 @default.
• W3109586495 cites W1639930240 @default.
• W3109586495 cites W1965574341 @default.
• W3109586495 cites W1967289063 @default.
• W3109586495 cites W1967661946 @default.
• W3109586495 cites W1969835310 @default.
• W3109586495 cites W1974488383 @default.
• W3109586495 cites W1975700026 @default.
• W3109586495 cites W1976844911 @default.
• W3109586495 cites W1987992613 @default.
• W3109586495 cites W1997921463 @default.
• W3109586495 cites W2000370819 @default.
• W3109586495 cites W2001913879 @default.
• W3109586495 cites W2002176215 @default.
• W3109586495 cites W2012162763 @default.
• W3109586495 cites W2014434238 @default.
• W3109586495 cites W2015918699 @default.
• W3109586495 cites W2016392763 @default.
• W3109586495 cites W2017787601 @default.
• W3109586495 cites W2026037238 @default.
• W3109586495 cites W2026752246 @default.
• W3109586495 cites W2027125425 @default.
• W3109586495 cites W2030254009 @default.
• W3109586495 cites W2030439009 @default.
• W3109586495 cites W2036856264 @default.
• W3109586495 cites W2039153962 @default.
• W3109586495 cites W2041404754 @default.
• W3109586495 cites W2055043387 @default.
• W3109586495 cites W2059171787 @default.
• W3109586495 cites W2067975978 @default.
• W3109586495 cites W2069052477 @default.
• W3109586495 cites W2069072617 @default.
• W3109586495 cites W2079395662 @default.
• W3109586495 cites W2080041937 @default.
• W3109586495 cites W2084650334 @default.
• W3109586495 cites W2087193872 @default.
• W3109586495 cites W2091131524 @default.
• W3109586495 cites W2097620334 @default.
• W3109586495 cites W2098560069 @default.
• W3109586495 cites W2099909245 @default.
• W3109586495 cites W2110643873 @default.
• W3109586495 cites W2111675794 @default.
• W3109586495 cites W2117939265 @default.
• W3109586495 cites W2120132994 @default.
• W3109586495 cites W2121789377 @default.
• W3109586495 cites W2128098876 @default.
• W3109586495 cites W2139359479 @default.
• W3109586495 cites W2144405108 @default.
• W3109586495 cites W2147311167 @default.
• W3109586495 cites W2152306641 @default.
• W3109586495 cites W2152799367 @default.
• W3109586495 cites W2154406648 @default.
• W3109586495 cites W2157765869 @default.
• W3109586495 cites W2166776780 @default.
• W3109586495 cites W2167364244 @default.
• W3109586495 cites W2168132477 @default.
• W3109586495 cites W2243398804 @default.
• W3109586495 cites W2257662942 @default.
• W3109586495 cites W2281301555 @default.
• W3109586495 cites W2319176243 @default.
• W3109586495 cites W2477863367 @default.
• W3109586495 cites W2518901523 @default.
• W3109586495 cites W2538170306 @default.
• W3109586495 cites W2569630460 @default.
• W3109586495 cites W2571803537 @default.
• W3109586495 cites W2584235468 @default.
• W3109586495 cites W2586421092 @default.
• W3109586495 cites W2587731974 @default.
• W3109586495 cites W2671216261 @default.
• W3109586495 cites W2739999456 @default.
• W3109586495 cites W2748443982 @default.
• W3109586495 cites W2755116403 @default.
• W3109586495 cites W2765256236 @default.
• W3109586495 cites W2765268771 @default.
• W3109586495 cites W2771190354 @default.
• W3109586495 cites W2788506294 @default.
• W3109586495 cites W2795547559 @default.
• W3109586495 cites W2936875645 @default.
• W3109586495 cites W2966263312 @default.
• W3109586495 cites W4250359879 @default.
• W3109586495 doi "https://doi.org/10.1016/j.molmet.2020.101127" @default.
• W3109586495 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7753202" @default.
• W3109586495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33242659" @default.
• W3109586495 hasPublicationYear "2021" @default.

• next